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Martin Wissink, Kirk Goldenberger, Luke Ferguson, Yuxuan Zhang, Hassina Bilheux, Jacob LaManna, David Jacobson, Michael Kass, Charles Finney, Jonathan Willocks
Neutron imaging offers deep penetration through many high-Z materials while also having high sensitivity to certain low-Z isotopes such as 1H, 6Li, and 10B. This unique combination of properties has made neutron imaging an attractive tool for a wide range
Stuart R. Castillo, Brett W. Rickeard, Mitchell DiPasquale, Michael H. Nguyen, Aislyn Lewis-Laurent, Milka Doktorova, Batuhan Kav, Markus S. Miettinen, Michihiro Nagao, Elizabeth Kelley, Drew Marquardt
Pancratistatin (PST) is a natural antiviral alkaloid that has demonstrated specificity towards cancerous cells and explicitly targets the mitochondria. PST initiates apoptosis while leaving healthy, noncancerous cells unscathed. However, the manner by
Small-angle neutron scattering (SANS) has been a beneficial tool for studying the structure of biological macromolecules in solution for several decades. Continued improvements in sample preparation techniques, including deuterium labeling, neutron
Lipid bilayers are a key component of cell membranes and play a crucial role for life and in bio-nanotechnology. As a result, controlling their physicochemical properties holds the promise of effective therapeutic strategies. Ionic liquids (ILs) – a vast
Ohsung Oh, Youngju Kim, Daeseung Kim, Daniel Hussey, Seung Wook Lee
Grating interferometry is a promising technique to obtain differential phase contrast images with illumination source of low intrinsic transverse coherence. However, retrieving the phase contrast image from the differential phase contrast image is
D. Sweeney, Susan T. Krueger, Kakali Sen, John Hackett
Nanolipoprotein particles known as nanodiscs (NDs) have emerged as versatile and powerful tools for the stabilization of mem-brane proteins permitting a plethora of structural and biophysical studies. Part of their allure is their flexibility to
Peng Luo, Yanqin Zhai, Peter Falus, Victoria Garcia Sakai, Monika Hartl, Maiko Kofu, Kenji Nakajima, Antonio Faraone, Y. Z
Employing high-intensity wide-angle neutron spin-echo spectroscopy, we measured the coherent intermediate scattering function of the prototypical ionic glass former Ca 0.4K 0.6(NO 3) 1.4 in the equilibrium and supercooled liquid state from 383 to 519 K
Erkan Senses, Christopher Kitchens, Antonio Faraone
The addition of nanoparticles to a polymer matrix can in certain cases induce a reduction in viscosity, with respect to the pure matrix, in the resulting composites. This counterintuitive phenomenon cannot be explained using the most common rheological
Amy Y. Xu, Nicholas J. Clark, Joseph Pollastrini, Maribel Espinoza, Hyo-Jin Kim, Sekhar Kanapuram, Bruce Kerwin, Michael J. Treuheit, Susan T. Krueger, Arnold McAuley, Joseph E. Curtis
Igor K. Mkam Tsengam, Marzhana Omarova, Elizabeth Kelley, Alon V. McCormick, Geoffrey D. Bothun, Srinivasa R. Raghavan, Vijay T. John
The phospholipid lecithin (L) and the nonionic surfactant Tween 80 (T) are used together in various contexts, including in drug delivery and oil spill remediation. There is hence a need to elucidate the nanostructures in L/T mixtures, which is the focus of
L. Anovitz, P. Huestis, N. Rampal, A. G. Stack, J. A. LaVerne, X. Zhang, G. K. Schenter, J. Chun, B. A. Legg, L. Liu, Markus Bleuel, Cedric V. Gagnon, D. F. Mildner
Youngju Kim, Daeseung Kim, Jongyul Kim, Daniel Hussey, Mona Mirzaei, Dmitri Pushin, Charles W. Clark, Seung Lee
We describe an inverse Talbot-Lau neutron grating interferometer that provides an extended autocorrelation length range for quantitative dark-field imaging. To our knowledge, this is the first report of a Talbot-Lau neutron grating interferometer (nTLI)
David Hoogerheide, Philip A. Gurnev, Tatiana Rostovtseva, Sergey M. Bezrukov
Voltage-activated complexation is the process by which a transmembrane potential drives complex formation between a membrane-embedded channel and a soluble or membrane-peripheral target protein. Metabolite and calcium flux across the mitochondrial outer
Shipra Malik, Vikas Kumar, Chung-Hao Liu, Kuo-Chih Shih, Susan T. Krueger, Mu-Ping Neih, Raman Bahal
Peptide nucleic acids (PNAs) are nucleic acid analogs with superior hybridization properties and enzymatic stability than deoxyribonucleic acid (DNA). In addition to gene targeting applications, PNAs have garnered significant attention as bio-polymer due
David Hoogerheide, Joseph Dura, Brian B. Maranville, Charles F. Majkrzak
Liquid cells are an increasingly common sample environment for neutron reflectometry experiments and are critical for measuring the properties of materials at solid/liquid interfaces. Background scattering determines the maximum useful scattering vector
Ryan Klein, Rafael Balderas-Xicohtencatl, Jan Petter Maehlen, Terrence J. Udovic, Craig Brown, Robert Delaplane, Yongqiang Cheng, Roman Denys, Anibal Ramirez Cuesta, Volodymyr Yartys
Intermetallic metal hydrides are critical materials for hydrogen storage applications, however, metal hydrides with greater storage capacities are still needed. Within metal hydrides, the volumetric storage capacities are limited by the number of hydrogen
Cheol Jeong, Ryan Franklin, Karen J. Edler, Kenno Vanommeslaeghe, Joseph E. Curtis
Lipid nanodiscs can be used to solubilize functional membrane proteins (MPs) in nativelike environments. Thus, they are promising reagents that have been proven useful to characterize MPs. Both protein and non-protein molecular belts have shown promise to
Yanqin Zhai, Peng Luo, Jackson Waller, Jeffrey L. Self, Leland Harriger, Y. Z., Antonio Faraone
The dynamics of molecular associates in methanol/water mixtures was investigated using quasielastic neutron scattering. By measuring the signal from four methanol/water samples differing only by their isotopic composition, the relative motion of the water
Adam Brooks, Daniel Hussey, Kyungmin Ham, David Jacobson, Ingo Manke, Nikolay Kardjilov, Leslie G. Butler
We survey several neutron imaging and diffraction methods for non-destructive testing and evaluation of intact, commercial lithium-ion batteries. Specifically, far-field interferometry was explored as an option to probe a wide range of autocorrelation
Abigail Fenton, Renxuan Xie, Melissa Aplan, Youngmin Lee, Michael Gill, Ryan Fair, Fabian Kempe, Michael Sommer, Chad R. Snyder, Enrique Gomez, Ralph Colby
The relationship between Kuhn length lk, Kuhn monomer volume v0, and plateau modulus GN0 , initially proposed by Graessley and Edwards for flexible polymers, and extended by Everaers, has a large gap in experimental data between the flexible and stiff
Elizabeth Kelley, Emily Blick, Vivek Prabhu, Paul Butler, Michihiro Nagao
Lipid vesicles are widely used as models for cell membranes, hosts for membrane protein studies, and containers for hydrophilic molecules. The vesicle solutions in these applications are usually prepared at a specific lipid concentration; however, because
Neutron scattering methods were employed to study the microscopic structure and dynamics of Bio Crude Oils (BCOs) and their lignin fractions. The structure of the carbonaceous aggregates was investigated using Small Angle Neutron Scattering to reveal a