Pharmaceuticals

News and Updates

NIST Awards Funding to Strengthen Advanced Manufacturing for Microelectronics, Digital and Biomanufacturing

April 1, 2022

GAITHERSBURG, Md. — The U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) has awarded a total of $1.2 million to four

Commerce Department Awards $54 Million in American Rescue Act Grants to Increase Access to Advanced Manufacturing Opportunities

February 28, 2022

GAITHERSBURG, Md. — The U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) has awarded nearly $54 million in grants for 13 high

New NIST Reference Material Helps Manufacturers Better Assess Their Biological Drug Products

November 15, 2021

Sugars not only provide nourishment in the food you eat but can also act as biomarkers for detecting disease. When certain types of simple sugars, such as

Projects and Programs

Reliable Vaccine Storage

Ongoing

We study provider-level vaccine storage and temperature monitoring methods to develop best practice guidance for public health audiences.

Monoclonal Antibody Mass Spectral Libraries

Ongoing

The National Institute of Standards and Technology is developing a mass spectral library of all identifiable components derived from the digestion of monoclonal

Improved Benchtop Connectivity to Complex Microfluidic Devices

Ongoing

Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important missing element in

Cell Counting for Cell Therapies

Ongoing

Cell counting (or cell enumeration) is one of the most fundamental measurements in biotechnology, from biomanufacturing to medical diagnosis to advanced therapy

Publications

HDX-MS and MD simulations provide evidence for stabilization of the IgG1— FcγRIa (CD64a) immune complex through intermolecular glycoprotein bonds

December 8, 2021

Author(s)

Kyle Anderson, Kerry Scott, Christina Bergonzo, Ioannis Karageorgos, Elyssia Gallagher, Venkata Tayi, Michael Butler, Jeffrey W. Hudgens

Previous reports present different models for the stabilization of the Fc—FcγRI immune complex. Although accord exists on the importance of L235 in IgG1 and

An assessment of US microbiome research

September 23, 2021

Author(s)

Scott Jackson

Genome-enabled technologies have supported a dramatic increase in our ability to study microbial communities in environments and hosts. Taking stock of

Comprehensive Analysis of Tryptic Peptides Arising from Disulfide Linkages in NISTmAb and Their Use for Developing a Mass Spectral Library

June 22, 2021

Author(s)

Qian Dong, Xinjian Yan, Yuxue Liang, Sanford Markey, Sergey L. Sheetlin, Concepcion Remoroza, William E. Wallace, Stephen Stein

This work presents methods for identifying and then creating a mass spectral library for disulfide-linked peptides originating from the NISTmAb. Analysis

Principal Component Analysis of 1D ¹H Diffusion Edited NMR Spectra of Protein Therapeutics.

June 20, 2021

Author(s)

Korth Elliott, Frank Delaglio, Mats Wikstrom, John Marino, Luke Arbogast

The one-dimensional (1D) diffusion edited proton NMR method, Protein Fingerprint by Lineshape Enhancement (PROFILE) has been demonstrated to be suitable for