Projects/Programs

Displaying 1 - 25 of 39

Advancing live cell imaging to aid cell manufacturing

Live cell imaging shows the dynamics of single cells, and provides insight into phenotype regulation.

Biomanufacturing Initiative

Ongoing

Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The

Cell Counting for Cell Therapies

Ongoing

Cell counting (or cell enumeration) is one of the most fundamental measurements in biotechnology, from biomanufacturing to medical diagnosis to advanced therapy

Cell Line Authentication

Ongoing

Cells derived from different organisms and tissues have been established and are used in bioresearch and for the production of complex biological products. The

Chinese hamster ovary (CHO) cell line authentication

Ongoing

The misidentification of cell lines has been a problem in the scientific community for the past 50 years. Methods are now in place to genotype human cell lines

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing

As ‘omics moves into industrial and commercial applications, there is a need for quality and process control to ensure safety and efficacy of products and

Development of a Collagen Fibril Reference Material for Reproducible Cell Response

Ongoing

An important determinant of cellular response to drugs and toxins is the chemical and physical nature of the extracellular matrix (ECM) to which cells are

Development of the NIST Prototype Advanced Biometrology Laboratory

Ongoing

Blog detailing the renovation, retrofitting, and assembly of new type of metrology laboratory

ERCC 2.0: Developing a New Suite of RNA Controls

Ongoing

In July 2014, ERCC members initiated the ERCC 2.0 effort to develop an updated suite of RNA controls that will keep pace with advances in RNA measurement

External RNA Controls Consortium

Completed

RNA Spike-in Controls for Gene Expression

Fluid Suspensions and Emulsions

Ongoing

The purpose of this project is to create rheological measurement methods and tools, focused on using minimal fluid volumes, to measure local flow dynamics and

Glycan Standard Reference Materials

Ongoing

HDX-MS for Biopharmaceutical Analysis

Ongoing

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins

Live Cell Imaging of Induced Pluripotent Stem Cell Populations

Ongoing

Induced pluripotent stem cell (iPSC) populations are complex, dynamic and heterogeneous. Individual cells within a population are constantly changing, while

MML researchers develop reference materials and methods for quantitative phase microscopy with off-the-shelf products

Measurement Assurance for Quantitative Cell Imaging by Optical Microscopy

Ongoing

A micromechanical bulk acoustic resonator that uses phononic crystal tethers to achieve a quality factor approaching the fundamental dissipation limit (fxQ can be as large as 1.2 x 1013 Hz)

Micro- and Nanoelectromechanical Systems

Ongoing

Microelectromechanical systems (MEMS) are integrated devices with critical applications in sensing, timing, signal processing, and biomedical diagnostics, and

Monoclonal Antibody Mass Spectral Libraries

Ongoing

The National Institute of Standards and Technology is developing a mass spectral library of all identifiable components derived from the digestion of monoclonal

NIST Flow Cytometry Standards Consortium 

Ongoing

Flow cytometry is used to analyze individual cells to understand the proteins, nucleic acids and other biomolecules they have or produce, and to analyze groups

NIST Genome Editing Consortium

Ongoing

The National Institute of Standards and Technology Genome Editing Consortium addresses the measurements and standards needed to increase confidence and lower

NIST Monoclonal Antibody Reference Material 8671

Ongoing

NOW AVAILABLE The NIST monoclonal antibody (NISTmAb) reference material, RM 8671, is intended for use in evaluating the performance of methods for determining

NIST PS1 Primary Standard for quantitative NMR (Benzoic Acid)

Ongoing

The "first-of-its-kind" in an entirely new class of reference material, NIST PS1 Primary Standard for quantitative NMR (Benzoic Acid) is now available! The PS

NISTCHO

Ongoing

An open-access, living reference material for biomanufacturing innovation and collaboration

Optical/electrical particle measurement system

Ongoing

The sizing and counting of subvisible particles in the size range 2 μm to 100 μm is an essential component of product quality assurance in therapeutic protein

Pathogen Detection and Identification in the Clinical Setting: The Next Generation of Analyses

Ongoing

NIST and FDA are co-developing DNA-based materials for mixed microbial detection. Our annual workshop brings together private and public interests to discuss

Photonic Dosimetry

Ongoing

As part of the NIST on a Chip program, the Photonic Dosimetry project is developing in-situ sub-micrometer ionizing-radiation dosimetry and calorimetry leading

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