Publications

Displaying 26 - 43 of 43

Detection and identification of sugar alcohol sweeteners by ion mobility spectrometry

June 23, 2016

Author(s)

Thomas Forbes, Edward Sisco, Christopher Browne

The rapid and sensitive detection of sugar alcohols sweeteners was demonstrated using ion mobility spectrometry (IMS). IMS provides a valuable compromise in sensitivity, cost, and analysis speed between centralized liquid chromatography-mass spectrometry

Ion trap mobility spectrometry nuisance alarm threshold analysis for illicit narcotics based on environmental background and a ROC-curve approach

May 18, 2016

Author(s)

Thomas Forbes, Marcela N. Najarro

The discriminative potential of an ion trap mobility spectrometer (ITMS) for trace detection of illicit narcotics relative to environmental background was investigated with a receiver operator characteristic (ROC) curve framework. The ITMS response of

Analysis of Potential Homemade Nitrate Ester Explosive By-products via Direct Analysis in Real Time Mass Spectrometry

December 9, 2015

Author(s)

Edward Sisco, Thomas Forbes

This work demonstrates the ability of off-axis direct analysis in real time mass spectrometry (DART-MS) to detect five representative homemade nitrate ester explosive by-products. Instrumental parameters that were examined included mass spectrometer

In-source collision induced dissociation of inorganic explosives for mass spectrometric signature detection and chemical imaging

September 23, 2015

Author(s)

Thomas P. Forbes, Edward R. Sisco

In-source collision induced dissociation (CID) coupled with laser desorption/ionization mass spectrometry (LDI-MS) demonstrated the trace detection, bulk quantification, and chemical imaging of inorganic explosives and components. The incorporation of in

A Novel Test Sample for the Quantification of Illicit Drugs in Fingerprints using Imaging Mass Spectrometry

April 27, 2015

Author(s)

Shinichiro Muramoto, Thomas Forbes, Arian C. van Asten, John Gillen

A novel standard for the forensic analysis of fingerprints was introduced and characterized using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and desorption electrospray ionization mass spectrometry (DESI-MS), aimed at the trace level

Trace detection and competitive ionization of erythritol tetranitrate in mixtures using direct analysis in real time mass spectrometry

April 9, 2015

Author(s)

Thomas P. Forbes, Edward R. Sisco

Direct analysis in real time (DART) mass spectrometry was used for trace detection of the nitrate ester explosive, erythritol tetranitrate (ETN), and its sugar alcohol precursor, erythritol. The present investigation revealed the impact of competitive

Rapid Detection of Sugar Alcohol Precursors and Corresponding Nitrate Ester Explosives using Direct Analysis in Real Time Mass Spectrometry

March 30, 2015

Author(s)

Edward Sisco, Thomas Forbes

This work highlights the rapid detection of nitrate ester explosives and their sugar alcohol precursors by direct analysis in real time mass spectrometry (DART-MS) using an off-axis geometry. Demonstration of the effect of various parameters, such as ion

Rapid Detection and Isotopic Measurement of Discrete Inorganic Samples using Acoustically Actuated Droplet Ejection and Extractive Electrospray Ionization Mass Spectrometry

December 2, 2014

Author(s)

Thomas P. Forbes

The coupling of ultrasonic nebulization and extractive electrospray ionization (EESI) for the mass spectrometric (MS) detection and analysis of inorganic compounds from discrete liquid samples was demonstrated. The rapid detection, high throughput

Mass Spectrometry Detection and Imaging of Organic and Inorganic Explosive Device Signatures using Desorption Electro-Flow Focusing Ionization

June 26, 2014

Author(s)

Thomas Forbes, Edward Sisco

We demonstrate the coupling of desorption electro-flow focusing ionization (DEFFI) with in-source collision induced dissociation (CID) for the mass spectrometric (MS) detection and imaging of explosive device components, including both organic, e.g

Chemical Imaging of Artificial Fingerprints by Desorption Electro-Flow Focusing Ionization Mass Spectrometry

May 19, 2014

Author(s)

Thomas Forbes, Edward Sisco

Desorption electro-flow focusing ionization (DEFFI) mass spectrometry was used to image chemical distributions of endogenous, e.g., fatty acids, and trace exogenous compounds, e.g., explosives, narcotics and lotions, in deposited and lifted artificial

Characterization of Emerging Ambient Pressure Mass Spectrometric Techniques using Time-of-Flight Secondary Ion Mass Spectrometry

March 28, 2014

Author(s)

Shinichiro Muramoto, Thomas P. Forbes, Matthew E. Staymates, John G. Gillen

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) was used to characterize the desorption performance of two emerging ambient ionization mass spectrometry (MS) sources; desorption electrospray ionization (DESI) and low temperature plasma (LTP)

Desorption Electro-Flow Focusing Ionization of Explosives and Narcotics for Ambient Pressure Mass

August 6, 2013

Author(s)

Thomas Forbes, Timothy M. Brewer, John Gillen

Desorption electro-flow focusing ionization (DEFFI), a desorption-based ambient ion source, was developed and evaluated as a possible source for field deployable ambient pressure mass spectrometry (APMS). DEFFI, based on an electro-flow focusing system

Theoretical Analysis of a Magnetophoresis-Diffusion T-Sensor Immunoassay

August 6, 2013

Author(s)

Thomas P. Forbes, Matt S. Munson, Samuel P. Forry

Microfluidic immunoassays have demonstrated broad application to the detection and quantification of analytes ranging from small drug molecules to large proteins and biomolecules. These systems exhibit short length scales, reduced sample volumes, and

Capturing Rare Cells From Blood Using a Packed Bed of Custom-Synthesized Chitosan Microparticles

July 1, 2013

Author(s)

Chandamany Arya, Jason Kralj, Kunqiang Jiang, Matt S. Munson, Thomas Forbes, Don L. DeVoe, Srinivasa R. Raghavan, Samuel Forry

Uniform multifunctional chitosan microparticles were produced in large numbers using a simple and inexpensive microtubing arrangement. The particles were functionalized through both physical encapsulation of carbon black, to attenuate autofluorescence, and

Primary and Secondary Droplet and Charge Transmission Characteristics of Desorption Electro-Flow Focusing Ionization

May 28, 2013

Author(s)

Thomas P. Forbes, Timothy M. Brewer, John G. Gillen

We present the investigation of droplet charging and charge transmission characteristics of an electro-flow focusing nozzle for desorption-based ambient ionization mass spectrometry. The electro-flow focusing geometry utilizes a concentrically flowing gas

Simple device for rare cell capture from whole blood

September 26, 2012

Author(s)

Jason G. Kralj, Samuel P. Forry, Matt S. Munson, Thomas P. Forbes, Chandamany Arya, Lynn Sorbara, Alessandro Tona, Sudhir Srivastava

We have developed a system to isolate rare cells from whole blood using commercially available components and simple microfluidics that can provide biologists with the capabilities of the monolithic devices. We characterized the capture of MCF-7 cells

Engineering and Analysis of Surface Interactions in a Microfluidic Herringbone Micromixer

May 18, 2012

Author(s)

Thomas P. Forbes, Jason G. Kralj

We developed a computational model and theoretical framework to investigate the geometrical optimization of particle-surface interactions in a herringbone micromixer. The enhancement of biomolecule- and particle-surface interactions in microfluidic devices

Microfluidic magnetophoretic separations of immunomagnetically labeled rare mammalian cells

February 13, 2012

Author(s)

Thomas P. Forbes, Samuel P. Forry

Immunomagnetic isolation and magnetophoresis in microfluidics have emerged as viable techniques for the separation, fractionation, and enrichment of rare cells. Here, we present the development and characterization of a microfluidic system that

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