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Displaying 476 - 500 of 861

An instrumented bioreactor for mechanical stimulation and real-time, nondestructive evaluation of engineered cartilage tissue

June 1, 2012
Author(s)
Jenni R. Popp, Justine Roberts, Douglas V. Gallagher, Kristi S. Anseth, Stephanie Bryant, Timothy P. Quinn
Mechanical stimulation is essential for chondrocyte metabolism and cartilage matrix deposition. In vitro, mechanical stimulation is accomplished via culture in a bioreactor. Traditional methods for evaluating the developing tissue are destructive, time

On the need for an international effort to capture, share and use crystallisation screening data (failure and success)

June 1, 2012
Author(s)
David Gallagher, Janet Newman, Evan E. Bolton, Jochen M?Dieckmann, Vincent J. Fazio, David Lovell, Joseph R. Luft, Thomas S. Peat, David Ratcliffe, Roger A. Sayle, Edward H. Snell, Kerry Taylor, Pascal Vallotton, Sameer Velankar, Frank V. Delft
Crystallisation of biological macromolecules is seen by most structural biologists as a necessary evil, a means to the end, which is knowledge about a macromolecular structure. Crystallization remains largely a trial-and-error process, with extensive

Developing digital tissue phantoms for hyperspectral imaging of ischemic wounds

May 18, 2012
Author(s)
David W. Allen, Jeeseong Hwang, Maritoni A. Litorja, Joseph P. Rice
Biomedical optical imaging has the potential to achieve high spatial resolution and high functional sensitivity for non-invasive assessment of ischemic wounds. However, clinical acceptance of many optical imaging devices is hampered by poor reproducibility

Optimization of Imaging Polymer Based Scaffolds Using X-Ray Microcomputed Tomography

May 15, 2012
Author(s)
David E. Morris, Melissa L. Mather, Carl Simon Jr., John A. Crowe
The performance of polymer based scaffolds used in regenerative medicine is linked to their structural properties and as such strategies for structural characterization of scaffolds have been developed. X-ray microscopic computed tomography (X-ray micro CT

Designing Microarrays Phantoms for Hyperspectral Imaging Validation

May 9, 2012
Author(s)
Matthew L. Clarke, Ji Y. Lee, Daniel V. Samarov, David W. Allen, Maritoni A. Litorja, Ralph Nossal, Jeeseong Hwang
The simple design of custom-tailored microarrays for the characterization of hyperspectral imaging systems and analysis methods for biologically relevant samples. Individual and mixtures of dyes were printed on microscope slides and imaged by a

Gas-Foamed Scaffold Gradients for Combinatorial Screening in 3D

May 1, 2012
Author(s)
Carl G. Simon Jr., Kaushik Chatterjee, Alison M. Kraigsley, Joachim Kohn, Durgadas Bolikal
Current methods for screening cell-material interactions typically utilize two-dimensional (2D) culture format where cells are cultured on flat surfaces. However, there is a need for combinatorial and high-throughput screening methods to systematically

Osteoblast Response to Serum Protein Adsorption in 3D Polymer Scaffolds

May 1, 2012
Author(s)
Carl G. Simon Jr., Girish Kumar, Kaushik Chatterjee, Stevephen Hung
Protein adsorption is known to direct biological response to biomaterials and is important in determining cellular response in tissue scaffolds. In this study we investigated the effect of adsorbed serum proteins on cell attachment and proliferation in

Uncertainty in RECIST as a measure of volume for lung nodules and liver malignoma

April 27, 2012
Author(s)
Zachary H. Levine, Adam L. Pintar, John G. Hagedorn, Charles D. Fenimore, Claus P. Heussel
The authors investigate the extent to which the RESPONSE Evaluation Criateria in Solid Tumors (RECIST) can predict tumor volumes and changes in volume using clinical data. The data presented are a reanalysis of data acquired in other studies, including the

Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance

April 26, 2012
Author(s)
Bryant C. Nelson, Bryce J. Marquis, Anna L. Seager, Ume K. Shah, Jane M. Mikhail, Shareen H. Doak, George E. Johnson, Paul L. Carmichael, Sharon J. Scott, Andrew D. Scott, Gareth J. Jenkins
Oxidative stress contributes to many disease aetiologies including ageing, neurodegeneration, and cancer, partly through DNA damage induction (genotoxicity). Understanding the interactions of free radicals with DNA is fundamental to discern the mutation

Three-dimensional Shape Metrology for Tissue Engineering

April 21, 2012
Author(s)
Joy P. Dunkers, Antonio M. Possolo, Thomas V. Lafarge, Beatriz Pateiro-Lopez, Jeffrey Coles, Carl G. Simon Jr.
The physical and chemical properties of a tissue scaffold influences cell response and therefore the success of the resulting tissue construct. Scaffold structure from nanometers to millimeters can direct cell behavior, from viability to proliferation to

Dielectrophoretic Cell Capture on Polyester Membranes

April 2, 2012
Author(s)
Conni Hanke, Petra S. Dittrich, Darwin Reyes-Hernandez
A new system for dielectrophoretic cell capture on porous polyester (PET) membranes is presented. Conventional photolithographic techniques were used to fabricate gold microelectrodes on a PET membrane. We characterized these electrodes to proof that there

Positively-charged Dimethacrylates to Reduce Bacterial Attachment

March 30, 2012
Author(s)
Nancy J. Lin, Joseph M. Antonucci, Diana N. Zeiger, Sheng Lin-Gibson, Kathy Tang
The widespread incidence of recurrent tooth decay (caries) highlights the need for improved dental restorative materials. Caries are most frequently caused by acid-producing bacterial biofilms. One approach for developing biomaterials with reduced

Tumor Necrosis Factor Interaction with Gold Nanoparticles

March 14, 2012
Author(s)
De-Hao D. Tsai, Sherrie R. Elzey, Frank W. DelRio, Robert I. MacCuspie, Suvajyoti S. Guha, Michael R. Zachariah, Athena M. Keene, Jeffrey D. Clogston, Vincent A. Hackley
We report on a systematic investigation of molecular conjugation of tumor necrosis factor protein-α (TNF) onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spectroscopic

Freeform Fabricated Scaffolds with Roughened Struts that Enhance both Stem Cell Proliferation and Differentiation by Controlling Cell Shape

March 1, 2012
Author(s)
Girish Kumar, Carl G. Simon Jr., Michael S. Waters, Tanya M. Farooque, Marian F. Young
We demonstrate that imparting freeform fabricated (FFF) scaffolds with surface roughness on their struts enhances osteogenic differentiation of primary human bone marrow stromal cells (hBMSCs) by controlling cell shape. Previous work showed that hBMSCs

Predictive Gold Nanocluster Formation Controlled by Metal-Ligand Complexes

January 9, 2012
Author(s)
John M. Pettibone, Jeffrey W. Hudgens
The formation of ligand-protected transition metal nanoclusters in size-selective syntheses is driven by the inherent properties of the protecting ligands. We have previously reported the selective, monodisperse product formation of phosphine protected Au
Displaying 476 - 500 of 861
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