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Bioscience

Projects/Programs

Keyword

Organizational Unit

NIST Urine Albumin Standardization Program

Ongoing

The NIST Urine Albumin Standardization Program is focused on the development of a measurement procedure and reference materials to support an international

NIST23: Updates to the NIST Tandem and Electron Ionization Spectral Libraries

Ongoing

The latest release of the NIST Mass Spectral Library, which includes the NIST Tandem Mass Spectral Library and NIST/EPA/NIH Mass Spectral Library and NIST GC

NISTCHO

Ongoing

An open-access, living reference material for biomanufacturing innovation and collaboration

Ontologies and Interoperability in Evolutionary Comparative Analysis

Ongoing

Many computer-based inferences in contemporary biology are comparative and would benefit from the rigorous and flexible approach of evolutionary comparative

Optical/electrical particle measurement system

Ongoing

The sizing and counting of subvisible particles in the size range 2 μm to 100 μm is an essential component of product quality assurance in therapeutic protein

Optofluidic Cytometry

Ongoing

This NIST-wide collaborative project aims to improve biotechnology and medical diagnostics by increasing the resolution and precision of measurements of cells

3D Orientation Imaging

Ongoing

Microscopic molecular alignment occurs ubiquitously in various synthetic and natural materials, determining their biological, chemical, and mechanical

Orthogonal Measurements

Ongoing

Reliable measurements of quality attributes of medical products are required for quality control and verification of safety and efficacy. To reduce (i) the risk

Pathogen Detection and Identification: The Next Generation of Analyses

Ongoing

NIST and FDA are co-developing DNA-based materials for mixed microbial detection. Our annual workshop brings together private and public interests to discuss

Peptide Mass Spectral Libraries

Ongoing

The National Institute of Standards and Technology is developing a peptide mass spectral library as an extension of the NIST/EPA/NIH Mass Spectral Library

TOP: Image of fluorescent reference material on microscope. BOTTOM: Charting of microscope control parameters.

Performance Benchmarking and Intensity Calibration of a Widefield Fluorescence Microscope

Ongoing

We have made available a method to characterize a fluorescence microscope's performance by benchmarking the detection threshold, saturation and linear dynamic

Performance Metrics for Proteomics

Ongoing

In collaboration with the National Cancer Institute's Clinical Proteomic Technologies for Cancer (CPTC), NIST researchers are developing specific and

Point-of-Care Pharmaceutical Manufacturing & Precision Medicine

Ongoing

The COVID-19 pandemic highlighted the need for an agile and resilient pharmaceutical manufacturing and distribution framework. Advancements in manufacturing

Polyelectrolyte Solutions and Gels

Ongoing

We engage with leaders in the pharmaceutical, dental, and personal care research sectors that rely on water soluble polymers (polyelectrolytes) to develop new

Materials Extrusion Additive Manufacturing

Polymer Additive Manufacturing and Rheology

Ongoing

The manufacture of polymeric materials from their raw form into their final useful product occurs under highly non-equilibrium conditions where temperature and

Protection Against Ionizing Radiation in Extreme Radiation-resistant Microorganisms

Ongoing

We measured the levels of modified DNA bases following ү-irradiation of the halophilic archaeon, Halobacterium sp. str. NRC-1. In this first study to quantify

Protein Preservation

Ongoing

Our goal is to address critical measurement issues that exist regarding chemical and physical stability of biomacromolecules (proteins and DNA) in hydrophilic

Protein rheology measurements

Ongoing

Therapeutic protein solutions are highly concentrated during manufacturing purification processes and in finished dosage. At such concentrations, the fluid

Protocol for Preparing Fibrillar Collagen Matrices on Untreated Polystyrene Labware (Petri)*: A Potential Reference Extracellular Matrix With Robust and Reproducible Cell Responses

Ongoing

Background: Collagen type 1 is the most prevalent extracellular protein in connective tissue, and is part of the family of collagens that are fibril forming

Bioscience

Projects/Programs

NIST Urine Albumin Standardization Program

NIST23: Updates to the NIST Tandem and Electron Ionization Spectral Libraries

NISTCHO

Ontologies and Interoperability in Evolutionary Comparative Analysis

Optical/electrical particle measurement system

Optofluidic Cytometry

3D Orientation Imaging

Orthogonal Measurements

Pathogen Detection and Identification: The Next Generation of Analyses

Peptide Mass Spectral Libraries

Performance Benchmarking and Intensity Calibration of a Widefield Fluorescence Microscope

Performance Metrics for Proteomics

Point-of-Care Pharmaceutical Manufacturing & Precision Medicine

Polyelectrolyte Solutions and Gels

Polymer Additive Manufacturing and Rheology

Protection Against Ionizing Radiation in Extreme Radiation-resistant Microorganisms

Protein Preservation

Protein rheology measurements

Protocol for Preparing Fibrillar Collagen Matrices on Untreated Polystyrene Labware (Petri)*: A Potential Reference Extracellular Matrix With Robust and Reproducible Cell Responses

Prototype Cell Assay Measurement Platform (P-CAMP)

Quantification of Cells with Specific Phenotypic Characteristics

Quantitative, Cell-based Immunofluorescence Assays

Quantitative Flow Cytometry Measurements

Quantitative MRI

Quantitative, Traceable Determination of Cell Viability Using Absorbance Microscopy

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---Chemical Sciences Division
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---Quantum Measurement Division
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