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This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins
The National Institute of Standards and Technology (NIST) established a Health Assessment Measurements Quality Assurance Program (HAMQAP), in part as a
Nature utilizes a hierarchy of length scales and tiered structure to build lightweight, strong, and tough materials. Engineers look to exploit the advantage of
Ferromagnet-based microelectronic devices play an increasingly important role within the semiconductor ecosystem. Magnetic RAM (MRAM) is already replacing
Climate science increasingly relies on satellite- and ground-based spectrometers for the top-down inventories of atmospheric greenhouse gases, most notably
Recent innovative advances in the design and manufacture of isotope ratio mass spectrometers (IRMS) have revolutionized the study of natural and man-induced
Atomic arrangements underpin the properties of all solids and, as such, are fundamentally important for materials development. The power of computational
New biological drugs such as peptide drugs, antibody drug conjugates, and vaccines are emerging to fill pharmaceutical voids. They are typically prepared in
We develop combinatorial measurement methods and metrologies for the rapid generation of comprehensive and consistent datasets. Manufacturers of devices based
The Organic Chemical Metrology Program exists within the Chemical Sciences Division, MML, which is located at the Hollings Marine Laboratory in Charleston, SC.
To identify new biomarkers that may serve as disease indicators and to understand biologically relevant properties of the human gut microbiome, we need
Many polymeric fluids, including biotherapeutics and fuels, can have unusual physical behavior in solutions, and many applications require detailed knowledge of
NIST is measuring the trace chemical signatures and quantities of trace residues and background levels that contaminate surfaces associated with the concealment
Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important missing element in
Using high-performance inductively coupled plasma optical emission spectrometry (HP‑ICP-OES), relative expanded uncertainties on the order of 0.2 % can be
We develop first-principles-based methods for prediction of atomic arrangements and properties in advanced materials and develop tools for the prediction and
The ability to deposit small amounts of material in a highly controllable and precise fashion is important for creating test materials for trace detection
Compile and evaluate phase equilibrium data for NIST Standard Reference Database 31 (Phase Equilibria Diagrams); disseminate the data in a readily accessible
The overarching goal of this project is to develop and disseminate measurement tools to improve the accuracy and reliability of chemical measurements related to
New materials are essential for future energy independence, environmental sustainability, and next-generation manufacturing. The Materials Genome Initiative
NIST invites participants to an Interlaboratory Testing Program to evaluate the suitability and utility of the genomic DNA test materials to serve as reference
The increased performance of modern computational systems has enabled the size and time scales of materials models to be increased significantly. In parallel