Ripple, D.
, Carrier, M.
, Cavicchi, R.
, Montgomery, C.
and Hu, Z.
(2013),
The Metrology of Counting Protein Particles, Cal Lab: International Journal of Metrology
(Accessed September 19, 2024)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
The Metrology of Counting Protein Particles
Published
Author(s)
, , , , Zhishang Hu
Abstract
A common degradation pathway for protein-based drugs is the growth of protein aggregates or particles. Counting and characterization of these particles is needed to assure the quality, efficacy, and safety of this type of drug. The unusual physical attributes of protein particles lead to difficulties in obtaining accurate particle counts with traditional calibration standards and methods. We describe the development of instrument-response models, novel instrumentation, and novel reference materials to address this metrology issue.Citation
Cal Lab: International Journal of Metrology
Volume
20
Issue
3
Pub Type
Journals
Keywords
aggregate, light obscuration, microscopy, particle, pharmaceutical, protein, reference material
Citation
Issues
If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.
Created July 13, 2013, Updated February 19, 2017