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Material Measurement Laboratory

Projects/Programs

Displaying 351 - 375 of 575

NCAL: Quantifying Crystallographic Texture and Phase Fraction

Ongoing
Predicting the deformation and force response of a polycrystalline material with the level of accuracy needed by today’s manufacturers requires knowledge of the aggregate deformation and force response of all the grains in the material. Polycrystalline materials will respond differently depending on
Tension compresion fixturing with upper and lower loadcells and grips and lateral anti-buckling guides with pneumatic actuators

NCAL: Tension-Compression Testing

Ongoing
The inability to predict the mechanical behavior of new automotive alloys during forming has generated strong demand in industry for more advanced material models and test methods necessary to calibrate them. Industry is particularly interested in modeling the behavior of advanced sheet metals
Word cloud with word Method as the prominent word

New Chemical Measurement Methods

Ongoing
The Biochemical and Exposure Science Group (BESG) located at the Hollings Marine Laboratory is focused on advancing measurement techniques to effectively detect compounds of emerging concern. The BESG has a long history of developing accurate and precise analytical methods for emerging organic
Photograph of an automobile at an emissions testing station, with testing equipment and probe positioned at the car tailpipe.

New Gas Standard Reference Materials to Support the Automotive Industry

Completed
NIST currently supports AIGER members by maintaining reasonable inventories of required gas SRMs that consist of dilute mixtures of key pollutants such as carbon dioxide, carbon monoxide, hydrocarbons, and nitric oxide. Newer vehicles produce lower levels of these pollutants because their engines
Graphical Depiction of the Microwave Induced Combustion Process for S Determination in Coal SRMs

New Methods for Measurement of Sulfur in Fossil Fuels

Ongoing
NIST has a long history of developing high accuracy analytical methods and SRM materials for trace elements in fossil fuels. NIST has applied the microwave induced combustion methodology in combination with isotope dilution analysis for sulfur determinations, representing the first-reported

Next Generation Metrics for Cell-Based Therapies and Regenerative Medicines

Ongoing
The science of human health and disease often includes studies of cells, the smallest unit of biological complexity. Microscopic imaging is an important tool in these studies and can provide morphological and molecular information. Molecular microscopic data is most often collected in a static mode
Photo of fuel platform burning on the sea water

NIST Assists in Marine-Related Disaster Response

Ongoing
NIST and the Biospecimen Science Group continue to collaborate with NOAA Fisheries, other federal and state agencies, and non-profit organizations to provide the ability to accurately assess exposure of marine animals to environmental stressors and provide a resource for retrospective analysis of
autonomous vehicles on a road

NIST and Autonomous Vehicles

Ongoing
Why Autonomous Vehicles? Autonomous vehicles are projected to influence key aspects of everyday life including transportation, goods delivery, manufacturing, public safety, and security. In addition, the autonomous vehicle sector is a vastly inter-disciplinary field with subject areas including
NIST Biorepository Freezers

The NIST Biorepository

Ongoing
The NBSB was established in 1979 at NIST in Gaithersburg, MD with a pilot project archiving human liver samples associated with collections through the Environmental Protection Agency (EPA). New collaborations and banking projects were established including the National Oceanic and Atmospheric

The NIST Chemistry Webbook

Ongoing
Intended Impact It is part of NIST's mission to distribute Standard Reference Data to scientists, engineers, educators, and the general public. The NIST Chemistry WebBook is intended to help fulfill NIST's mission by distributing such data over the Internet. Objective Develop a web site

NIST Combinatorial Methods Center (NCMC)

Completed
Established in 2002, the NCMC combines pioneering research and customer engagement to foster wide-spread adaptation of combinatorial and high-throughput methodologies. NCMC research addresses key challenges faced by polymer researchers who want to employ combi. In particular, the NCMC creates new
Conceptual Art of Gas Molecules Adsorbed in a Zeolite Adsorbent

NIST Data Resources for Adsorption

Ongoing
NIST/ARPA-e Database of Novel and Emerging Adsorbent Materials A centralized resource for the scientific community to find and compare single- and multi-component adsorption isotherms reported in the literature. The database sorts data according to adsorbent material, adsorbate species

NIST/EDRN Cancer Biomarker Collaboration

Completed
Our lab is one of the EDRN Biomarker Reference Laboratories working with the EDRN discovery labs to improve the quality of the measurements done on new cancer biomarkers for early detection of cancer and for cancer risk. TECHNICAL APPROACH Evaluate current assays used for detection of cancer
Flow Cytometry Consortium

NIST Flow Cytometry Standards Consortium 

Ongoing
Advances in cell and gene-based therapeutics as well as other regenerative medicine products have increased the need for high quality, robust, and validated measurements for cell characterization. Flow cytometry, including imaging cytometry, has emerged as an important platform due to its ability to
Montage of photographs depicting eggs, almonds, grain, milk, strawberries, fish, peanuts, and soybeans.

NIST Food Protein Allergen Program

Ongoing
Food allergen management is an increasingly important economic and public health concern; therefore, accurate and reliable allergen measurements are a crucial component of the management pathway. Traditional methods for food allergen detection are based on immunoassay techniques and are linked to a
photo collage of meats, cheese, eggs, fish, and shellfish

NIST Food Safety Program

Ongoing
The Food Safety Program at the National Institute of Standards and Technology (NIST) provides advanced analytical chemistry and quantitative biology to ensure that food is free of contaminants and allergens and is authentic, promoting U.S. manufacturers’ participation in domestic and foreign markets

NIST Genome Editing Consortium: Working Group 2 - Data & Metadata

Ongoing
Develop a metadata schema for genome editing experiments Develop a way of curating and entry that is low burden for user Release control data with linked metadata PROGRESS Phase1 metadata entries and templates completed In process of compiling and testing use cases, user interfaces, and
Genome editing technologies

NIST Genome Editing Consortium

Ongoing
Targeted genome editing , a method used to alter the DNA of living cells at desired locations, is poised to revolutionize science and medicine. To fight diseases, novel genome edited therapeutics, including those for use in regenerative medicine and infectious diseases, are being developed. Many

NIST Genome Editing Consortium: Working Group 1 - Specificity Measurements

Ongoing
Genome editing technologies are able to produce DNA sequence changes of a variety of sizes and at a variety of frequencies in a population of edited cells. Having increased confidence in reliably detecting the sequences generated by a genome editing process was a need area identified. Project 1

NIST Genome Editing Lexicon

Ongoing
The definitions are worded with the intention that additional context may be added with supplementary language when they are used. It is also recognized that genome editing is a rapidly evolving biotechnology and additional terms and definitions will be needed as genome editing technologies mature

NIST Genome Editing Program

Ongoing
For genome editing systems to reach their full potential in research and commercial products, new measurement tools, capabilities, and standards must be developed to efficiently implement and assess the performance of these editing technologies, as well as to evaluate the utility of resulting
HER2 SRM Unit and Individual Components

NIST HER2 Genomic DNA Standard Reference Material, SRM® 2373

Ongoing
The amplification of the gene for HER2 occurs in approximately 20 to 25% of breast cancers. The accurate measurement of this biomarker is important for the proper treatment with anti-HER2 therapeutics. Clinical laboratories are beginning to utilize accurate and sensitive diagnostic tests based on
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