Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Introduction of nanoscale positive controls for nanotoxicology: A new aspect of utilization of stability-enhanced Gold-Polyethyleneimine conjugates (Au-PEIs)

Published

Author(s)

Tae Joon Cho, Vincent A. Hackley, Vytas Reipa, Alessandro Tona, Christopher Sims, Natalia Farkas

Abstract

Polyethyleneimine (PEI) conjugated gold nanoparticles (Au-PEIs) have potential use as positively charged gold nanoparticles (AuNPs) for nanomedical applications, due to their cationic surface that promotes cellular uptake and gene transfection. We report on a stable suspension of Au-PEI@NIST, prepared by an optimized synthetic process. The physico-chemical properties of Au-PEI@NIST were characterized using multiple analytical instruments. The nanoparticles in this study demonstrated excellent colloidal stability avoiding particle agglomeration and/or aggregation in various aqueous environments, which is very critical to become effective materials in nanomedicine. Most importantly, the cytotoxicity of Au-PEI@NIST was investigated using a variety of cell lines and showed a common dose proportional toxicity, suggesting potential for use as a universal nanoscale positive control in nanotoxicity studies.
Proceedings Title
Introduction of nanoscale positive controls for nanotoxicology: A new aspect of utilization of stability-enhanced Gold-Polyethyleneimine conjugates (Au-PEIs)
Conference Dates
July 4-8, 2022
Conference Location
Palma de Mallorca, ES
Conference Title
The 22nd IEEE International Conference on Nanotechnology (IEEE-NANO 2022)

Keywords

gold nanoparticles, polyethyleneimine, colloidal stability, nanotoxicity, nanoscale positive control

Citation

Cho, T. , Hackley, V. , Reipa, V. , Tona, A. , Sims, C. and Farkas, N. (2022), Introduction of nanoscale positive controls for nanotoxicology: A new aspect of utilization of stability-enhanced Gold-Polyethyleneimine conjugates (Au-PEIs), Introduction of nanoscale positive controls for nanotoxicology: A new aspect of utilization of stability-enhanced Gold-Polyethyleneimine conjugates (Au-PEIs), Palma de Mallorca, ES, [online], https://doi.org/10.1109/NANO54668.2022.9928706, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=934177 (Accessed April 19, 2024)
Created November 8, 2022, Updated March 7, 2023