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Aptamer Regulated Transcription For In-Vitro Sensing And Transduction
Published Patent Application Number: WO 2024/118806
Problem
Molecular biosensors that accurately measure protein concentrations without external equipment are critical for solving numerous problems in diagnostics, therapeutics, and biomanufacturing; yet modularly transducing the binding of protein antibodies, protein switches, or aptamers into a useful output remains challenging.
Invention
It relates to nucleic acid transcription templates, systems, and methods for detection and measurement of molecules and biomolecules (e.g., biomarkers). Particularly, systems and methods utilize a transcription template with an aptamer domain configured to bind a molecule of interest to regulate production of a transcribed output ribonucleic acid (RNA).
Potential Commercial Applications
Clinical diagnostics, protein sensing, biomanufacturing.
Competitive Advantage
The new method enables facile development of inexpensive and rapid biosensors for molecular detection and measurement.