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Displaying 751 - 775 of 2355

Machine Learning Strategy to Determine Cell Shape Phenotypes Associated with Micro-Environmental Cues

June 25, 2016
Author(s)
Desu Chen, Sumona Sarkar, Julian Candia, Carl G. Simon Jr., Wolfgang Losert, Joy P. Dunkers, Stephen J. Florczyk, Subhadip Bodhak, Meghan Driscoll
Cell morphology has been identified as a potential indicator of stem cell response and function in biomaterial environments. However, determination of cell shape phenotype in biomaterials is complicated by heterogeneous cell populations, heterogeneous

Identification of novel N-glycosylation sites at non-canonical protein consensus motifs

June 14, 2016
Author(s)
Mark S. Lowenthal, Kiersta S. Davis, Lisa E. Kilpatrick, Catherine A. Mouchahoir, Karen W. Phinney
N-glycosylation is well known to occur at asparagine residues in the canonical consensus sequence N-X-S/T, but has also been identified at a small number of N-X-C motifs including the Asn491 residue of human serotransferrin. Here we report additional novel

Extensive sequencing of seven human genomes to characterize benchmark reference materials

June 7, 2016
Author(s)
Justin M. Zook, Jennifer H. McDaniel, David N. Catoe, Lindsay Harris, Marc L. Salit
The Genome in a Bottle Consortium hosted by the National Institute of Standards and Technology, (NIST), is creating reference materials and data for human genome sequencing, as well as methods for genome comparison and benchmarking. Here, we describe a

Measurement of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human tissues by liquid chromatography/tandem mass spectrometry with isotope dilution

June 5, 2016
Author(s)
Pawel Jaruga, Guldal Kirkali, Prasad T. Reddy, Alessandro Tona, Bryant C. Nelson, Li Mengxia, David M. Wilson III, Erdem Coskun, M Miral Dizdar
Introduction DNA repair proteins may be used as biomarkers in disease etiology and therapy. Thus, the accurate determination of DNA repair protein expression and genotype in human tissues is of fundamental importance. Apurinic/apyrimidinic endonuclease 1

Strategies for Achieving Measurement Assurance for Cell Therapy Products

June 1, 2016
Author(s)
Carl G. Simon Jr., Anne L. Plant, Sumona Sarkar, John T. Elliott, Sheng Lin-Gibson
Cell therapy products (CTPs) need quantitative, validated, and robust assays to support informed decision making during their development, manufacturing, and regulation. These products, the materials involved in their production and the methods for

DNA Damage and Repair in Cancer

May 26, 2016
Author(s)
M Miral Dizdar
Oxygen- and nitrogen-derived reactive species are constantly generated in living organisms by endogenous and exogenous sources. Reactions of reactive species such as free radicals with DNA cause the formation of multiple mutagenic and cytotoxic lesions
Displaying 751 - 775 of 2355
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