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Displaying 30226 - 30250 of 143806

Structural Changes and Aggregation Mechanisms for Anti-Streptavidin IgG1 at Elevated Concentration

December 10, 2015
Author(s)
Gregory V. Barnett, Wei Qi, Samiul Amin, E. Neil Lewis, Vladimir I. Razinkov, Bruce A. Kerwin, Yun Liu, Christopher J. Roberts
Non-native protein aggregation may occur during manufacturing and storage of protein therapeutics, and this may decrease drug efficacy or jeopardize patient safety. From a regulatory perspective, changes in higher-order structure due to aggregation are of

Trusted Geolocation in the Cloud: Proof of Concept Implementation

December 10, 2015
Author(s)
Michael Bartock, Murugiah Souppaya, Raghuram Yeluri, Uttam Shetty, James Greene, Steve Orrin, Hemma Prafullchandra, John McLeese, Jason Mills, Daniel Carayiannis, Tarik Williams, Karen Scarfone
This publication explains selected security challenges involving Infrastructure as a Service (IaaS) cloud computing technologies and geolocation. It then describes a proof of concept implementation that was designed to address those challenges. The

High-Resolution Imaging and Spectroscopy at High Pressure: A Novel Liquid Cell for the Transmission Electron Microscope

December 9, 2015
Author(s)
Mihaela M. Tanase, Jonathan P. Winterstein, Renu Sharma, Vladimir A. Aksyuk, Glenn E. Holland, James A. Liddle
We demonstrate quantitative core-loss electron energy-loss spectroscopy of iron oxide nanoparticles and imaging resolution of Ag nanoparticles in liquid down to 0.24 nm, in both transmission and scanning-transmission modes, in a novel, monolithic liquid

Magnetic Fluctuations Driven Insulator-to-Metal Transition in Ca(Ir 1-x Ru x )O 3

December 9, 2015
Author(s)
J. Gunasekera, Leland Harriger, A. Dahal, T. Heitmann, G. Vignale, D. K. Singh
Magnetic fluctuations in transition metal oxides are a subject of intensive research because of the key role they are expected to play in the transition from the Mott insulator to the unconventional metallic phase of these materials, and also as drivers of
Displaying 30226 - 30250 of 143806
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