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Displaying 576 - 600 of 848

Fluorinated Copolymer Nanoparticles for Multimodal Imaging Applications

February 18, 2010
Author(s)
Mark M. Bailey, Christine M. Mahoney, Elodie Dempah, Jeffrey M. Davis, Matthew Becker, Supang Khondee, Eric J. Munson, Cory J. Berkland
Nanomaterials have emerged as valuable tools in biomedical imaging techniques, such as magnetic resonance imaging (MRI), fluorescence, positron emission tomography (PET), and others. Some have been designed to serve as multimodal imaging agents, combining

Microsensors in Dynamic Backgrounds: Toward Real-Time Breath Monitoring

January 15, 2010
Author(s)
Kurt D. Benkstein, Baranidharan Raman, Christopher B. Montgomery, C Martinez, Stephen Semancik
We evaluated MEMS microsensor array with chemi-resistive elements for use as a non-invasive clinical diagnostic tool to detect the presence or absence of trace amounts of disease biomarkers in simulated breath samples. The microsensor environment was

Volumetric CT in Lung Cancer: An Example for the Qualification of Imaging as a Biomarker

January 9, 2010
Author(s)
Charles D. Fenimore, Andrew Buckler, P. David Mozeley, Lawrence H. Schwartz, Nicholas Petrick, Michael McNitt-Gray, Kevin O?Donnell, Wendy Hayes, Hyun Kim, Laurence Clarke, Daniel Sullivan
The Quantitative Imaging Biomarker Alliance (QIBA) has been organized to establish a methodology whereby multiple stakeholders collaborate to test hypotheses about the technical feasibility and the medical value of imaging biomarkers. It has charged the

Gradient Nanofiber Scaffold Libraries for Rapid Screening of Cell-Material Interactions

December 1, 2009
Author(s)
Carl G. Simon Jr., Murugan Ramalingam, Marian F. Young, Vinoy Thomas
Scaffolds play a key role in tissue engineering wherein they provide structural support for cells to adhere, grow and guide them to synthesize tissue. Scaffolds made of multiple biomaterials are typically required to mimic the three-dimensional (3D)

Chemical Science and Technology Laboratory (CSTL) 2009 Annual Report

November 17, 2009
Author(s)
Willie E. May, Richard R. Cavanagh, Dianne L. Poster, Michael D. Amos
CSTL is entrusted with building, sustaining, and maximizing the chemical measurement system that is criticial to chemical technological innovation, economic competitiveness and new job growth for the benefit of the Nation.

Microfabricated multispectral MRI agents: a brief overview

September 3, 2009
Author(s)
Gary Zabow
This paper provides an introductory overview on recent top-down microfabricated, as opposed to traditional bottom-up chemically synthesized, magnetic resonance imaging (MRI) contrast agents. As a specific example of the enhanced agent functionality that

A New 26plex Autosomal STR Assay to Aid Human Identity Testing*(dagger)

September 1, 2009
Author(s)
Carolyn R. Steffen, John M. Butler, Peter Vallone
Multiplex polymerase chain reaction (PCR) has become the standard in forensic testing. Currently there are two commercial multiplex PCR amplification kits available that simultaneously amplify 16 short tandem repeat (STR) loci that include the 13 FBI

Differences in PDMS Modification Affect Laminin Deposition and Smooth Muscle Cell Response

August 16, 2009
Author(s)
Joy P. Dunkers, Hae-Jeong Lee, Marvi Matos, Lisa Pakstis, Juan M. Taboas, Steven D. Hudson, Marcus T. Cicerone
When culturing cells on flexible surfaces, it is important to consider extracellular matrix treatments that will remain on the surface under mechanical strain. Here we investigate differences in laminin surfaces that were deposited on oxidized PDMS (plasma

Protein crystal engineering of YpAC-IV using a strategy of excess charge reduction

August 5, 2009
Author(s)
David T. Gallagher, N N. Smith, Sung Kim, Howard Robinson, Prasad T. Reddy
The class IV adenylyl cyclase from Yersinia pestis has been engineered to enable crystallization at neutral pH for mechanism studies. The wild-type enzyme crystallized only at pH below 5. Based on the unliganded wild-type structure 2FJT at 1.9 Angstrom

Synthetic Lung Tumor Data Sets for Comparison of Volumetric Algorithms

July 13, 2009
Author(s)
Adele P. Peskin, Alden A. Dima, Javier Bernal, David E. Gilsinn, Karen Kafadar
The change in pulmonary nodules over time is an important indicator of malignant tumors. It is therefore important to be able to measure change in the size of tumors from computed tomography (CT) data taken at different times and on potentially different

Selective Binding of RNAse B Glycoforms by Polydopamine-immobilized Concanavalin A

June 10, 2009
Author(s)
Todd A. Morris, Alexander W. Peterson, Michael J. Tarlov
Glycoanalysis is important in the manufacture and quality control of protein therapeutics. An emerging method for glycoanalysis is the use of lectin arrays. Critical to the performance of these arrays is the immobilization of the lectin molecules

3D Imaging of Diatoms with Ion-abrasion Scanning Electron Microscopy

June 9, 2009
Author(s)
Keana C. Scott, Mark Hildebrand, Sang Kim, Dan Shi, Sriram Subramaniam
Ion-abrasion scanning electron microscopy (IASEM) takes advantage of focused ion beams to abrade thin sections from the surface of bulk specimens, coupled with SEM to image the surface of each section, enabling 3D reconstructions of subcellular

Lambda exonuclease digestion of CGG trinucleotide repeats

June 7, 2009
Author(s)
Richard Conroy, Alan Koretsky, John M. Moreland
Fragile X syndrome and other trinucleotide diseases are characterized by an elongation of a repeating DNA triplet. The ensemble-averaged lambda exonuclease digestion rate of diVerent substrates, including one with an elongated FMR1 gene containing 120 CGG

T7-Based Linear Amplification of Low Concentration mRNA Samples using Beads and Microfluidics for Global Gene Expression Measurements

April 7, 2009
Author(s)
Jason G. Kralj, Audrey Player, Hope Sedrick, Matt S. Munson, David Petersen, Samuel P. Forry, Paul Meltzer, Ernest Kawasaki, Laurie E. Locascio
We show single-cell level linear amplification of gene expression libraries immobilized on a microfluidic packed bed. This is a critical step in the Eberwine process, which is used to amplify messenger RNA (mRNA) for gene expression profiling. Microarray

Polymerization Stress Development in Dental Composites: Effect of Cavity Design Factor

March 13, 2009
Author(s)
Joseph M. Antonucci, Anthony A. Giuseppetti, Justin N. O'Donnell, Gary E. Schumacher, Drago Skrtic
Objective: To assess the effect of the cavity design factor (C-factor) on polymerization stress development (PSD) in resin composites. Methods: An experimental resin (BT resin) was prepared, which contained 2,2-bis[p-(2 hydroxy-3 -methacryloxypropoxy

Cell volume distributions reveal cell growth rates and division times

March 7, 2009
Author(s)
Michael W. Halter, John T. Elliott, Joseph B. Hubbard, Alessandro Tona, Anne L. Plant
A population of cells in culture displays a range of phenotypic responses, even when those cells are derived from a single cell and are exposed to a homogeneous environment. Phenotypic variability can have a number of sources, including the variable rates

Surface plasmon resonance imaging of cells and surface-associated fibronectin

February 26, 2009
Author(s)
Alexander W. Peterson, Michael W. Halter, Alessandro Tona, Kiran Bhadriraju, Anne L. Plant
Background A critical challenge in cell biology is quantifying the interactions of cells with their extracellular matrix (ECM) environment and the active remodeling by cells of their ECM. Fluorescence microscopy is a commonly employed technique for
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