Projects/Programs

Displaying 1 - 25 of 38

Biomanufacturing Initiative

Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The

Certification of Standard Reference Material 2393 for the CAG repeats of Huntington Disease

Huntington disease is a neurodegenerative disease of midlife onset that produces choreic movements and cognitive decline, often accompanied by psychiatric

Certification of a Standard Reference Material for Cytomegalovirus (CMV)

**Update**As of September 1, 2015 SRM 2366a Cytomegalovirus DNA (TowneΔ147 BAC) for DNA Measurements was made available. The new material is a single component

Chemical/Biochemical Microsensor Science

The Bioprocess Sensing Group at NIST is investigating a range of fundamental and technological issues related to next-generation chemical and biochemical

Consistency Analysis and Uncertainty in ‘omic Data

As ‘omics moves into industrial and commercial applications, there is a need for quality and process control to ensure safety and efficacy of products and

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

The use of metabolite, lipid, and protein profiles for systems biology, biomedical research, and clinical applications has risen dramatically over recent years

Development of Proteomics-Based Methods for Protein Quantification

NIST is developing methods for the quantification of clinically-relevant protein biomarkers by mass spectrometry. Some methods are intended to establish

Development of Rapid Multiplex PCR Techniques

Forensic DNA typing is currently conducted in approximately eight to ten hours. The process includes DNA extraction, quantitation, multiplex PCR amplification

Computer-generated image of the structure for C-reactive protein

Development of a Reference Measurement Procedure for C-Reactive Protein in Human Serum

C-reactive protein (CRP) levels in serum or plasma have been used as an indicator of inflammation and infection. Recent evidence also suggests that CRP levels

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Cardiac troponin I (cTnI) is considered the 'gold standard' for the diagnosis of myocardial infarction and the assessment of cardiac damage. Yet this clinical

NIST researcher pipetting solutions into 96-well plate for analysis

Development of Reference Methods and Reference Materials for Protein Biomarkers

Proteins are established markers of health or disease status in clinical samples, and commercial assays have been developed to measure these proteins in a

Development of Reference Methods and Reference Materials for Proteins

A number of proteins show promise as potential markers of health or disease, and commercial assays are being developed for these proteins. For example

Development of SRMs for Serum Proteomics

Serum proteomics, the detection and measurement of as many proteins in a serum sample as possible, could be an important element of personalized medicine

Digital PCR

Digital PCR (dPCR) is a method used to quantify nucleic acids (DNA, RNA, cDNA). At NIST we are using microfluidic and emulsion-based dPCR platforms for

DNA Biometrics

There is ongoing interest in utilizing DNA typing methods for biometric purposes. Forensic DNA typing using STR markers has been performed in the criminal

DNA Mixture Interpretation

Based on data collected over the last year from various forensic labs, (see http://www.cstl.nist.gov/biotech/strbase/mixture.htm) the majority of DNA evidence

DNA Profiling Standard Reference Materials

NIST has produced several PCR-based DNA Profiling Standard Reference Materials (SRMs) for the forensic community. The primary uses of these materials are

Electron Ionization Library Component of the NIST/EPA/NIH Mass Spectral Library and NIST GC Retention Index Database

The National Institute of Standards and Technology (NIST) has developed and maintains evaluated libraries of reference data for the identification of chemicals

Expression of Stable Isotopically Labeled Proteins for Use as Internal Standards for Mass Spectrometric Quantitation of Clinical Protein Biomarkers

Proteins are of significant interest as potential indicators (biomarkers) of health or disease. Clinical methods employed to measure these analytes are often

Biomolecular Measurement Division