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Displaying 151 - 175 of 538

Best practices for benchmarking germline small-variant calls in human genomes

March 11, 2019
Author(s)
Justin M. Zook, Marc L. Salit
Standardized benchmarking approaches are required to assess the accuracy of variants called from sequence data. Although variant- calling tools and the metrics used to assess their performance continue to improve, important challenges remain. Here, as part

Impedance tuning with photoconductors to 40 GHz

January 22, 2019
Author(s)
Jasper A. Drisko, Ari D. Feldman, Franklyn J. Quinlan, James C. Booth, Nathan D. Orloff, Christian J. Long
Light has been widely used to control a variety of microwave devices, including switches, antennas, and detectors. Here, we present a photoconductive device integrated into a coplanar waveguide to tune complex impedances at microwave frequencies with

CrowdVariant: a crowdsourcing approach to curate copy number variants

January 6, 2019
Author(s)
Justin M. Zook, Marc L. Salit, Peyton Greenside, Ryan Poplin, Mark DePristo, Madeleine Cule
Copy number variants (CNVs) are an important type of genetic variation and play a causal role in many diseases. However, they are also notoriously difficult to identify accurately from next-generation sequencing (NGS) data. For larger CNVs, genotyping

Optimization of Folch, Bligh-Dyer, and Matyash Sample-to-Extraction Solvent Ratios for Mammalian Cell- and Plasma-Based Lipidomics Studies

December 11, 2018
Author(s)
John Bowden, Candice Z. Ulmer, Christina Jones, Richard A. Yost, Timothy J. Garrett
In order to investigate changes in the lipidome, analysis by ultra-high performance liquid chromatography - high resolution mass spectrometry (UHPLC-HRMS) typically requires the extraction of lipid content from sample matrices using optimized, matrix

NIST Handbook 150-8, NVLAP Acoustical Testing Services

November 19, 2018
Author(s)
Kari K. Harper
NIST Handbook 150-8 presents technical requirements and guidance for the accreditation of laboratories under the National Voluntary Laboratory Accreditation Program (NVLAP) Acoustical Testing Services program. It is intended for information and use by

Co-Operation in Publicly Funded Reference Material Production Meeting Report

October 12, 2018
Author(s)
Steven J. Choquette, Hakan Emteborg, Doris florian, Stephen Ellison, Lindsay Mackay, Pearse McCarron
The meeting was organized by the European Commission's Joint Research Centre, and held at the JRC-Geel site on 22-23 February, 2018. It was a follow-up of a similar meeting held in 2009. The objective of the meeting was to exchange information about

Innovative Approaches to Combat Healthcare-Associated Infections Using Efficacy Standards Developed Through Industry and Federal Collaboration

October 5, 2018
Author(s)
Dianne L. Poster, Carl C. Miller, Yaw S. Obeng, Michael T. Postek, Troy E. Cowan, Richard A. Martinello
Nation-wide, healthcare-associated infections (HAIs) infect one in every 25 hospital patients, account for more than 100,000 deaths and increase medical costs by around $96-147B, each year. Ultraviolet-C (UV-C) antimicrobial devices are shown to reduce the

Development of a new reversed-phase liquid chromatography and fluorescence method with multichannel selective wavelength detection for the analysis of benzo[a]pyrene and six of its isomers

September 28, 2018
Author(s)
Walter B. Wilson, Stephen A. Wise, Lane C. Sander
The baseline separation of benzo[a]pyrene in complex samples via reversed-phase liquid chromatography (RPLC) is particularly challenging due to the potential for interferences from other molecular mass 252 (MM, g/mol) polycyclic aromatic hydrocarbons (PAHs

Harmonization of LC-MS/MS protein assays

September 24, 2018
Author(s)
Alan L. Rockwood, Mark Lowenthal, Cory Bystrom
Harmonization of diagnostic test results is fundamental to the effective use of laboratory testing in the diagnosis, treatment and monitoring of disease. Formal approaches to harmonization and standardization provide a rigorous and high quality Roadmap to

Atom Probe Tomography Analysis of the Reference Zircon GJ-1: A Round-Robin Experiment

September 20, 2018
Author(s)
Ann C. Chiaramonti Debay, Paul T. Blanchard, Alexandre La Fontaine, Florent Exertier, Sandra Piazolo, Elena Belousova, Zirong Peng, Baptiste Gault, David W. Saxey, Denis Fougerouse, Steven Reddy, Julie Cairney
In recent years, atom probe tomography (APT) has been increasingly used to study minerals, and in particular Zircons. The mineral Zircon (ZrSiO4) is ideally suited for geochronology by utilising the U-Th-Pb isotope systems, and trace element compositions

Conference Report: Representing Ethnic Diversity for Precision Medicine

August 23, 2018
Author(s)
Justin M. Zook, Luke Hickey, Benedict Paten, Robert Sebra, Valerie Schneider
There is a pressing need to better represent ethnic diversity with genomic resources — and to do so in a way that maximizes utility for people working with the Genome Reference Consortium’s human reference genome. That was the theme of a panel discussion

A Reference Material for Evaluation of Cs-137 Radiochronometric Measurements

August 16, 2018
Author(s)
Kevin B. Lavelle, Richard Essex, Jeffrey T. Cessna, Kevin P. Carney, Cole R. Hexel
A new nuclear forensic reference material has been characterized as a standard for radiochronometric determination of the model purification date for 137Cs sources. The purification date of a radioactive source is a potentially diagnostic nuclear forensic

A new realization of SI for organic chemical measurement: NIST PS1 Primary Standard for quantitative NMR (Benzoic Acid)

July 30, 2018
Author(s)
Michael A. Nelson, Jason F. Waters, Blaza Toman, Brian E. Lang, Alexander R?ck, Kathrin Breitruck, Markus Obkircher, Anthony Windust, Katrice A. Lippa
Metrological traceability to common references supports the comparability of chemical measurement results produced by different analysts, at various times, and at separate places. Ideally, these references are realizations of base units of the

Certification of Standard Reference Material 1879b Respirable Cristobalite

July 27, 2018
Author(s)
David R. Black, Marcus H. Mendenhall, Pamela S. Whitfield, Craig Brown, Albert Henins, James J. Filliben, James P. Cline
The National Institute of Standards and Technology (NIST) certifies a suite of Standard Reference Materials (SRMs) to address specific aspects of the performance of X-ray powder diffraction instruments. This report describes SRM 1879b, the third generation

Subnanometer localization accuracy in widefield optical microscopy

July 11, 2018
Author(s)
Craig R. Copeland, Jon C. Geist, Craig D. McGray, Vladimir A. Aksyuk, James A. Liddle, Bojan R. Ilic, Samuel M. Stavis
The common assumption that precision is the limit of accuracy in localization microscopy and the typical absence of comprehensive calibration of optical microscopes lead to a widespread issue - overconfidence in measurement results with nanoscale
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