Pharmaceuticals

News and Updates

New NIST Reference Material Helps Manufacturers Better Assess Their Biological Drug Products

November 15, 2021

Sugars not only provide nourishment in the food you eat but can also act as biomarkers for detecting disease. When certain types of simple sugars, such as

A man in a lab coat and safety glasses looks up at petri dishes he is holding.

Spotlight: Scott Jackson’s Living in a Microbial World

August 4, 2021

Scott Jackson is not alone in this picture. It’s him, and his microbiome. The human microbiome is defined as all the microbes that live in and on the human body

Identifying Individual Molecules: NIST Study Suggests How to Build a Better ‘Nanopore’ Biosensor

April 27, 2021

Researchers have spent more than three decades developing and studying miniature biosensors that can identify single molecules. In five to 10 years, when such

Projects and Programs

Reliable Vaccine Storage

Ongoing

We study provider-level vaccine storage and temperature monitoring methods to develop best practice guidance for public health audiences.

U.S. TAG for ISO/TC276: Biotechnology

The primary goal of the US Technical Advisory Group (US TAG) to International Organization for Standardization (ISO) Technical Committee (TC) 276 Biotechnology

WG3 Analytical Methods

Ongoing

The ISO/TC 276/WG 3 Analytical methods aims to develop standards for accurate, reproducible and robust measurement and analysis in support of biotechnology.WG 3

Protein rheology measurements

Ongoing

Therapeutic protein solutions are highly concentrated during manufacturing purification processes and in finished dosage. At such concentrations, the fluid

Publications

HDX-MS and MD simulations provide evidence for stabilization of the IgG1— FcγRIa (CD64a) immune complex through intermolecular glycoprotein bonds

December 8, 2021

Author(s)

Kyle Anderson, Kerry Scott, Christina Bergonzo, Ioannis Karageorgos, Elyssia Gallagher, Venkata Tayi, Michael Butler, Jeffrey W. Hudgens

Previous reports present different models for the stabilization of the Fc—FcγRI immune complex. Although accord exists on the importance of L235 in IgG1 and

An assessment of US microbiome research

September 23, 2021

Author(s)

Scott Jackson

Genome-enabled technologies have supported a dramatic increase in our ability to study microbial communities in environments and hosts. Taking stock of

Comprehensive Analysis of Tryptic Peptides Arising from Disulfide Linkages in NISTmAb and Their Use for Developing a Mass Spectral Library

June 22, 2021

Author(s)

Qian Dong, Xinjian Yan, Yuxue Liang, Sanford Markey, Sergey L. Sheetlin, Concepcion Remoroza, William E. Wallace, Stephen Stein

This work presents methods for identifying and then creating a mass spectral library for disulfide-linked peptides originating from the NISTmAb. Analysis

Principal Component Analysis of 1D ¹H Diffusion Edited NMR Spectra of Protein Therapeutics.

June 20, 2021

Author(s)

Korth Elliott, Frank Delaglio, Mats Wikstrom, John Marino, Luke Arbogast

The one-dimensional (1D) diffusion edited proton NMR method, Protein Fingerprint by Lineshape Enhancement (PROFILE) has been demonstrated to be suitable for