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Health

Dentistry

News and Updates

Projects and Programs

Chain orientation of polyethylene by polarization BCARS

3D Molecular Orientation Imaging

Ongoing
We have developed 3D orientation measurement techniques by analyzing polarization-dependent molecular vibrational signals based on infrared (IR) absorption [1,2] and coherent anti-Stokes Raman scattering (CARS) [3]. The two imaging modalities are complementary to each other: IR imaging broadly...
A schematic overview showing the distribution of the standardized samples to study participants, the use of standardized protocols for measurements, and standardized reporting of data back to NIST for analysis.

AAPS Interlaboratory Study: Protein Aggregation and Immunogenicity

Ongoing
To ensure the safety and efficacy of protein-based biotherapeutics, manufacturers strive to avoid unwanted immune responses caused by the biotherapeutic. Protein immunogenicity is a complex topic and depends on multiple factors related to the product, patient profile, and treatment. 1 , 2...

Advanced Spectral Analysis: Two-Dimensional Correlation Spectroscopy (2DCOS)

Ongoing
When a series of spectra are acquired from a sample as a function of temperature, pressure, electric field strength, concentration, or any experimental parameters, conventional spectral analysis is performed by monitoring the intensity change at a specific frequency. However, such a single frequency...
Optical coherence tomography

Biofabrication of Tissue Engineered Constructs

Ongoing
OCT imaging was assessed using a model scaffold-cell system consisting of a polysaccharide-based hydrogel seeded with human Jurkat cells. Four test systems were used: hydrogel seeded with live cells, hydrogel seeded with heat-shocked or fixed dead cells and hydrogel without any cells. Time series...

Publications

Interlaboratory Comparison with a Reference Measurement Procedure (RMP) for Determining 24,25-Dihydroxvitamin D3 in Human Serum using Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Author(s)
Stephen Wise, Ekaterina Mineva, Christine Pfeiffer, Hubert Vesper, Etienne Cavalier, Stephenie Peters, Karen Galvin, Kevin Cashman, Andrew Norbert Hoofnagle, Hsuan-Chieh (Joyce) Liao, Emma Williams, Laura Briggs, Adam Kuszak, Grace Hahm, Johanna Camara
An interlaboratory comparison study was conducted among five laboratories for determination of 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] in human serum using...

Breast imaging with ultra-low field MRI

Author(s)
Sheng Shen, Neha Koonjoo, Friderike Longarino, Mansi Saksena, Torben Hornung, Stephen Ogier, Susu Yan, Thomas Bortfeld, Kathryn Keenan, Matthew Rosen

Software

Screenshot of NIST Mass and Fragment Calculator Software

NIST Mass and Fragment Calculator Software

The NIST Mass and Fragment Calculator is a program written in Visual Basic which calculates the mass of an input peptide or protein sequence along with m/z ions
isotope calc

Isotope Enrichment Calculator

The NIST Isotope Enrichment Calculator is a program written in Visual Basic which determines the percentage of 15N enrichment of stable isotope-labeled peptides
AutoDimer logo

AutoDimer

The web-based AutoDimer software was developed to rapidly screen previously selected PCR primers for primer-dimer and hairpin interactions in short DNA

Awards

Ram Sriram

Ram Sriram Named IEEE Fellow

Ram D. Sriram, Chief of ITL’s Software and Systems Division, has been named an Institute of Electrical and Electronics Engineers (IEEE) Fellow, effective January 1, 2017, for leadership in developing computational tools for healthcare enterprises...
Anne Plant

Anne Plant Elected AAAS Fellow

MML Division Chief Dr. Anne Plant has been elected to the rank of fellow of the American Association for the Advancement of Science (AAAS) by the AAAS Council. Plant was recognized for "distinguished contributions to the field of quantitative biology...
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