Pharmaceuticals

News and Updates

Identifying Individual Molecules: NIST Study Suggests How to Build a Better ‘Nanopore’ Biosensor

April 27, 2021

Researchers have spent more than three decades developing and studying miniature biosensors that can identify single molecules. In five to 10 years, when such

NIST Puts New Biopharmaceutical Quality Control Method to the Test

March 29, 2021

A new method for monitoring biopharmaceutical product quality was recently put to the test by The National Institute of Standards and Technology (NIST) and 28

A red cylinder made of lipids has five protruding multicolored proteins.

NIST Clarifies Structure of Prospective Vaccine for Respiratory Virus

December 16, 2020

No approved vaccine exists for RSV, a life-threatening virus that attacks the respiratory system. State-of-the-art neutron and X-ray scattering performed at the

Projects and Programs

Reliable Vaccine Storage

We study provider-level vaccine storage and temperature monitoring methods to develop best practice guidance for public health audiences.

Polymer Suspensions & Emulsions

The goals of this project are to improve measurements of fluid structure and mechanical properties under a variety of flow conditions. We focus on fluids and

WG4 Bioprocessing

Within bioprocessing, Working Group 4 has currently identified standardization needs in four major technology spaces: 1) component materials control; 2)

Nanoparticle Metrology in Complex Cellular Environments

This project, now concluded, developed novel imaging and image analysis tools to examine individual cells and cell populations within the complex chemical

Publications

NIST Recommended Practice Guide: Fractography of Ceramics and Glasses, 3rd edition

September 15, 2020

Author(s)

George D. Quinn

Fractography is a powerful but underutilized tool for the analysis of fractured glasses and ceramics, for fractures in the laboratory and for component failures

Effect of thermal ballast loading on temperature stability of domestic refrigerators used for vaccine storage

July 8, 2020

Author(s)

Michal J. Chojnacky, Alexandra L. Rodriguez

Vaccine temperature control failures represent a significant public and private healthcare cost. Vaccines damaged by excessive heat or freezing lose their

Chemometric Outlier Classification of 2D-NMR Spectra to Enable Higher Order Structure Characterization of Protein Therapeutics

April 15, 2020

Author(s)

David A. Sheen, Vincent K. Shen, Robert G. Brinson, Luke W. Arbogast, John P. Marino, Frank Delaglio

Protein therapeutics are vitally important clinically and commercially, with monoclonal antibody (mAb) therapeutic sales alone accounting for $115 billion in

Highland Games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from DNA sequences

April 7, 2020

Author(s)

John E. Schiel, Coffman Jon, Bruno Marques, Griesbach Jan, Ambrose Williams, Gisela Ferreira, Rushd Khalaf, David Roush, Charles Haynes

Biopharmaceutical product and process development does not yet take advantage of predictive computational modeling to nearly the degree seen in industries based