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Material Measurement Laboratory

Patents

Searches Patent Title, Abstract, Body, Technology Type, and NIST Inventors
Displaying 1 - 25 of 55

Antibodies Targeting Marburgvirus Glycoproteins and Uses Thereof

NIST Inventors
Thomas Cleveland
Our study describes the discovery and characterization of a diverse panel of antibodies against marburgvirus GP (glycoprotein) induced by multivalent immunization and provides candidate immunotherapeutics for further study and development.
(a) Without an aptamer’s protein ligand, dARTs are transcribed to produce RNA outputs (left), while protein binding represses transcription (middle). The input and output domains are decoupled (right), enabling modular design of dARTs by swapping out the aptamer domain or customizing the output sequences. (b) dARTs serve as the protein sensing layer (left) whose outputs can be coupled with downstream circuits (middle). RNA outputs are measured via fluorescence (right).

Aptamer Regulated Transcription For In-Vitro Sensing And Transduction

NIST Inventors
Samuel Schaffter
It relates to nucleic acid transcription templates, systems, and methods for detection and measurement of molecules and biomolecules (e.g., biomarkers). Particularly, systems and methods utilize a transcription template with an aptamer domain configured to bind a molecule of interest to regulate
Schematic of double-beam modulation spectrometry using a single detector

Single-Detector Double-Path Intensity-Modulation Spectrometer

NIST Inventors
Young Jong Lee
This invention is an optical method that can minimize the noise due to system fluctuations and maximize the signal-to-noise ratio by modulating the analyte beam and the reference beam and detecting the alternating intensity difference by a signal light detector. This invention is based on a double

Curved Metallic Grating And Process For Making Same

NIST Inventors
Daniel Josell and Thomas P. Moffat
Making a curved metallic grating for matching angular divergence of incident radiation includes: providing a mandrel with a curved receiving surface; disposing a planar substrate on the curved receiving surface; applying a clamping force to the planar substrate at the planar field surface; bending
Depiction of co-transcriptional RNA strand displacement (ctRSD) design.

CTRSD Gate And Performing Co-Transcriptional Encoding

NIST Inventors
Samuel Schaffter
Scalable and programmable co-transcriptional RNA strand displacement (ctRSD) circuits. In ctRSD, circuit components isothermally self-assemble and execute programmed computations in a single transcription reaction. This is achieved through two new innovations: 1) the use of the HDV self-cleaving

Process for Making a Metallic Grating

NIST Inventors
Daniel Josell and Thomas P. Moffat
A metallic grating is formed to include a substrate; a plurality of high aspect ratio trenches disposed in the substrate such that the high aspect ratio trenches are spaced apart from one another by a field surface of the substrate; a metallic superconformal filling formed and disposed in the high

Amino Acid-Specific Binder And Selectively Identifying An Amino Acid

NIST Inventors
John P. Marino and Zvi Kelman
N-terminal amino acid binding (NAAB) reagents are a tool for parallel, high-throughput proteomics. Afluorescently-labeled NAAB allows immobilized peptides to be identified by their N-terminal residues using single-molecule fluorescent microscopy, which enables novel proteomic analysis, like

Novel Nanocomposite Phase-Change Memory Materials And Design Of The Same

NIST Inventors
Ichiro Takeuchi and Aaron Gilad Kusne
Provided herein are novel materials, such as novel phase-change memory materials providing superior characteristics, and methods of discovering/selecting such novel materials via machine learning, such as Bayesian active learning. An exemplary material provided by the inventive concept is the

Novel Nanocomposite Phase-Change Memory Materials And Design And Selection Of The Same

NIST Inventors
Ichiro Takeuchi and Aaron Gilad Kusne
Provided herein are novel materials, such as novel phase-change memory materials providing superior characteristics, and methods of discovering/selecting such novel materials via machine learning, such as Bayesian active learning. An exemplary material provided by the inventive concept is the

Methods For Electrically Charging Nanocrystals At Very Large Areas

NIST Inventors
Babak Nikoobakht
Methods are disclosed for uniformly charging nanocrystals. Using these methods large area interfaces per nanocrystal can be formed for electrically powering or operating nanocrystals. The formed metal- interfaces, including metal- semiconductor and semiconductor- semiconductor, are structurally

Dry Prelithiation Of Electrode Materials For Lithium Batteries And Supercapacitors By Controlled Dose Low Energy Implantation Of Lithium Ions

NIST Inventors
Christopher Soles , Vladimir Oleshko and Jabez J McClelland
In this disclosure, we describe a method of creating new and improved battery electrodes by doping conventional battery electrode materials with dry lithium (Li+) ions, using ion implantation techniques under vacuum. This dry "prelithiation" step will both (a) increase the amount of active Li+ in

Infrared Thermal Desorber And Performing Infrared Thermal Desorption

NIST Inventors
Matthew E Staymates and Thomas P. Forbes
An infrared thermal desorber includes a desorption housing; an infrared source receiver that receives an infrared emission source; an infrared absorber receiver that receives an infrared absorber, such that the infrared absorber receiver produces thermal energy emission; an analyte target receiver

Physiologically Stable Fluorophore And Performing Fluorescence Probing

NIST Inventors
Jeremiah Woodcock and Professor Douglas M. Fox
A physiologically stable fluorophore includes a terminal moiety including a terminal reactive site that reacts with a reactive group of a substrate; a stability linker covalently bonded to the terminal moiety; and a bridge moiety covalently bonded to the stability linker such that the stability
Lithium magneto-optical trap-based ion source (Li MOTIS).

Prelithiated Lithium Ion Battery And Making A Prelithiated Lithium Ion Battery

NIST Inventors
Christopher Soles , Vladimir Oleshko and Jabez J McClelland
The proposed method allows the injection of Li+ ions directly into the material and does not need the wet chemical or electrochemical prelithiation with liquid electrolytes and metallic lithium foils, sacrificial additives, donors, or mechanical mixing with SLMP, inducing consumption of lithium for

Metallic Grating

NIST Inventors
Daniel Josell and Thomas P. Moffat
A metallic grating includes a substrate; a plurality of high aspect ratio trenches disposed in the substrate such that the high aspect ratio trenches are spaced apart from one another by a field surface of the substrate; a metallic superconformal filling formed and disposed in the high aspect ratio

Amino Acid-specific Binder and Selectively Identifying an Amino Acid

NIST Inventors
Zvi Kelman and John P. Marino
One of the central challenges in the development of single-molecule protein sequencing technologies is achieving high- fidelity, sequential recognition and detection of specific amino acids that comprise the peptide sequence. The N-End Rule Pathway adaptor protein ClpS, natively recognizes N
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