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Publications

Search Publications by

Vincent A. Hackley (Fed)

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Displaying 1 - 25 of 147

Preparation, Characterization, and Biological Activity of Stability-Enhanced Polyethyleneimine-Conjugated Gold Nanoparticles (Au-PEI@NIST) for Biological Application

September 16, 2021
Author(s)
Tae Joon Cho, Vincent A. Hackley, Feng Yi, David A. LaVan, Vytas Reipa, Alessandro Tona, Bryant C. Nelson, Christopher Sims, Natalia Farkas
In this special publication, we report on a modified synthetic process that results in a stable suspension of Au-PEI nanoparticles, Au-PEI@NIST. Synthesized materials were characterized using an orthogonal approach that included dynamic light scattering

Detection, counting and characterization of nanoplastics in marine bioindicators: a proof of principle study

April 15, 2021
Author(s)
Jeremie Parot, Andrea Valsesia, Jessica Ponti, Dora Mehn, Rita Marino, Daniela Melillo, Samantha Facchetti, Shinichiro Muramoto, R. Michael Verkouteren, Vincent A. Hackley, Pascal Colpo
Plastic particulates in the environment pose an increasing concern for regulatory bodies due to their potential risk to higher organisms (including humans) as they enter the food chain. Nanoplastics (pNP) (defined here as smaller than 1 µm) are

Certification of Standard Reference Material(R) 1992 / ERM(R)-FD305 Zeta Potential - Colloidal Silica (Nominal Mass Fraction 0.15 %)

November 24, 2020
Author(s)
Yannic Ramaye, Vikram Kestens, J. Charoud-Got, S. Mazoua, G. Auclair, Tae Joon Cho, Blaza Toman, Vincent A. Hackley, T. Linsinger
This report describes the production of SRM 1992/ERM-FD305, silica particles suspended in a borate buffer, certified for electrophoretic mobility and zeta potential by electrophoretic light scattering (ELS). This material was produced following ISO 17034

Certification of Standard Reference Material(R) 1993 / ERM(R)-FD306 Zeta Potential - Colloidal Silica (Nominal Mass Fraction 2.2 %)

November 24, 2020
Author(s)
Yannic Ramaye, Vikram Kestens, J. Charoud-Got, S. Mazoua, G. Auclair, Tae Joon Cho, Blaza Toman, Vincent A. Hackley, T. Linsinger
This report describes the production of SRM 1993/ERM-FD306, silica particles suspended in a borate buffer, certified for electrophoretic mobility and zeta potential by electrophoretic light scattering (ELS). This material was produced following ISO 17034

Parallel multi-parameter study of PEI-functionalized gold nanoparticle synthesis for bio- medical applications: Part 2. Elucidating the role of surface chemistry and polymer structure on performance

November 10, 2020
Author(s)
Tae Joon Cho, Justin M. Gorham, John M. Pettibone, Jingyu Liu, Jiaojie Tan, Vincent A. Hackley
Despite the breadth and quality of published work in this area, it remains unclear how the specific properties of polyethyleneimine (PEI) and the methods utilized to conjugate it to gold nanoparticles (AuNPs) impact the final product morphology and

The certification of electrophoretic mobility/zeta potential of silica particles in aqueous solution: ERM-FD305/SRM 1992

October 27, 2020
Author(s)
Y. Ramaye, V. Kestens, J. Charoud-Got, S. Mazoua, G. Auclair, Tae Joon Cho, Blaza Toman, Vincent A. Hackley, T. Linsinger
This report describes the production of ERM-FD305/SRM 1992, silica nanoparticles suspended in a borate buffer, certified for electrophoretic mobility and zeta potential measurements by electrophoretic light scattering (ELS). This material was produced

The certification of electrophoretic mobility/zeta potential of silica particles in aqueous solution: ERM-FD306/SRM 1993

October 23, 2020
Author(s)
Yannic Ramaye, Vikram Kestens, J. Charoud-Got, S. Mazoua, G. Auclair, Tae Joon Cho, Blaza Toman, Vincent A. Hackley, T. Linsinger
This report describes the production of ERM-FD306/SRM 1993, silica nanoparticles suspended in a borate buffer, certified for electrophoretic mobility and zeta potential measurements. This material was produced following ISO Guide 17034:2016 and is

Quantifying protein aggregation kinetics using electrospray differential mobility analysis

January 5, 2020
Author(s)
Kaleb J. Duelge, Jeremie Parot, Vincent A. Hackley, Michael R. Zachariah
Protein aggregation is a significant concern in bioprocessing and end use applications. Here the thermal aggregation kinetics of bovine serum albumin (BSA) and α-chymotrypsinogen A (α- chymo) were measured over a range of concentrations and temperatures by

Sizing up the Next Generation of Nanomedicines

December 11, 2019
Author(s)
Jeffrey D. Clogston, Vincent A. Hackley, Adriele Prina-Mello, Sanyogitta Puri, Silvia Sonzini, Patrick Lim Soo
During the past two decades the field of nanomedicines has experienced significant progress. To date, over sixty nanoparticle (NP) formulations have been approved in the US and EU while many others are in clinical or preclinical development, indicating a

Characterization of Size and Aggregation for CNC Dispersions Separated by Asymmetrical-flow Field-flow Fractionation

December 9, 2019
Author(s)
Jeremie Parot, Arnab K. Mukherjee, Martin Couillard, Maohui Chen, Shan Zou, Vincent A. Hackley, Linda Johnston
Cellulose nanocrystals derived from various types of cellulose biomass have significant potential for applications that take advantage of their availability from renewable natural resources and their high mechanical strength, biocompatibility and ease of

Parallel multi-parameter study of PEI-functionalized gold nanoparticle synthesis for bio-medical applications: Part 1. A critical assessment of methodology, properties and stability

August 20, 2019
Author(s)
Tae Joon Cho, Justin M. Gorham, John M. Pettibone, Jingyu Liu, Jiaojie Tan, Vincent A. Hackley
Cationic polyethyleneimine (PEI) conjugated gold nanoparticles (AuNPs) that are chemically and physically stable under physiological conditions are an ideal candidate for certain bio-medical applications, in particular DNA transfection. However, the

Discriminated properties of PEI functionalized gold nanoparticles (Au-PEIs) predetermined by synthetic routes of ligand exchange and reduction processes: Paths and Fates

June 17, 2019
Author(s)
Tae Joon Cho, John M. Pettibone, Vincent A. Hackley
Polyethyleneimine (PEI) functionalized AuNPs (Au-PEIs) are have potent as positively charged gold nanoparticles (AuNPs) for nano-medicinal applications, due to their cationic surfaces that promote cellular uptake and gene transfection. 1-6 1-6 1-61-6 Au

Bridging communities in the field of nanomedicine

April 30, 2019
Author(s)
Blanka Halamoda-Kenzaoui, Simon Baconnier, Thierry Bastogne, Didier Bazile, Patrick Boisseau, Gerrit Borchard, Sven E. Borgos, Luigi Calzolai, Karin Cederbrant, Gabriella di Felice, Tiziana Di Francesco, Marina Dobrovolskaia, Rog?rio Gaspar, Bel?n Gracia, Vincent A. Hackley, Lada Leyens, Neill Liptrott, Margriet Park, Anil Patri, Gert Roebben, Matthias Roesslein, Ren? Th?rmer, Patricia Urb?n L?pez, Val?rie Zuang, Susanne Bremer-Hoffmann
The workshop "Bridging communities in the field of nanomedicine" was hosted by the European Commission Joint Research Centre on 27-28 September 2017. It gathered experts from regulatory bodies, research institutions and industry to discuss the main

Fast quantification of nanorod geometry by DMA-spICP-MS

February 18, 2019
Author(s)
Jiaojie Tan, Yong Yang, Hind El Hadri, Mingdong M. Li, Vincent A. Hackley, Michael R. Zachariah
A fast, quantitative method for determining the geometries of nanorods (i.e., length and dimeter) is described, based on hyphenation of differential mobility analysis (DMA) with single particle inductively coupled plasma mass spectrometry (spICP-MS). Seven

Approaches for the Quantitative Analysis of Oxidation State in Cerium Oxide Nanomaterials

September 21, 2018
Author(s)
Christopher M. Sims, Russell A. Maier, Aaron C. Johnston-Peck, Justin M. Gorham, Vincent A. Hackley, Bryant C. Nelson
Cerium oxide nanomaterials (nanoceria, CNMs) are receiving increased attention from the research community due to their unique chemical properties, most prominent of which is their ability to alternate between the Ce3+ and Ce4+ oxidation states. While many

Agglomeration of Escherichia coli with positively charged nanoparticles can lead to artifacts in a standard Caenorhabditis elegans toxicity assay

April 19, 2018
Author(s)
Shannon Hanna, Antonio Montoro Bustos, Alexander W. Peterson, Vytas Reipa, Leona D. Scanlan, Sanem Hosbas Coskun, Tae Joon Cho, Monique Johnson, Vincent A. Hackley, Bryant C. Nelson, Michael R. Winchester, John T. Elliott, Elijah Petersen
The increased use and incorporation of engineered nanoparticles (ENPs) in consumer products requires a robust assessment of their potential environmental implications. However, a lack of standardized methods for nanotoxicity testing has yielded results