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Standard Reference Materials

News and Updates

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SRM 915c Calcium Carbonate Mass Fraction Standard

January 18, 2023

This standard reference material from NIST will help calibrate procedures for calcium determinations used in clinical analysis and for routine critical...

SRM 3461: An Accurate and Precise Force Calibration Artifact

January 18, 2023

Atomic force microscopy (AFM) is a popular technique for interrogating surfaces on the micro and nano scales. The most common use for AFM is imaging; however...

A gloved hand holds a glass flask partly full of pinkish liquid, with a label in marker saying in part "NISTCHO RCB."

NIST, Partners Develop Living Reference Material for Producing Monoclonal Antibodies

January 11, 2023

Publicly available NISTCHO cell line expands the biomanufacturing and research applications of NIST’s monoclonal antibody standard, NISTmAb.

NIST Develops Yeast Material for Training First Responders on Biothreats

January 4, 2023

Researchers based the material on baker’s yeast because it is harmless and a living biological material.

What is a Standard Reference Material?

November 28, 2022

https://www.nist.gov/video/what-standard-reference-material-or-srm.

NIST Issues the First Standard Reference Material for the Quantitative Analysis of Glycans

August 3, 2022

NIST Standard Reference Material (SRM) 3655 helps biopharmaceutical manufacturers perform measurements of glycan molecules in their protein drug products...

Picture of jars containing reference materials 8256, 8257, 8258, and 8259: Wild caught and aquacultured shrimp and salmon

Four NIST Reference Materials Help Authenticate Shrimp and Salmon

July 28, 2022

Four reference materials from NIST will help the U.S. Food and Drug Administration and Customs and Border Protection agencies assess whether imported salmon and...

a picture of packaging for NIST SRM 2367JC Virus DNA Quantitative Standard

A NIST Standard for More Accurate Diagnoses of JC Virus

July 19, 2022

A new NIST Standard Reference Material supports the accurate measurement of the amount of a common but potentially dangerous virus in patients. Most of us have...

Two open glass containers hold powder, one brown and one wite, with half-filled plastic scoops next to each.

NIST Tree Nut Reference Materials Support Food Allergen Testing

June 6, 2022

Researchers from NIST have developed hazelnut and almond flour reference materials that will help ensure accurate and consistent results for industry test kits.

NIST Produces Complete Suite of Supports for Testing for Allergens in Food

April 25, 2022

With the addition of two new reference materials containing tree nuts, NIST now offers a complete set of aids for detecting allergens in food. As of 2022, the U...

NIST Supports Accurate Food Labeling with New Standard Reference Material for Fat

April 20, 2022

NIST Standard Reference Material® 2386 Avocado Powder helps food manufacturers evaluate their methods for determining the elements, vitamins, amino acids, fatty...

NIST Supports Measurements of Vitamins in Dietary Supplement Tablets

April 14, 2022

NIST Standard Reference Material ® 3289 Multivitamin Tablets will be used by testing laboratories to support the development of new analytical methods that...

An open black box with foam inserts holds plastic vials labeled SRM 2917.

NIST Collaborates With EPA to Develop a Standard to Improve Fecal Pollution Measurements in Recreational Waters

April 6, 2022

As we approach summer beach season, you may occasionally encounter a "keep out" sign indicating that the area is temporarily closed. If fecal pollution is...

Suite of NIST Reference Materials Reflects Supply Chain and Production Stages of Ginseng Supplements

January 25, 2022

Three NIST reference materials of ginseng in different forms support ginseng supplement manufacturers’ analysis of the authenticity and purity of their products...

NIST Standard Reference Material Supports Clinical Tests for Common Chronic Diseases

December 20, 2021

NIST has developed its first reference material to aid in the measurement of free fatty acids in human blood serum. Most adults who routinely monitor their...

A researcher stands on a boat reaching for a cable holding a grabber device.

NIST Releases Great Lakes Sediment Material for Measuring Organic Pollutants

November 23, 2021

People who live near the Great Lakes might go there to enjoy a swim or a boat ride. But if you’re visiting from the National Institute of Standards and...

Yellowish blades of kelp are growing under the surface of the water.

Spotlight: Harvesting What's Under the Sea for the Dietary Supplement Industry and Environmental Conservation

November 16, 2021

From domestic sludge to hydrogen in titanium, we have many different types of standard reference materials (SRMs) to ensure that industry, academia and...

New NIST Reference Material Helps Manufacturers Better Assess Their Biological Drug Products

November 15, 2021

Sugars not only provide nourishment in the food you eat but can also act as biomarkers for detecting disease. When certain types of simple sugars, such as...

NIST pH Standard Reference Material Supports One of Manufacturing’s Most Measured Properties

October 19, 2021

NIST has released a pH reference material in a uniquely stable form for calibrating the instruments used by a wide variety of manufacturers. pH is one of the...

NIST Reference Material for Hydrogen in Titanium Now in Pin Form

August 16, 2021

Hydrogen in titanium and other metal alloys can cause embrittlement, leading to fractures in manufactured parts. A popular NIST reference material for...

Two New Reference Materials Assist Supplement Makers with Measurements of Isoflavones in Kudzu

August 3, 2021

Kudzu, a member of the pea family native to East Asia and considered an invasive weed in the American South, has been used for centuries in Chinese medicine and...

Gold-colored rectangle has circles and screws of various sizes.

Spotlight: One Small Step for SRM 610 Aboard the Mars Perseverance Rover

July 20, 2021

3, 2, 1 … blast off! One of NIST’s very own standard reference materials traveled through space and landed on the Red Planet in February as part of the National...

An Aid for Instrumentation for Measuring Active Compounds in Ginseng

July 12, 2021

Ginsenosides are thought to be the active compounds in ginseng, a plant long used in Chinese medicine that is now a popular supplement and the subject of...

New NIST Reference Material Aids in Measurement of Cocoa's Active Molecules

July 1, 2021

Cocoa, the substance from which chocolate is made, is thought to have benefits to the human cardiovascular system and so has been the focus of many clinical...

Two New NIST Reference Materials for Assuring Measurements of Nutrients in Formula

June 30, 2021

To help ensure that babies and patients get all the essential amino acids and other nutrients that they need, infant and prescription adult nutritional formulas...

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