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Material Measurement Laboratory

Projects/Programs

Displaying 476 - 500 of 569

Serology and Neutralization Assays for COVID-19

Ongoing
Multiplexed bead-based SARS-CoV-2 serological assay We have developed a validated multiplexed bead-based SARS-CoV-2 serological assay that measures different antibodies produced by a patient (IgG, IgM, IgA). In collaboration with the NIST Applied and Computational Mathematics Division, we have

Single-Cell Manipulation and Measurement

Ongoing
Mammalian cells are an important source material for applications in regenerative medicine, gene therapy, engineering biology, and genome editing. Traditional tools for manipulating mammalian cells operate at a bulk cell population level without precision manipulation of individual cells
word Thermodynamics on a puzzle pieces

Solvation Thermodynamics

Ongoing
Solvation thermodynamics data are essential in the characterization and interpretation of any process carried out in the liquid phase. The data have application in the study of biochemical processes such as protein folding and protein-protein association in aqueous fluids and are useful as

Springback

Ongoing
Springback, or the elastic change in shape when a part is released from the manufacturing process, has been a problem for decades and accounts for a significant fraction of the expense that the US auto industry spends each year trying out die sets for new body designs. The inability to predict the
Photograph of a packaged unit of SRM 2700 Hexavalent chromium in Contaminated Soil (low Level)

Standard Reference Materials for Hexavalent Chromium in Contaminated Soil

Completed
During the last century, chromate and dichromate chemical production facilities processed considerable amounts of chromite ore for industrial manufacturing purposes. The waste material from these operations called chromite ore processing residue (COPR) was disposed of in waste sites across the
drop

Standard Reference Measurements

Ongoing
State-of-the art property measurements have been the hallmark of the Fluid Properties Group for more than four decades. Many of these measurements have been carried out on one-of-a-kind instruments developed at NIST. In some cases the older instruments are still among the very best of their kind
Photograph of SRM 3103a showing a labeled clear glass ampoule and labeled box against a blue background.

Standard Solution SRMs Provide Traceability for Millions of Measurements

Ongoing
Literally millions of measurements of elemental composition are performed each year worldwide. The vast majority of these measurements depend upon reference materials for establishing traceability of results to the SI. Leveraged through commercial CRM producers, the NIST SRM 3100 series provides an

Standards

Ongoing
Standards for Optical Based Standoff Detection NIST is researching methods for creating explosive threat materials standards relevant to optical detection technologies (e.g. that result in samples with particle morphologies similar to those found in explosive threat devices). This includes both
Breathalyzer

Standards Development to Ensure Reliable Breath Analysis in the Field

Ongoing
Numerous volatile organic compounds (VOCs) have been identified in human breath. These compounds can be produced by the body or by organisms in the body (e.g., bacteria or viruses) and provide a non-invasive window into human health. Inexpensive point-of-care devices are being developed to diagnose
Metagenomics Workflow

Standards for Metagenomics

Ongoing
Metagenomics is a powerful technology combining high-throughput (a.k.a. “next-generation”) sequencing with advanced bioinformatics to identify and quantify mixtures of organisms in a sample. Metagenomics workflows consist of 4 main steps: Sample collection: location, amount, storage, etc. Extraction

Standards to Support Biological Detection in the Field

Ongoing
NIST is working in partnership with the Department of Homeland Security Science and Technology Directorate (DHS S&T) to develop methods, guidance, standards, and reference materials to support and improve our Nation's ability to detect and respond to suspected biothreat incidents. Specific
First responders collecting samples of the yeast surrogate material during a field exercise. (Credit: NIST)

Standards to Support Biothreat Detection

Ongoing
Since 9/11 and the subsequent anthrax attacks in 2001, suspicious white powder incidents continue to occur within the US, often requiring Federal law enforcement response. Suspect samples are sent to public health laboratories for confirmatory evaluation, which can take hours to weeks to receive

Statistical methods for MGI metrology

Ongoing
We focus on research and development of statistical methods to enable new measurement science and metrology relevant to MGI. In particular, we illustrate our methods for examples from near-field scanning probe microwave microscopy (NSSM) for characterization, development, and modeling of novel
This figure shows a microscopic image of a field of cells, some of which are pseudocolored red to indicate that these cells remain pluripotent.

Stem Cell Metrology: WSDOM

Ongoing
Stem cells are critical starting materials for advanced therapies and diagnostic devices. The most commonly used are induced pluripotent stem cells (iPSCs) which can be created with any individual’s skin cells, and then can be coaxed to become cells for any tissue of the body. Therapies and
Steroid Hormone Pathway Mapping

Steroid Hormone Suite Analysis

Ongoing
Steroid hormones are signaling molecules that are major regulators of development, reproduction, stress, and growth. Steroids are synthesized from cholesterol through a series of enzymes, resulting in hormones with distinct biological activities. Although hormones are similar in structure, and

Stochastic Network Growth Simulation for Photopolymerization

Ongoing
We have developed a computational method to simulate the complex interactions of the stochastic processes during polymerization. Specifically, the firing rates of these stochastic events are determined based on monomer information ( e.g. functionalities, rate constants, diffusivities, interaction

Storage Stability of Freeze-Dried Proteins

Completed
Intended Impact Work in this project will enable industry to develop rational formulation approaches for freeze-drying, thus facilitating the manufacture safer, longer lasting biopharmaceuticals, with less time and resource cost required for stabilization. Biopharmaceuticals are the fastest growing
Images depicting an advanced analysis of HR-EBSD data

Strain Measurement for Semiconductor Devices and Packages

Ongoing
Strain is a critical parameter that influences both electrical and mechanical failures of devices, however, measuring strain in complex 3D geometries and vanishingly small feature sizes remains a challenge for manufacturers. Data provided by strain measurements can be used to validate computational
EBSD measurement on 63nm SiGe line

Strain Measurement for Semiconductor Devices

Ongoing
Mechanical strain is hugely important to semiconductor devices and packages while also being difficult to measure accurately. Strain is engineered into CMOS channels to improve carrier mobility for higher performance at lower power but is also intrinsically present from manufacturing processes where

Strategy for extensible, evolving terminology for MGI efforts

Ongoing
Many Indo-European languages utilize a limited set of highly reused, non-synonymous, short semantically relevant words called roots that can be combined to facilitate the building of new compounded terms such as peanut butter and watch dog. This approach, which is more prominent in certain languages

Stroboscopic TEM for Ultrafast Materials Science

Ongoing
Our people: June Lau co-invented the stroboscopic microscope and had been with this project since inception. She is a physicist, and the PI of this project. She received 2 non-provisional patents for the design of the microscope, and one provisional patent on a specimen holder for microwave delivery
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