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We are developing novel machine learning algorithms and incorporating them into closed-loop autonomous systems to accelerate knowledge capture in the lab and in
Cells are being used in drug discovery, therapeutics development, biomedical research, and biotechnological and medical applications. However, the measurement
The misidentification of cell lines has been a problem in the scientific community for the past 50 years. Methods are now in place to genotype human cell lines
NIST is developing a portal to enable researchers to mine high-quality proteomic data from phylogenetically diverse species, to identify advantageous biological
Initially the Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program will generate proteomic data from sera from 25 different species that
The development of new platforms for characterization of complex microbial samples are hampered by lack of reproducibility and comparability across different
We work to engineer novel function in GPCRs using a microbial platform. This enables rapid, and multi-objective engineering, to precisely characterize and tune
Originally used to prove the existence of biological cells, the microscope has long been recognized for its important role in biological research. Surprisingly
All living things measure their environment, make decisions, and respond. Systematic re-engineering of these living measurement and control systems has the
Induced pluripotent stem cell (iPSC) populations are complex, dynamic and heterogeneous. Individual cells within a population are constantly changing, while
Technologies to manipulate biological systems have far outpaced our ability to design the function of those systems in a predictable way. This is, in part, a
Evolution poses unique challenges to engineering in living organisms. The successful implementation and development of a sustainable bioeconomy will require
The Cellular Engineering Group works to provide metrology for rapid, successful translation of safe, effective bioproducts based on cell-free expression systems
NIST supports the National Cancer Institute (NCI) Early Detection Research Network (EDRN) as a Biomarker Reference Laboratory by efficiently validating the
Flow cytometry is used to analyze individual cells to understand the proteins, nucleic acids and other biomolecules they have or produce, and to analyze groups
In the field of tissue engineering, 3D scaffolds and cells are often combined to yield constructs that are used as therapeutics to repair or restore tissue
We have made available a method to characterize a fluorescence microscope's performance by benchmarking the detection threshold, saturation and linear dynamic
A major focus at NIST is to apply measurement assurance tools to improve the performance of any cell-based assay to achieve a high-end, high-quality documentary