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Uncertainty in RECIST as a measure of volume for lung nodules and liver malignoma



Zachary H. Levine, Adam L. Pintar, John G. Hagedorn, Charles D. Fenimore, Claus P. Heussel


The authors investigate the extent to which the RESPONSE Evaluation Criateria in Solid Tumors (RECIST) can predict tumor volumes and changes in volume using clinical data. The data presented are a reanalysis of data acquired in other studies, including the public database from the Lung Image Database Consortium (LID) and from a study of liver malignoma. The principal conclusion is that a given RECIST diameter predicts volume to a factor of 17 or 10 respectively with 95 % confidence and that changes in volume are predicted only a little better: to within a factor of 8 for the liver data. Additionally, we show the RECIST threshold of 10 mm to follow a nodule corresponds to a transition zone of a factor fo 10 in volume for the nodules in the LIDC database.
Medical Physics


RECIST , LIDC , nodule , volumetrics


Levine, Z. , Pintar, A. , Hagedorn, J. , Fenimore, C. and Heussel, C. (2012), Uncertainty in RECIST as a measure of volume for lung nodules and liver malignoma, Medical Physics, [online], (Accessed April 14, 2024)
Created April 27, 2012, Updated February 19, 2017