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Search Publications by: Michael Gaitan (Assoc)

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Displaying 26 - 50 of 164

Nanoslinky: DNA Entropophoresis Down a Nanofluidic Staircase

October 4, 2010
Author(s)
Elizabeth A. Strychalski, Laurie E. Locascio, Samuel M. Stavis, Michael Gaitan
Almost all nanofluidic devices for biopolymer analysis have been limited by one or two confining structural dimen-sions or the application of external forces for biopolymer manipulation, which has restricted the scope of related lab-on-a-chip technology

Microfluidic Based Contactless DielectrophoreticDevice: Modeling and Analysis

September 1, 2010
Author(s)
Saugandhika Minnikanti, Darwin Reyes-Hernandez, Ruben C. Aguilar, Joseph Pancrazio, Michael Gaitan, Nathalia Peixoto
While there have been many attempts at patterning cells onto substrates, a reliable method for trapping cell clusters and forming cell arrays in a predefined geometry remains to be demonstrated. We intend to develop a multielectrode array platform to

Separation and Metrology of Nanoparticles by Nanofluidic Size Exclusion

August 11, 2010
Author(s)
Samuel M. Stavis, Jon C. Geist, Michael Gaitan
A nanofluidic approach to the separation and metrology of nanoparticles is demonstrated. Advantages of this approach include nanometer-scale resolution, nanometer-scale to submicrometer-scale range, mitigation of hydrodynamic and diffusional limitations to

Quantum Dot FRET Sensor for Enzymatic Activity in Microfluidic Device

June 22, 2010
Author(s)
Georgeta Crivat, Sandra M. Da Silva, Darwin Reyes-Hernandez, Samuel Forry, Laurie E. Locascio, Michael Gaitan, Nitsa Rosenzweig, Zeev Rosenzweig
This paper describes the development of new fluorescence resonance energy transfer (FRET)-based quantum dot probes for proteolytic activity. The CdSe/ZnS quantum dots are incorporated into a thin polymeric film, which is prepared by layer-by-layer

Microfluidic Directed Self-Assembly of Liposome-Hydrogel Hybrid Nanoparticles

April 29, 2010
Author(s)
Jennifer S. Hong, Samuel M. Stavis, Silvia H. De Paoli Lacerda, Laurie E. Locascio, Srinivasa R. Raghavan, Michael Gaitan
We present a microfluidic method to direct the self-assembly of liposome-hydrogel hybrid nanoparticles. Our approach yields nanoparticle size distributions that are highly monodisperse and precisely controlled across a broad range relevant to the targeted

Microfluidic Mixing and the Formation of Nanoscale Lipid Vesicles

April 27, 2010
Author(s)
Andreas Jahn, Samuel M. Stavis, Jennifer S. Hong, Wyatt N. Vreeland, Don L. DeVoe, Michael Gaitan
We investigate the formation of unilamellar lipid vesicles (liposomes) with diameters of tens of nanometers by microfluidic hydrodynamic focusing (MHF). Our study includes liposome synthesis experiments and numerical modeling of our microfluidic

Accurate optical analysis of single molecule entrapment in nanoscale vesicles

January 1, 2010
Author(s)
Joseph E. Reiner, Andreas Jahn, Samuel M. Stavis, Michael J. Culbertson, Wyatt N. Vreeland, Daniel L. Burden, Jon C. Geist, Michael Gaitan
We present a non-destructive method to characterize low analyte concentrations in nanometer scale lipid vesicle formulations. Our method is based on the application of fluorescence fluctuation analysis (FFA) and multi-angle laser light scattering (MALLS)

Nanofluidic Structures with Complex Three Dimensional Surfaces

March 31, 2009
Author(s)
Samuel M. Stavis, Elizabeth Strychalski, Michael Gaitan
A fabrication process was developed to construct nanofluidic devices with complex three dimensional (3D) topographies. A single layer of grayscale photolithography enabled arbitrary and simultaneous control of numerous nanoscale etch depths in a fused

Electrical Manipulation of Gold Nanoparticles for Microfluidic Applications

October 16, 2008
Author(s)
Darwin R. Reyes-Hernandez, Geraldine I. Mijares, Kimberly A. Briggman, Jon C. Geist, Michael Gaitan
An electrical method to trap and release gold nanoparticles to and from the surface of alkanethiol-modified gold electrodes is presented. When a positive bias versus a Ag/AgCl reference electrode was applied to gold electrodes, negatively-charged gold