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Metrology

Projects/Programs

Keyword

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Detecting Change Points in Surface Temperature Records

Ongoing

DESCRIPTION: For the purpose of exposition, consider the record daily minimums averaged by month for a station near Reno Nevada. There is a clear drop in the level between 1920 and 1940 and a positive drift starting at about 1980. There is also however, considerable variability due to seasonal

Development of Methods for Measurement of Vitamin D and its Metabolites in Foods, Fortified Foods, and Dietary Supplements

Ongoing

Vitamin D exists in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D3 is produced in the body after sun exposure and is also the form used in most fortified foods. Dietary supplements may contain either vitamin D2 or D3. Measurement of vitamin D in foods and dietary

Development of Reference Measurement Procedures and Reference Materials for Creatinine

Ongoing

Kidney function can be evaluated by determining the glomerular filtration rate (GFR), which provides an estimate of how well the kidneys are removing waste and excess fluid from the blood. The GFR is not measured directly. Instead, a measurement of serum creatinine is performed, and this value is

Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum

Ongoing

Steroid hormones and thyroid hormones serve an essential function by regulating gene transcription. Improving the accuracy of clinical assays for hormones will improve diagnoses and result in earlier treatments. Therefore, reference methods for the measurement of steroid and thyroid hormones have

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Ongoing

The clinical measurement of serum cardiac troponin I (cTnI) has become one of the most important tools in the diagnosis of acute myocardial infarction and myocardial damage. Unfortunately, considerable variability in clinical cTnI assay results is observed when comparing assays from different

Photograph of SRM 2669 Arsenic Species in Frozen Human Urine, with vials and desiccant packs, and labeled mylar bag.

Development of SRM 2669 for Accurate Assessment of Arsenic Exposure

Ongoing

Arsenic exposure in the U.S. population is an important part of the NHANES program conducted by CDC because dietary exposure to arsenic can cause serious health effects. A major challenge in the arsenic exposure assessment is that arsenic exists as various species in nature, and the toxicity of

Development of SRM 955c Toxic Elements in Caprine Blood

Completed

Intended Impact Over the last three decades, NIST, with support from the Centers for Disease Control (CDC), and in conjunction with the New York State Department of Health’s (NYSDOH) Wadsworth Center, has produced a number of frozen whole blood certified reference materials containing endogenous

Development of SRMs 2668 and 3668 for Accurate Assessment of Exposure to Toxic Elements and Anions

Completed

Toxic elements in the environment are a threat to public health and safety. Federal and state regulations have been issued to limit and abate the presence of toxic elements in the environment. The levels of toxic elements in the U.S. population are carefully monitored. NHANES is one of the federal

Development of Standards for the World Meteorological Organization, Global Atmosphere Watch Program

Ongoing

Non-methane hydrocarbons (NMHCs) are emitted into the atmosphere by many biogenic and anthropogenic sources that include automobiles and other transportation vehicles, biomass burning, and oceans. In urban environments in particular NMHCs are important because they are precursors and contributors to

Dietary Supplement Laboratory Quality Assurance Program (DSQAP) Consortium

Ongoing

The objective of the DSQAP Consortium is to develop and evaluate measurement methods and standards to support quality and safety for the dietary supplement testing community. Approximately 75% of the U.S. population takes dietary supplements, including vitamins and mineral supplements, representing

Dietary Supplement Laboratory Quality Assurance Program (DSQAP)

Ongoing

Approximately 75% of the U.S. population takes dietary supplements, including vitamins and mineral supplements, representing an annual expenditure of more than $20 billion. Regulations, driven by reported cases of inaccurate labeling, adulteration, contamination (with pesticides, heavy metals, or

Picture of PBD set up for wavelength measurement

Diffraction Metrology and Standards

Ongoing

Diffraction techniques can provide data on a number of sample characteristics. Therefore, the method of certification and the artifact itself are chosen to address a specific measurement issue pertinent to a diffraction experiment. NIST diffraction SRMs may be divided into five groups: Line Position

Documentary Standards: IEC 62755 Standard N42 Data Format

Ongoing

The IEC 62755 standard specifies the XML data format that shall be used for both required and optional data to be made available by radiation measurement instruments. The performance requirements for these types of instruments are described in other IEC standards. The output from these instruments

$Contrast enhancement at the diffraction limit using DUV Fourier ptychography (left) and 3D reconstructed image (right).$

DUV/EUV Nanoscopy for Imaging Nanostructures

Ongoing

Novel optical nanoscopy techniques using deep-ultraviolet (DUV) and extreme-ultraviolet (EUV) laser sources are developed to characterize nanostructures with high dimensional sensitivity and low uncertainty for advancing the semiconductor devices manufacturing process. The illumination beam is

Dynamic EUV Metrology of Nanoscopic Thermal Transport in Active Devices

Ongoing

Heat is greatly impeding progress in microelectronics, which is only getting worse as dimensions are reduced and device architectures move more towards being 3-dimensional. The dynamics and physics of nanoscale thermal transport are unknown and dynamic measurements of active devices at this scale do

Dynamic Mechanical Metrology: Acceleration, Force, and Acoustics

Ongoing

The Dynamic Mechanical Metrology Project develops standards and provides calibrations for SI-traceable acceleration, acoustical and dynamic force metrology. We develop improved reference standards and calibration techniques, sensor-embedded standards, calibration techniques for new technologies, and

Electric Power Metrology and the Smart Grid

Ongoing

Major advancements in electric power generation, transmission, distribution and loads over the last 20 years have led to improvements, reliability, robustness, efficiency and energy security unlike anything from the proceeding 80 years. Combined, this power grid modernization has been called the

Electric Vehicle Supply Equipment (EVSE) Program: Standards, Services, and Training

Ongoing

Weights and measures authorities in each U.S. state and local jurisdiction are responsible for the testing and official inspection of electric vehicle (EV) chargers, specifically the measurement devices that deliver electricity as fuel within commercial EV chargers. These devices are commonly

Massively parallel wafer-level long-term reliability test system featuring 30 fully functioning mini probe stations each supporting 100 probe pins with all the supporting stress/measure electronics integrated (without cables).

Electrical Characterization of Nanoscale Electron Devices

Ongoing

Over the decades, many measurement methods were developed to meet the needs of advancing electron device/circuit/system technology. As technology continue to advance, new needs continue to surface, either due to old measurements are no longer adequate or due to no established method exists. A case

Electric Field Gradient reference prototype

Electrical Scanning Probe Microscopy

Ongoing

Electrical scanning probe microscopes (eSPMs) are a subset of scanning probe microscopes which measure some electrical parameter as well as surface topography. These include techniques such as scanning capacitance microscopy (SCM), scanning spreading resistance microscopy (SSRM), conductive atomic

Electro-acoustic Metrology of Piezoelectric Materials for Wireless Communications

Ongoing

Microwave acoustic filters are widely used to separate and process incoming and outgoing antenna signals on multiple frequency bands for mobile communications, including 5G, WiFi, and Bluetooth data transfer. The U.S. currently dominates manufacturing of these devices, and is home to several major

Electromagnetic Field Strength Metrology

Ongoing

NIST calibrates electrically-small field probes from 10 megahertz – 40 gigahertz. These measurements are done in facilities that are periodically compared against other National Metrology Institutes in conjunction with the Bureau International des Poids et Mesures (BIPM). This assures international

Electron Beam Ion Trap (EBIT) Facility

Ongoing

The NIST EBIT is a table-top device which can produce matter in excess of ten million degrees Kelvin. At these temperatures, even the heaviest atoms shed most of their electrons. The highly charged ions which result are trapped by a configuration of electric and magnetic fields in an ultrahigh

Electronic Biophysical Measurements

Ongoing

We develop measurements that leverage electronic signal transduction using FETs to maximize sensitivity and improve the resolution of biomolecular measurements. The techniques allow direct charge transduction during molecular interactions to quantify fundamental biophysical processes. Critically the

Electronic and Chemical Properties of Systems for Advancing Solid State Quantum-based Devices

Ongoing

Development of new electronic devices for specific functionality and applications typically involves integrating new semiconducting materials. The electronic band structure of a solid is a fundamental property which defines how a material will be used and integrated into device form. Electronic

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