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Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The
Huntington disease is a neurodegenerative disease of midlife onset that produces choreic movements and cognitive decline, often accompanied by psychiatric
**Update**As of September 1, 2015 SRM 2366a Cytomegalovirus DNA (TowneΔ147 BAC) for DNA Measurements was made available. The new material is a single component
The Bioprocess Sensing Group at NIST is investigating a range of fundamental and technological issues related to next-generation chemical and biochemical
The use of metabolite, lipid, and protein profiles for systems biology, biomedical research, and clinical applications has risen dramatically over recent years
NIST is developing methods for the quantification of clinically-relevant protein biomarkers by mass spectrometry. Some methods are intended to establish
Forensic DNA typing is currently conducted in approximately eight to ten hours. The process includes DNA extraction, quantitation, multiplex PCR amplification
C-reactive protein (CRP) levels in serum or plasma have been used as an indicator of inflammation and infection. Recent evidence also suggests that CRP levels
Cardiac troponin I (cTnI) is considered the 'gold standard' for the diagnosis of myocardial infarction and the assessment of cardiac damage. Yet this clinical
Serum proteomics, the detection and measurement of as many proteins in a serum sample as possible, could be an important element of personalized medicine
Digital PCR (dPCR) is a method used to quantify nucleic acids (DNA, RNA, cDNA). At NIST we are using microfluidic and emulsion-based dPCR platforms for
There is ongoing interest in utilizing DNA typing methods for biometric purposes. Forensic DNA typing using STR markers has been performed in the criminal
NIST has produced several PCR-based DNA Profiling Standard Reference Materials (SRMs) for the forensic community. The primary uses of these materials are
The National Institute of Standards and Technology (NIST) has developed and maintains an Electron Ionization (EI) Library as part of the NIST/EPA/NIH Mass
Proteins are of significant interest as potential indicators (biomarkers) of health or disease. Clinical methods employed to measure these analytes are often
Currently, forensic DNA profiles consist of size measurements which are interpreted as the number of repeat units at STR (short tandem repeat) markers. Due to
This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins
The NIST Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program has been created to demonstrate and improve the comparability of
NIST researchers in the Macromolecular Structure and Function Group are involved in a joint research program with scientists from the University of Maryland
The National Institute of Standards and Technology is developing a mass spectral library of all identifiable components derived from the digestion of monoclonal
Nanocalorimetry using micromachined devices has the capability to provide quantitative data to support the development of advanced metal silicide metallizations
The NIST Food Protein Allergen Program is focused on providing reference materials and methods to improve the connection between the measured protein food