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The 2017 NIST/DHS/FDA Workshop: Standards for Pathogen Detection for Biosurveillance and Clinical Applications brought together subject matter experts from the clinical and biosurveillance communities to discuss standards to support the use of next
Knowledge of the actual electrical tip shape can be used to better understand electric field gradients measured with eSPMs and to determine the suitability of various types of conducting SPM tips for electrical measurements. For co-axially shielded tips
Michael T. Stocker, Robert M. Thompson, Johannes A. Soons, Thomas B. Renegar, Xiaoyu A. Zheng
The emerging capability for measuring and analyzing the three-dimensional (3D) surface topography of forensic samples is expected to have a profound impact on firearm and toolmark identification. As forensic laboratories are working to integrate 3D
Erica L. Romsos, Margaret C. Kline, Natalia Farkas, David L. Duewer, Blaza Toman
Standard Reference Material (SRM) 2372a is intended for use in the value assignment of human genomic deoxyribonucleic acid (DNA) forensic quantitation materials. A unit of SRM 2372a consists of three well-characterized human genomic DNA materials
Cell-based technology is a fundamental pillar of modern biotechnology. Cells are used in drug discovery and validation, in the production of lifesaving medicines and high value materials, and more recently, as the therapeutic product itself, often referred
George C. Rhoderick, Michael E. Kelley, Walter R. Miller Jr., James E. Norris, Jennifer Carney, Lyn Gameson, Christina Cecelski, Cassie Goodman, Abneesh Srivastava, Joseph Hodges
There are many gas species present in the atmosphere that are associated with the earths climate. These compounds absorb and emit radiation, a process which is the fundamental cause of the greenhouse effect. The major greenhouse gases in the earths
John E. Schiel, Abigail Turner, Catherine A. Mouchahoir, Katharina S. Yandrofski, Srivalli Telikepalli, Jason King, Paul C. DeRose, Dean C. Ripple, Karen W. Phinney
The NISTmAb Reference Material (RM) 8671 is intended to be the common industry standard monoclonal antibody for pre-competitive research in harmonizing current state-of-the-art technology and designing next generation characterization technologies for
Comprehensive analysis of monoclonal antibody therapeutics involves an ever expanding cadre of technologies. Lifecycle appropriate application of current and emerging techniques requires rigorous testing followed by discussion between industry and
Cavan K. Kalonia, Frank Heinrich, Joseph E. Curtis, Sid Raman, Maria A. Miller, Steven Hudson
Passage of specific protein solutions through certain pumps, tubing, and/or filling nozzles can result in the production of unwanted subvisible protein particles (SVP). In this work, surface mediated SVP formation was investigated. Specifically, the
Paul Lemaillet, Catherine C. Cooksey, Jeeseong Hwang, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, David W. Allen
We present broadband measurements of the optical properties of tissue-mimicking solid phantoms using a single integrating sphere to measure the hemispherical reflectance and transmittance under a direct illumination at the normal incident angle. These
Cellulose nanocrystals (CNCs) are renewable, naturally derived polymeric nanomaterials that are receiving substantial attention for a wide range of potential applications. The recent availability of high quality reference materials will facilitate the
Jeanice M. Brown Thomas, David L. Duewer, Carolyn Q. Burdette, Lorna T. Sniegoski, James H. Yen
Standard Reference Material (SRM) 968f is intended for use in validating methods for determining fat soluble vitamins in human serum and plasma and value assigning in house produced control materials analyzed using those methods. A unit of SRM 968f
Lee L. Yu, Joseph Browning, Carolyn Q. Burdette, George C. Caceres, Kaitlyn Chieh, William C. Davis, MIchael Ellisor, Brittany Kassim, Stephen E. Long, Karen E. Murphy, Rabia Oflaz, Rick L. Paul, Katherine E. Sharpless, Laura J. Wood, James H. Yen, Rolf L. Zeisler
A Standard Reference Material (SRM) of seaweed, SRM 3232 Kelp Powder (Thallus laminariae) has been developed to support food and dietary supplement measurements in compliance with the Food Safety Modernization Act (FSMA) and the Dietary Supplement Health
Danyal J. Turkoglu, Huaiyu H. Chen-Mayer, Rick L. Paul, Rolf L. Zeisler
The accuracy of low-level hydrogen measurements with prompt gamma-ray activation analysis (PGAA) depends on identifying and accounting for all background H signal, including interfering signals. At the cold-neutron (CN)PGAA facility at the NIST Center for
Aaron M. Hagerstrom, Christian J. Long, Nathan D. Orloff, James C. Booth, Eric J. Marksz
Nonlinear transmission lines are interesting for two broad reasons: first, they have several direct device applications (i.e. harmonic generation, and phase shifters), and second, they provide a way to characterize nonlinear materials at mm-wave
We measured the Mueller matrix bidirectional reflectance distribution function (BRDF) of a sintered polytetrafluoroethylene (PTFE) sample over the scattering hemisphere for six incident angles (0◦ to 75◦ in 15◦ steps) and for four wavelengths (351 nm, 532
Candice Z. Ulmer, Jared Ragland, Jeremy P. Koelmel, N. Alan Heckert, Christina Jones, Timothy J. Garrett, Richard A. Yost, John Bowden
As advances in analytical separation techniques, mass spectrometry instrumentation, and data processing platforms continue to spur growth in the lipidomics field, more structurally unique lipid species are detected and annotated. The lipidomics community
A corpus of computer programs with known bugs is useful in determining the ability of tools to find bugs. This article describes the content of NIST's Software Assurance Reference Dataset (SARD), which is a publicly available collection of thousands of
Alex Olivas, Chiara C. Ferraris, Nicos Martys, Edward Garboczi, Blaza Toman, William L. George
Rheological measurements are often performed using a rotational rheometer. In this type of rheometer, the tested fluid is sheared between two surfaces, one of which acts as the rotating surface [1]. Usually, the rotational velocity is imposed and the
Ioannis Karageorgos, Elyssia S. Gallagher, Connor Galvin, David Travis Gallagher, Jeffrey W. Hudgens
Monoclonal antibody (mAb) pharmaceuticals are the fastest-growing class of therapeutics with a wide range of clinical applications. To assure their safety, these protein drugs must demonstrate highly consistent purity and stability. Key to these objectives
Craig Copeland, Craig McGray, Jon Geist, James Alexander Liddle, Robert Ilic, Samuel Stavis
We fabricate and test subresolution aperture arrays as calibration devices for optical localization microscopy. An array pitch with a relative uncertainty of approximately three parts in ten thousand enables magnification calibration with subnanometer
Srinivasa Ramisetti, Jorge O. Ona Ruales, Stephen Wise, Shantu Amin, Arun Sharma
An efficient synthesis of dibenzo[a,l]tetracene (1) and dibenzo[a,j]tetracene (2) has been developed using Diels-Alder reaction of in situ generated ortho-quinodimethane with phenanthrene-1,4-dione, followed by reductive aromatization as key steps. This
Richard Essex, Jacqueline L. Mann, Ross W. Williams, William S. Kinman, Amelie Hubert, Megan E. Bennett
A new reference material, preliminarily designated as SRM 3059, was characterized for 229Th molality (molg-1) and thorium isotope amount ratios. This SRM is intended for use in nuclear forensic analyses as an isotope dilution mass spectrometry spike. The