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Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The
Cell counting (or cell enumeration) is one of the most fundamental measurements in biotechnology, from biomanufacturing to medical diagnosis to advanced therapy
Cells derived from different organisms and tissues have been established and are used in bioresearch and for the production of complex biological products. The
The misidentification of cell lines has been a problem in the scientific community for the past 50 years. Methods are now in place to genotype human cell lines
As ‘omics moves into industrial and commercial applications, there is a need for quality and process control to ensure safety and efficacy of products and
An important determinant of cellular response to drugs and toxins is the chemical and physical nature of the extracellular matrix (ECM) to which cells are
In July 2014, ERCC members initiated the ERCC 2.0 effort to develop an updated suite of RNA controls that will keep pace with advances in RNA measurement
The purpose of this project is to create rheological measurement methods and tools, focused on using minimal fluid volumes, to measure local flow dynamics and
This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins
Induced pluripotent stem cell (iPSC) populations are complex, dynamic and heterogeneous. Individual cells within a population are constantly changing, while
Microelectromechanical systems (MEMS) are integrated devices with critical applications in sensing, timing, signal processing, and biomedical diagnostics, and
The National Institute of Standards and Technology is developing a mass spectral library of all identifiable components derived from the digestion of monoclonal
Flow cytometry is used to analyze individual cells to understand the proteins, nucleic acids and other biomolecules they have or produce, and to analyze groups
The National Institute of Standards and Technology Genome Editing Consortium addresses the measurements and standards needed to increase confidence and lower
NOW AVAILABLE The NIST monoclonal antibody (NISTmAb) reference material, RM 8671, is intended for use in evaluating the performance of methods for determining
The "first-of-its-kind" in an entirely new class of reference material, NIST PS1 Primary Standard for quantitative NMR (Benzoic Acid) is now available! The PS
The sizing and counting of subvisible particles in the size range 2 μm to 100 μm is an essential component of product quality assurance in therapeutic protein
NIST and FDA are co-developing DNA-based materials for mixed microbial detection. Our annual workshop brings together private and public interests to discuss
As part of the NIST on a Chip program, the Photonic Dosimetry project is developing in-situ sub-micrometer ionizing-radiation dosimetry and calorimetry leading