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Search Publications by: Sheng Lin-Gibson (Fed)

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Displaying 26 - 50 of 132

Effects of nanoparticle size and charge on interactions with self-assembled collagen

March 1, 2014
Author(s)
Dongbo Wang, Jing (. Ye, Steven Hudson, Keana Scott, Sheng Lin-Gibson
Recent insights into bone formation have suggested that the critical first step to the biomineralization process is the integration of small (nanometer dimension) mineral clusters into collagen fibers. Such behavior is of intrinsic interest for the areas

Airbrushed Nanofiber Scaffolds Support Bone Marrow Stromal Cell Differentiation

November 1, 2013
Author(s)
Carl G. Simon Jr., Wojtek J. Tutak, Sumona Sarkar, Tanya M. Farooque, Jyotsnendu J. Giri, Dongbo Wang, Sheng Lin-Gibson, Joachim Kohn, Durgadas Bolikal
Nanofiber scaffolds are effective for tissue engineering since they emulate the fibrous nanostructure of native extracellular matrix (ECM). Although electrospinning has been the most common approach for fabricating nanofiber scaffolds, airbrushing

Effects of dual antibacterial agents MDPB and nano-silver in primer on microcosm biofilm, cytotoxicity and dentin bond properties

February 1, 2013
Author(s)
Ke Zhang, Lei Cheng, Satoshi Imazato, Joseph M. Antonucci, Nancy Lin, Sheng Lin-Gibson, Yuxing Bai, Hockin H. Xu
Objectives: Secondary caries at restoration margins is the main reason for restoration failure. Antibacterial bonding agents are promising to inhibit biofilm acids at the tooth-restoration interfaces. The objective of this study was to investigate the

Effect of Polymer Degree of Conversion on Streptococcus mutans Biofilms

October 5, 2012
Author(s)
Alison M. Kraigsley, Kathy Tang, John A. Howarter, Katrice Lippa, Sheng Lin-Gibson, Nancy Lin
The effects of key material properties of polymeric composite restorations on cariogenic oral biofilms are needed to provide insight into the materials' role in recurrent caries. The objective of this study was to quantify the effects of degree of

Antibacterial nanocomposites containing amorphous calcium phosphate and silver nanoparticles with different filler levels

May 7, 2012
Author(s)
Lei Cheng, Michael D. Weir, Hockin H. Xu, Joseph M. Antonucci, Nancy Lin, Sheng Lin-Gibson, Sarah M. Xu, Xuedong Zhou
A dental composite containing amorphous calcium phosphate nanoparticles (NACP) was developed that released high levels of calcium (Ca) and phosphate (PO4) ions and possessed acid neutralization capability. There has been little study on incorporation of

Positively-charged Dimethacrylates to Reduce Bacterial Attachment

March 30, 2012
Author(s)
Nancy J. Lin, Joseph M. Antonucci, Diana N. Zeiger, Sheng Lin-Gibson, Kathy Tang
The widespread incidence of recurrent tooth decay (caries) highlights the need for improved dental restorative materials. Caries are most frequently caused by acid-producing bacterial biofilms. One approach for developing biomaterials with reduced

Antibacterial amorphous calcium phosphate nanocomposite with quaternary ammonium salt and silver nanoparticles

February 2, 2012
Author(s)
Nancy Lin, Lei Cheng, Michael D. Weir, Hockin H. Xu, Joseph M. Antonucci, Alison M. Kraigsley, Sheng Lin-Gibson, Xuedong Zhou
Objectives. Calcium and phosphate ion-releasing resin composites are promising for remineralization; however, so far there has been no report on imparting a potent antibacterial capability to these composites. The objectives of this study were to

Synthesis and characterization of antimicrobial dimethacrylates containing quaternary ammonium functionalities for dental and biomedical applications

October 27, 2011
Author(s)
Joseph M. Antonucci, Diana N. Zeiger, Sheng Lin-Gibson, Bruce O. Fowler, Nancy J. Lin
The widespread incidence of recurrent caries has resulted in the need for improved dental restorative materials, including effective antibacterial, polymeric dental materials. Compounds with quaternary ammonium groups are known to reduce bacterial growth

Analyses of a Cantilever-Beam Based Instrument for Evaluating the Development of Polymerization Stresses

August 9, 2011
Author(s)
Martin Chiang, Anthony A. Giuseppetti, Joy Dunkers, Jing Qian, Sheng Lin-Gibson, Gary E. Schumacher, Joseph M. Antonucci
Analytical and finite element analyses have been performed on a cantilever-beam based methodology (tensometer) for evaluating the development of stresses as the concomitant of constrained polymerization shrinkage. A guideline for designing a tensometer

Combinatorial and High-throughput Screening of Biomaterials

June 6, 2011
Author(s)
Carl Simon Jr., Sheng Lin-Gibson
The review describes recent advances in utilizing combinatorial and high-throughput methods to better understand cell-material interactions, in terms of cell toxicity, adhesion, morphology, migration, proliferation and differentiation, particularly

Mechanics behind 4-D interferometric measurement of biofilm mediated tooth decay

May 16, 2011
Author(s)
Michael S. Waters, Bin (. Yang, Nancy J. Lin, Sheng Lin-Gibson
Evaluating the efficacy of dental materials to protect human teeth requires the capacity to measure tooth accurately and precisely decay. Current practices for determining tooth decay are destructive, qualitative to lowly quantitative, and/or measure bulk

Imaging Cells in Polymer Scaffolds by X-Ray Microcomputed Tomography

May 11, 2011
Author(s)
Shauna M. Dorsey, Sheng Lin-Gibson, Carl Simon Jr.
We have investigated the ability of X-ray microcomputed tomography (CT) to make quantitative, three-dimensional (3D) measurements of cell adhesion and proliferation in polymeric tissue engineering scaffolds. The most common method for examining cells in

Modulus-Driven Differentiation of Marrow Stromal Cells in 3D Is Independent of Cytoskeletal Integrity

April 11, 2011
Author(s)
Carl G. Simon Jr., Kaushik Chatterjee, Sapun Parekh, Sheng Lin-Gibson, Nicole M. Moore, Marcus T. Cicerone, Marian F. Young
Cell functions such as proliferation, migration, and differentiation are key physiological processes that are influenced by the physiochemical extracellular environment. We report on the effect of three-dimensional (3D) scaffold modulus on human bone

In situ Formation of Silver Nanoparticles in Photocrosslinking Polymers

February 2, 2011
Author(s)
Yajun Cheng, Diana N. Zeiger, John A. Howarter, Xinran Zhang, Nancy Lin, Joseph M. Antonucci, Sheng Lin-Gibson
Nanocomposites of difunctional methacrylate polymer/silver nanoparticles have been synthesized by coupling photoinitiated free radical polymerization with in situ silver ion reduction. A polymerizable methacrylate bearing a secondary amino function group

Controlled in situ Nanocavitation in Polymeric Materials

January 18, 2011
Author(s)
Yajun Cheng, Joseph M. Antonucci, Steven Hudson, Nancy Lin, Xinran Zhang, Sheng Lin-Gibson
A new strategy to produce polymer-inorganic composites with ultra low volume shrinkage has been developed. Small amount of cavitation agent, acetone dicarboxylic acid (ADCA), was introduced into acrylate-glass composites and decomposed in situ to carbon

Effects of Polymeric Nanogratings on Cell Orientation

December 30, 2010
Author(s)
Nancy J. Lin, Sheng Lin-Gibson, Jirun Sun, Yifu Ding
Surface topography is known to play a critical role in the biological response to materials, with surface features on the order of both microns and nanometers altering cell response, including morphology, adhesion, cytoskeletal orientation, and gene

Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation

November 1, 2010
Author(s)
Carl G. Simon Jr., Sapun Parekh, Marcus T. Cicerone, Sheng Lin-Gibson, Kaushik Chatterjee, Marian F. Young
There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human bone