Projects/Programs

Displaying 1 - 25 of 32

Autonomous Systems for Materials Research and Metrology: Accelerating Discovery and Democratizing Science

Ongoing

We are developing novel machine learning algorithms and incorporating them into closed-loop autonomous systems to accelerate knowledge capture in the lab and in

Building Measurement Confidence for Cell Characterization

Ongoing

Cells are being used in drug discovery, therapeutics development, biomedical research, and biotechnological and medical applications. However, the measurement

Chinese hamster ovary (CHO) cell line authentication

Ongoing

The misidentification of cell lines has been a problem in the scientific community for the past 50 years. Methods are now in place to genotype human cell lines

Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program

Ongoing

NIST is developing a portal to enable researchers to mine high-quality proteomic data from phylogenetically diverse species, to identify advantageous biological

Comparative Serum Proteomics Project

Ongoing

Initially the Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program will generate proteomic data from sera from 25 different species that

DARPA Friend or Foe (FoF) -- Independent Verification and Validation (IV&V)

Ongoing

The development of new platforms for characterization of complex microbial samples are hampered by lack of reproducibility and comparability across different

Development of the NIST Prototype Advanced Biometrology Laboratory

Ongoing

Blog detailing the renovation, retrofitting, and assembly of new type of metrology laboratory

Engineering of G Protein-Coupled Receptors

Ongoing

We work to engineer novel function in GPCRs using a microbial platform. This enables rapid, and multi-objective engineering, to precisely characterize and tune

Fluorescence Microscopy Benchmarking: Overview

Ongoing

Originally used to prove the existence of biological cells, the microscope has long been recognized for its important role in biological research. Surprisingly

Label-free imaging of cells and their extracellular matrix by SPR imaging

Ongoing

Large-Scale Genotype-Phenotype Landscape Measurements for Precision Engineering of Living Measurement Systems

Ongoing

All living things measure their environment, make decisions, and respond. Systematic re-engineering of these living measurement and control systems has the

Live Cell Imaging of Induced Pluripotent Stem Cell Populations

Ongoing

Induced pluripotent stem cell (iPSC) populations are complex, dynamic and heterogeneous. Individual cells within a population are constantly changing, while

MML researchers develop reference materials and methods for quantitative phase microscopy with off-the-shelf products

Measurement Assurance for Quantitative Cell Imaging by Optical Microscopy

Ongoing

Measurements for minimal cells

Ongoing

Technologies to manipulate biological systems have far outpaced our ability to design the function of those systems in a predictable way. This is, in part, a

Methods to determine the evolutionary stability of engineered biological function

Ongoing

Evolution poses unique challenges to engineering in living organisms. The successful implementation and development of a sustainable bioeconomy will require

Metrology For Cell-Free Expression Systems

Ongoing

The Cellular Engineering Group works to provide metrology for rapid, successful translation of safe, effective bioproducts based on cell-free expression systems

Next Generation Metrics for Cell-Based Therapies and Regenerative Medicines

Ongoing

NIST/EDRN Cancer Biomarker Collaboration

Ongoing

NIST supports the National Cancer Institute (NCI) Early Detection Research Network (EDRN) as a Biomarker Reference Laboratory by efficiently validating the

NIST Flow Cytometry Lab

Ongoing

Our experienced staff leverage the latest cytometry technologies to develop innovative flow cytometry measurement solutions, standards, and reference materials

NIST Flow Cytometry Standards Consortium 

Ongoing

Flow cytometry is used to analyze individual cells to understand the proteins, nucleic acids and other biomolecules they have or produce, and to analyze groups

NISTCHO

Ongoing

An open-access, living reference material for biomanufacturing innovation and collaboration

Optical Coherence Tomography for Label-Free Measurement of Cell Viability in Hydrogel Scaffolds

Ongoing

In the field of tissue engineering, 3D scaffolds and cells are often combined to yield constructs that are used as therapeutics to repair or restore tissue

TOP: Image of fluorescent reference material on microscope. BOTTOM: Charting of microscope control parameters.

Performance Benchmarking and Intensity Calibration of a Widefield Fluorescence Microscope

Ongoing

We have made available a method to characterize a fluorescence microscope's performance by benchmarking the detection threshold, saturation and linear dynamic

Prototype Cell Assay Measurement Platform (P-CAMP)

Ongoing

A major focus at NIST is to apply measurement assurance tools to improve the performance of any cell-based assay to achieve a high-end, high-quality documentary

Quantitative, Traceable Determination of Cell Viability Using Absorbance Microscopy

Ongoing

Most cell-based protocols require knowledge of the number of live and dead cell populations. The current methods, however, lack traceability, which is

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