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Summary
MixMaSTR: A Software Package for Designing and Interpreting Forensic DNA Validation Studies.
Description
A screen shot of the landing screen for MixMaSTR software
We are in the process of developing a standalone help for practitioners in an easy-to-use application with a well-designed graphical user interface that will:
- Generating all possible mixture genotype combinations from their provided ground truth single-source profiles and selected NoCs
- Computing various metrics of interest for each constructed mixture combination
- Designing validation experiments that adequately cover a user-selected factor space
- Providing an efficient strategy for preparing the desired mixtures (i.e., mixture calculations)
- Providing performance-based metrics to aid a laboratory in examining different AT methods and choosing the optimal one for the casework they commonly encounter
- Calculating and reporting various metrics: average peak heights; % of profile recovered; drop-out events; and drop-in events
- Visualizing the resulting data.
The program is in the very early stages of development, but we would like to distribute it for user feedback and improvements. If you are interested in testing and providing feedback, please make a request through MixMaSTR [at] nist.gov (MixMaSTR[at]nist[dot]gov)
Major Accomplishments
Sarah Riman's MixMaSTR presentation at the Forensic DNA Continuing Education Day 2025
MixMaSTR: a Software Package for Designing and Interpreting Forensic DNA Validation Studies
Sarah Riman, Hari Iyer, Sarra Chouder, Edgar Robitaille, Benjamin Long, Peter Vallone
Gordon Research Conference - Forensic Analysis of Human DNA (Newry, ME), June 22, 2025-June 27, 2025