Pharmaceuticals

News and Updates

A man in a lab coat and safety glasses looks up at petri dishes he is holding.

Spotlight: Scott Jackson’s Living in a Microbial World

August 4, 2021

Scott Jackson is not alone in this picture. It’s him, and his microbiome. The human microbiome is defined as all the microbes that live in and on the human body

Identifying Individual Molecules: NIST Study Suggests How to Build a Better ‘Nanopore’ Biosensor

April 27, 2021

Researchers have spent more than three decades developing and studying miniature biosensors that can identify single molecules. In five to 10 years, when such

NIST Puts New Biopharmaceutical Quality Control Method to the Test

March 29, 2021

A new method for monitoring biopharmaceutical product quality was recently put to the test by The National Institute of Standards and Technology (NIST) and 28

Projects and Programs

Reliable Vaccine Storage

We study provider-level vaccine storage and temperature monitoring methods to develop best practice guidance for public health audiences.

WG4 Bioprocessing

Within bioprocessing, Working Group 4 has currently identified standardization needs in four major technology spaces: 1) component materials control; 2)

Nanoparticle Metrology in Complex Cellular Environments

This project, now concluded, developed novel imaging and image analysis tools to examine individual cells and cell populations within the complex chemical

Monoclonal Antibody Mass Spectral Libraries

The National Institute of Standards and Technology is developing a mass spectral library of all identifiable components derived from the digestion of monoclonal

Publications

An assessment of US microbiome research

September 23, 2021

Author(s)

Scott Jackson

Genome-enabled technologies have supported a dramatic increase in our ability to study microbial communities in environments and hosts. Taking stock of

Comprehensive Analysis of Tryptic Peptides Arising from Disulfide Linkages in NISTmAb and Their Use for Developing a Mass Spectral Library

June 22, 2021

Author(s)

Qian Dong, Xinjian Yan, Yuxue Liang, Sanford Markey, Sergey L. Sheetlin, Concepcion Remoroza, William E. Wallace, Stephen Stein

This work presents methods for identifying and then creating a mass spectral library for disulfide-linked peptides originating from the NISTmAb. Analysis

Principal Component Analysis of 1D ¹H Diffusion Edited NMR Spectra of Protein Therapeutics.

June 20, 2021

Author(s)

Korth Elliott, Frank Delaglio, Mats Wikstrom, John Marino, Luke Arbogast

The one-dimensional (1D) diffusion edited proton NMR method, Protein Fingerprint by Lineshape Enhancement (PROFILE) has been demonstrated to be suitable for

Design, Synthesis, and Biological Evaluation of Novel 1,3-Oxazole Sulfonamides as Tubulin Polymerization Inhibitors

June 17, 2021

Author(s)

Edward Sisco, Korry Barnes

A series of novel 1,3-oxazole sulfonamides were constructed and screened for their potential to inhibit cancer cell growth. These compounds were evaluated