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Search Publications by: Richard E Cavicchi (Fed)

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Displaying 1 - 25 of 85

Distribution of Average Aggregate Density from Stir-stressed NISTmAb Protein

March 19, 2022
Author(s)
Richard E. Cavicchi, Laura Philips, Fook Cheong, David Ruffner, Priya Kasimbeg, Wyatt N. Vreeland
Quantifying the heterogeneous nature of protein aggregates is important to understanding the impact aggregates may have on the performance of antibody therapeutics. The spatially averaged density p of aggregates, defined as the total mass, including water

Phase-Appropriate Application of Analytical Methods to Monitor Subvisible Particles Across the Biotherapeutic Drug Product Life Cycle

October 30, 2019
Author(s)
Roman Mathaes, Linda Narhi, Andrea Hawe, Anja Matter, Karoline Bechtold-Peters, Sophia Kenrick, Sambit Kar, Olga Laskina, John Carpenter, Richard E. Cavicchi, Ellen Koepf, Neil Lewis, Rukman De Sliva, Dean C. Ripple
The phase-appropriate application of analytical methods to characterize, monitor, and control particles is an important aspect of the development of safe and efficacious biotherapeutics. The AAPS Product Attribute and Biological Consequences (PABC) focus

Initiation of flash boiling of multicomponent miscible mixtures with application to transportation fuels and their surrogates

August 16, 2018
Author(s)
Charles T. Avedisian, Kyle Skyllingstad1, Richard E. Cavicchi, Corinne Lippe, Michael J. Carrier
This paper presents methodologies to predict thermodynamic conditions that initiate flash boiling by spontaneous nucleation of liquids consisting of hundreds of miscible liquids and their lower order surrogate mixtures. The methods are illustrated with a

Rapid Detection of Thin-Film Interfacial Reactions by MEMS-DSC

February 19, 2017
Author(s)
Lawrence P. Cook, Richard E. Cavicchi, Yanbao Zhang, Mark D. Vaudin, Christopher B. Montgomery, William F. Egelhoff Jr., Martin L. Green, Leslie Allen
A MEMS-based differential scanning calorimeter (DSC) has been used to characterize the Ni/Si interfacial reaction in thin films at ramp rates of 940 C/s and 3760 C/s. The DSC devices were fabricated using CMOS semiconductor processing technology, and were

Variable Threshold Method for Determining the Boundaries of Imaged Subvisible Particles

February 15, 2017
Author(s)
Richard E. Cavicchi, Cayla Collett, Srivalli Telikepalli, Zhishang Hu, Michael J. Carrier, Dean C. Ripple
An accurate assessment of particle characteristics and concentrations in pharmaceutical products by flow imaging requires accurate particle sizing and morphological analysis. Analysis of images begins with the definition of particle boundaries from the

Rapid evaporation at the superheat limit of methanol, ethanol, butanol and n-heptane on platinum films supported by low-stress SiN membranes

June 7, 2016
Author(s)
Eric J. Ching, C. T. Avedisian, Richard E. Cavicchi, Do H. Chung, Jeff Rah, Michael J. Carrier
The bubble nucleation temperatures of several organic liquids (methanol, ethanol, butanol,n-heptane) on stress-minimized platinum (Pt) films supported by SiN membranes is examined by pulse-heating the membranes for times ranging from 1 υs to 10 υs. The

Bubble Nucleation of Highly Superheated Water on Thin Film Platinum Films supported by SiN Membranes using a Low-Noise Bridge Circuit

December 1, 2014
Author(s)
Eric J. Ching, Michael J. Carrier, C. T. Avedisian, James R. Young, Bruce R. Land, Richard E. Cavicchi
This study describes the use of stress-minimized thin film platinum (Pt) membrane configurations (200 nm thick, 150 μm long, 10 μm wide) for promoting bubble nucleation of water near its superheat limit. The membrane designs consist of Pt films deposited

The Metrology of Counting Protein Particles

July 13, 2013
Author(s)
Dean C. Ripple, Michael J. Carrier, Richard E. Cavicchi, Christopher B. Montgomery, Zhishang Hu
A common degradation pathway for protein-based drugs is the growth of protein aggregates or particles. Counting and characterization of these particles is needed to assure the quality, efficacy, and safety of this type of drug. The unusual physical

The Metrology of Counting Protein Particles

March 18, 2013
Author(s)
Dean C. Ripple, Michael J. Carrier, Richard E. Cavicchi, Christopher B. Montgomery, Zhishang Hu
A common degradation pathway for protein-based drugs is the growth of protein aggregates or particles. Counting and characterization of these particles is needed to assure the quality, efficacy, and safety of this type of drug. The unusual physical

Rapid-Heating of Ionic Energetic Materials using a Micro-Differential Scanning Device

July 10, 2011
Author(s)
Nicholas W. Piekiel, Richard E. Cavicchi, Michael R. Zachariah
We employ a microcalorimeter device to study the thermal decomposition of organic energetic materials at very high heating rates. The compact size of this device enables rapid heating rates and sensitive detection of thermal loads from very small samples

Calorimetric Sensors

April 15, 2011
Author(s)
Richard E. Cavicchi
The calorimetric gas sensor has evolved from a simple metal hot wire to a modern device fabricated using micromachining techniques. The principle of operation is to detect the heat evolved from combustible gases on the sensor surface. While the most widely

A Simple Method to Assess the Thermal Mechanisms Associated with a Fire Suppressant

April 1, 2010
Author(s)
Cary Presser, C Avedisian, J. Stiehl, Richard E. Cavicchi
A new screening concept is presented to evaluate the thermal effectiveness of fire suppressants (liquids and gases) for solid surface cooling (without vaporization for liquid suppressants) under well-controlled conditions. The concept is based on measuring

Enhanced Mass Transport in Ultra-Rapidly-Heated Ni/Si Thin-Film Multilayers

November 15, 2009
Author(s)
Lawrence P. Cook, Richard E. Cavicchi, Nabil Bassim, Susie Eustis, Winnie Wong-Ng, Igor Levin, Ursula R. Kattner, Carelyn E. Campbell, Christopher B. Montgomery, William F. Egelhoff Jr., Mark D. Vaudin
We have investigated multilayer and bilayer Ni/Si thin films by nano-differential scanning calorimetry (DSC) at ultra rapid scan rates, in a temperature-time regime not accessible with conventional apparatus. DSC experiments were completed at slower scan

High Temperature Electrical Resistance of substrate-supported Single Walled Carbon Nanotubes

January 1, 2008
Author(s)
Richard E. Cavicchi, C Avedisian, Paul M. McEuen, Xinjian Zhou, Wilbur S. Hurst, Joseph T. Hodges
We report the electrical characteristics of two substrate-supported metallic single walled carbon nanotubes (SWNT) at temperatures up to 573 K over a range of bias voltages for zero gate voltage in air under atmospheric pressure. At low voltages or high