Pharmaceuticals

News and Updates

A red cylinder made of lipids has five protruding multicolored proteins.

NIST Clarifies Structure of Prospective Vaccine for Respiratory Virus

December 16, 2020

No approved vaccine exists for RSV, a life-threatening virus that attacks the respiratory system. State-of-the-art neutron and X-ray scattering performed at the

A new twist on measuring spin: NIST Develops Microresonator to Study Electron Spin in Small Volumes

November 17, 2020

Researchers at the National Institute of Standards and Technology (NIST) have developed a device to detect a quantum property of electrons, known as spin, in

NIST Scientists Get Soft on 3D Printing

September 22, 2020

Researchers at the National Institute of Standards and Technology (NIST) have developed a new method of 3D-printing gels and other soft materials. Published in

Projects and Programs

Live Cell Imaging of Induced Pluripotent Stem Cell Populations

Induced pluripotent stem cell (iPSC) populations are complex, dynamic and heterogeneous. Individual cells within a population are constantly changing, while

NIST20: Updates to the NIST Tandem and Electron Ionization Spectral Libraries

The latest release of the NIST Mass Spectral Library, which includes the NIST Tandem Mass Spectral Library and NIST/EPA/NIH Mass Spectral Library and NIST GC

HDX-MS for Biopharmaceutical Analysis

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins

WG1 Terminology

Working Group 1 will work on identification of currently used national and international standards, guidelines and other relevant documents, as well as terms

Publications

NIST Recommended Practice Guide: Fractography of Ceramics and Glasses, 3rd edition

September 15, 2020

Author(s)

George D. Quinn

Fractography is a powerful but underutilized tool for the analysis of fractured glasses and ceramics, for fractures in the laboratory and for component failures

Effect of thermal ballast loading on temperature stability of domestic refrigerators used for vaccine storage

July 8, 2020

Author(s)

Michal J. Chojnacky, Alexandra L. Rodriguez

Vaccine temperature control failures represent a significant public and private healthcare cost. Vaccines damaged by excessive heat or freezing lose their

Chemometric Outlier Classification of 2D-NMR Spectra to Enable Higher Order Structure Characterization of Protein Therapeutics

April 15, 2020

Author(s)

David A. Sheen, Vincent K. Shen, Robert G. Brinson, Luke W. Arbogast, John P. Marino, Frank Delaglio

Protein therapeutics are vitally important clinically and commercially, with monoclonal antibody (mAb) therapeutic sales alone accounting for $115 billion in

Highland Games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from DNA sequences

April 7, 2020

Author(s)

John E. Schiel, Coffman Jon, Bruno Marques, Griesbach Jan, Ambrose Williams, Gisela Ferreira, Rushd Khalaf, David Roush, Charles Haynes

Biopharmaceutical product and process development does not yet take advantage of predictive computational modeling to nearly the degree seen in industries based