Projects/Programs

Displaying 1 - 25 of 42

Biomanufacturing Initiative

Ongoing

Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The

Certification of Standard Reference Material 2393 for the CAG repeats of Huntington Disease

Ongoing

Huntington disease is a neurodegenerative disease of midlife onset that produces choreic movements and cognitive decline, often accompanied by psychiatric

Certification of a Standard Reference Material for Cytomegalovirus (CMV)

Ongoing

**Update** As of September 1, 2015, SRM 2366a Cytomegalovirus DNA (TowneΔ147 BAC) for DNA Measurements was made available. The new material is a single

Chemical/Biochemical Microsensor Science

Ongoing

The Bioprocess Sensing Group at NIST is investigating a range of fundamental and technological issues related to next-generation chemical and biochemical

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing

As ‘omics moves into industrial and commercial applications, there is a need for quality and process control to ensure safety and efficacy of products and

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

The use of metabolite, lipid, and protein profiles for systems biology, biomedical research, and clinical applications has risen dramatically over recent years

Development of Proteomics-Based Methods for Protein Quantification

Ongoing

NIST is developing methods for the quantification of clinically-relevant protein biomarkers by mass spectrometry. Some methods are intended to establish

Development of Rapid Multiplex PCR Techniques

Ongoing

Forensic DNA typing is currently conducted in approximately eight to ten hours. The process includes DNA extraction, quantitation, multiplex PCR amplification

Computer-generated image of the structure for C-reactive protein

Development of a Reference Measurement Procedure for C-Reactive Protein in Human Serum

Completed

C-reactive protein (CRP) levels in serum or plasma have been used as an indicator of inflammation and infection. Recent evidence also suggests that CRP levels

NIST researcher pipetting solutions into 96-well plate for analysis

Development of Reference Methods and Reference Materials for Protein Biomarkers

Ongoing

Proteins are established markers of health or disease status in clinical samples, and commercial assays have been developed to measure these proteins in a

Development of Reference Methods and Reference Materials for Proteins

Ongoing

A number of proteins show promise as potential markers of health or disease, and commercial assays are being developed for these proteins. For example

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Ongoing

Cardiac troponin I (cTnI) is considered the 'gold standard' for the diagnosis of myocardial infarction and the assessment of cardiac damage. Yet this clinical

Development of SRMs for Serum Proteomics

Ongoing

Serum proteomics, the detection and measurement of as many proteins in a serum sample as possible, could be an important element of personalized medicine

Digital PCR

Ongoing

Digital PCR (dPCR) is a method used to quantify nucleic acids (DNA, RNA, cDNA). At NIST we are using microfluidic and emulsion-based dPCR platforms for

DNA Biometrics

Ongoing

There is ongoing interest in utilizing DNA typing methods for biometric purposes. Forensic DNA typing using STR markers has been performed in the criminal

DNA Mixture Interpretation

Ongoing

Based on data collected over the last year from various forensic labs, (see http://www.cstl.nist.gov/biotech/strbase/mixture.htm) the majority of DNA evidence

DNA Profiling Standard Reference Materials

Ongoing

NIST has produced several PCR-based DNA Profiling Standard Reference Materials (SRMs) for the forensic community. The primary uses of these materials are

Electron Ionization Library Component of the NIST/EPA/NIH Mass Spectral Library and NIST GC Retention Index Database

Ongoing

The National Institute of Standards and Technology (NIST) has developed and maintains evaluated libraries of reference data for the identification of chemicals

Expression of Stable Isotopically Labeled Proteins for Use as Internal Standards for Mass Spectrometric Quantitation of Clinical Protein Biomarkers

Ongoing

Proteins are of significant interest as potential indicators (biomarkers) of health or disease. Clinical methods employed to measure these analytes are often

Biomolecular Measurement Division

Projects/Programs

Biomanufacturing Initiative

Certification of Standard Reference Material 2393 for the CAG repeats of Huntington Disease

Certification of a Standard Reference Material for Cytomegalovirus (CMV)

Chemical/Biochemical Microsensor Science

Consistency Analysis and Uncertainty in ‘omic Data

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Development of Proteomics-Based Methods for Protein Quantification

Development of Rapid Multiplex PCR Techniques

Development of a Reference Measurement Procedure for C-Reactive Protein in Human Serum

Development of Reference Methods and Reference Materials for Protein Biomarkers

Development of Reference Methods and Reference Materials for Proteins

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Development of SRMs for Serum Proteomics

Digital PCR

DNA Biometrics

DNA Mixture Interpretation

DNA Profiling Standard Reference Materials

Electron Ionization Library Component of the NIST/EPA/NIH Mass Spectral Library and NIST GC Retention Index Database

Expression of Stable Isotopically Labeled Proteins for Use as Internal Standards for Mass Spectrometric Quantitation of Clinical Protein Biomarkers

Forensic Applications of Next Generation Sequencing

Glycan Standard Reference Materials

HDX-MS for Biopharmaceutical Analysis

Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program

Metrologies for Protein Structure, Function, and Modeling

Monoclonal Antibody Mass Spectral Libraries

Advanced communications
-Quantum communications
-Wireless (RF)
Bioscience
-Biomanufacturing
-Biomaterials
-Cell biology
-Engineering / synthetic biology
-Genomics
-Glycomics
-Metabolomics
-Microbial measurements
-Proteomics
Buildings and Construction
-Building codes and standards
-Building control systems
-Building damage and repair
-Building economics
-Building materials
-Energy efficiency
-Heating, ventilation and air conditioning equipment
-Indoor air quality
-Structural engineering
-Thermal comfort
Chemistry
-Analytical chemistry
-Chemical engineering and processing
-Chemical thermodynamics and chemical properties
-Molecular characterization
-Theoretical chemistry and modeling
-Thermochemical properties
Electronics
-Electromagnetics
-Flexible electronics
-Magnetoelectronics
-Optoelectronics
-Organic electronics
-Semiconductors
-Sensors
-Superconducting electronics
Energy
-Alternative energy
-Conventional energy
-Electric power / smart grid
-Fuels
Environment
-Air / water / soil quality
-Climate
-Environmental health
-Greenhouse gas measurements
-Marine science
-Sustainability
Fire
-Emergency building evacuation
-Fire detection
-Fire dynamics and science
-Fire fighting
-Fire modeling
-Fire risk reduction
-Materials flammability
-Structural fire resistance
-Wildland urban interface fire
Forensic Science
-Ballistics
-Digital evidence
-DNA and biological evidence
-Drugs and toxicology
-Fingerprints and pattern evidence
-Trace evidence
Health
-Biopharmaceuticals
-Clinical diagnostics
-Dentistry
-Food and nutrition
-Medical imaging
-Precision medicine
-Regenerative medicine and advanced therapy
Information technology
-Artificial intelligence
--AI measurement and evaluation
--Applied AI
--Fundamental AI
--Hardware for AI
--Machine learning
--Trustworthy and responsible AI
-Biometrics
-Cloud computing and virtualization
-Complex systems
-Computational science
-Conformance testing
-Cyber-physical systems
--Smart cities
-Cybersecurity
--Cryptography
--Cybersecurity education and workforce development
--Cybersecurity measurement
--Identity and access management
--Privacy engineering
--Risk management
--Securing emerging technologies
--Trustworthy networks
--Trustworthy platforms
-Data and informatics
--Human language technology
--Information retrieval
--Natural language processing
-Federal information processing standards (FIPS)
-Health IT
-Internet of Things (IoT)
-Interoperability testing
-Mobile
-Networking
--Mobile and wireless networking
--Network management and monitoring
--Network modeling and analysis
--Network security and robustness
--Network test and measurement
--Next generation networks
--Protocol design and standardization
--Software defined and virtual networks
-Privacy
-Software research
--Software testing
-Usability and human factors
--Accessibility
-Video analytics
-Virtual / augmented reality
-Visualization research
-Voting systems
Infrastructure
Manufacturing
-Additive manufacturing
-Factory communications
-Factory operations planning and control
-Interoperability in manufacturing
-Machining
-Manufacturing economics
-Manufacturing systems design and analysis
-Monitoring, diagnostics and prognostics
-Process improvement
-Process measurement and control
-Product data
-Quality assurance
-Robotics in manufacturing
--Agility and adaptability
--Collaborative robots
--Dexterous grasping
--Manipulation
--Mobility and industrial autonomous vehicles
--Navigation / actuation / control
--Sensing and perception
-Supply chain
-Sustainable manufacturing
-Systems engineering
-Systems integration
-Technology commercialization
Materials
-Ceramics
-Composites
-Concrete / cement
-Materials characterization
--Composition and structure
--Mechanical properties
--Thermal properties
-Metals
-Modeling and computational material science
-Polymers
-Superconductors
Mathematics and statistics
-Experiment design
-Image and signal processing
-Modeling and simulation research
-Numerical methods and software
-Statistical analysis
-Uncertainty quantification
Metrology
-Amount of substance
-Dimensional metrology
-Electrical / electromagnetic metrology
-Flow metrology and rheology
-Force metrology
-Humidity metrology
-Ionizing radiation metrology
-Mass metrology
-Metric
-Optical / photometry / laser metrology
-Pressure and vacuum metrology
-Thermometry metrology
-Time and frequency metrology
-Weights and measures
Nanotechnology
-Nanobiotechnology
-Nanochemistry
-Nanoelectronics
-Nanofabrication / manufacturing
--Lithography
--Self-assembly
-Nanofluidics
-Nanomagnetics
-Nanomaterials
-Nanomechanics
-Nanometrology
-Nanophotonics
-Nanophysics
-Nanoplasmonics
Neutron research
Performance excellence
-Assessment tools and services
-Baldrige award
-Baldrige examiners
-Baldrige Framework and Criteria
-Best practices
-Leadership development
Physics
-Atomic / molecular / quantum
-Biological physics
-Condensed matter
-Electron physics
-Magnetics
-Nuclear physics
-Optical physics and communications
-Quantum information science
-Radiation
-Spectroscopy
-Thermodynamics
-Time and frequency
Public safety
-Chemical / Biological / Radiological / Nuclear / Explosives (CBRNE)
-First responder preparedness
-Law enforcement
-Public safety communications research
-Response robots
Resilience
-Community resilience
-Disaster and failure studies
-Earthquake risk reduction
-Resilience economics
-Resilient materials
-Windstorm impact reduction
Standards
-Accreditation
-Calibration services
-Conformity assessment
-Documentary standards
-Frameworks
-Reference data
-Reference instruments
-Reference materials
-Standards education
Transportation
-Aerospace
-Automotive