U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Standards

Reference materials

Search Publications

Search Title, Abstract, Conference, Citation, Keyword or Author
  • Published Date
Displaying 1 - 25 of 1012

Certification of Standard Reference Material(R) 956e Electrolytes in Frozen Human Serum

April 2, 2025
Author(s)
Lee Yu, Steven Christopher, Regina Easley, Monique Johnson, Dennis Leber, Thomas Vetter, Jason Waters, Charles Barber, Karen Murphy, Laura Wood, Stephen Chin, Murli Narayan, Alexander Rhodes, Michael Nash
The National Institute of Standards and Technology (NIST) Standard Reference Material® (SRM®) 956e Electrolytes in Frozen Human Serum is intended for use in the calibration and validation of procedures and methods employed in clinical analysis for the

Certification of Standard Reference Material(R) 965c Glucose in Frozen Human Serum

March 13, 2025
Author(s)
Amanda Bayless, William Davis, Elena Wood, Abraham Kuri Cruz, Johanna Camara, Blaza Toman, Komal Dahya, Katherine Earl, Chui Tse, Uliana Danilenko, Hubert Vesper
Standard Reference Material (SRM) 965c Glucose in Frozen Human Serum is intended for use in validating methods for the determination of glucose in human serum and plasma. A unit of SRM 965c consists of three ampoules each of four materials: Level 1, Level

Commutability Assessment of New Standard Reference Materials (SRMs) for Determining Serum Total 25-Hydroxyvitamin D using Ligand Binding and Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS) Assays

January 10, 2025
Author(s)
Stephen Wise, Etienne Cavalier, Pierre LUKAS, Stephanie Peeters, caroline Le Goff, Laura Briggs, Emma Williams, Ekaterina Mineva, Christine Pfeiffer, Hubert Vesper, Christian Popp, Christian Beckert, Jan Schultess, Kevin Wang, Carole Tourneur, Camille Pease, Dominik Osterritter, Ralf Fischer, Ben Saida, Chao Dou, Satoshi Kojima, Hope Weiler, Agnieszka Bielecki, Heather Pham, Alexandra Bennett, Shawn You, Amit Ghoshal, Chistian Vogl, James Freeman, Neil Parker, Samantha Pagliaro, Jennifer Cheek, Jie Li, Hisao Tsukamoto, Karen Galvin, Kevin Cashman, Hsuan-Chieh Liao, Andrew Norbert Hoofnagle, Jeffery Budd, Adam Kuszak, Ashley Boggs-Russell, Carolyn Burdette, Grace Hahm, Federica Nalin, Johanna Camara
Commutability is where the measurement response for a reference material (RM) is the same as for an individual patient sample with the same concentration of analyte measured using two or more measurement systems. Assessment of commutability is essential

Small variant benchmark from a complete assembly of X and Y chromosomes

January 8, 2025
Author(s)
Justin Wagner, Nathanael Olson, Jennifer McDaniel, Lindsay Harris, Chunlin Xiao, Fritz Sedlazeck, Kishwar Shafin, Andrew Carroll, Justin Zook
The sex chromosomes contain complex, important genes impacting medical phenotypes, but differ from the autosomes in their ploidy and large repetitive regions. To enable technology developers along with research and clinical laboratories to evaluate variant

Recommendations for assessing commutability of a replacement batch of a secondary calibrator certified reference material

December 16, 2024
Author(s)
Liesbet Deprez, Jesper Johansen, Thomas Keller, Jeffrey Budd, Neil Greenberg, Cas Weykamp, Sverre Sandberg, MAURO PANTEGHINI, Ferruccio Ceriotti, Elizabeth Barczak, Robert Rej, Pernille Kjeilen Fauskanger, Finlay MacKenzie, Johanna Camara, Alicia Lyle, W. Greg Miller, VINCENT DELATOUR
Commutable secondary certified reference materials (CRMs) play an essential role in the calibration hierarchy of many in-vitro diagnostic measurement procedures used in the medical laboratory. Therefore, sustainable availability of these CRMs is crucial to

Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards

October 3, 2024
Author(s)
Tracey Schock, Christina Jones, Federico Torta, Nils Hoffmann, Bo Burla, Irina Alecu, Makoto Arita, Takeshi Bamba, Steffany A.L. Bennett, Justine BERTRAND-MICHEL, Britta Brugger, Monica Molina, Maria Dolores Camacho Munoz, Antonio Checa, Michael Chen, Michelle Cinel, Benoit COLSCH, Cristina Coman, Bebiana Da Costa Sousa, Alex Dickens, Maria Maria, Finnur Freyr Eiriksson, Hector Gallart-Ayala, Mohan Ghorasaini, Martin Giera, Xue Guan, Mark Haid, Thomas Hankemeier, Amy Harms, Marcus Horing, Michal Holcapek, Thorsten Hornemann, Chunxiu Hu, Andreas Hulsmeier, Julijana Ivanisevic, Harald Kofeler, Sin Man Lam, Jong Cheol Lee, Gerhard Liebisch, Andrea F Lopez-Clavijo, Malena Manzi, Peter Meikle, Maria Monge, Sneha Muralidharan, Anna Nicolaou, Valerie O'Donnell, Matej Oresic, Arvind Ramanathan, Daisuke Saigusa, Heidi Schwartz-Zimmermann, Guanghou Shui, Masatomo Takahashi, Margret Thorsteinsdottir, Anthony Tournadre, Hiroshi Tsugawa, Victoria Tyrrell, Grace van der Gugten, Michael Wakelam, Craig Wheelock, Denise Wolrab, Guowang Xu, John Bowden, Kim Ekroos, Robert Ahrends, Markus Wenk
In this community effort, we compared measurements between 34 laboratories from 19 countries, utilizing mixtures of authentic synthetic standards, to quantify by mass spectrometry four ceramide species in the NIST human blood plasma Standard Reference

Jointly benchmarking small and structural variant calls with vcfdist

October 2, 2024
Author(s)
Tim Dunn, Justin Zook, James Holt, Satish Narayanasamy
In this work, we extend vcfdist to be the first variant call benchmarking tool to jointly evaluate phased single-nucleotide polymorphisms (SNPs), small insertions/deletions (INDELs), and structural variants (SVs) for the whole genome. First, we find that a

Value assignment and uncertainty evaluation for certified reference gas mixtures

September 9, 2024
Author(s)
Christina Cecelski, Jennifer Carney, Antonio Possolo
The procedures used to assign values to certified reference gas mixtures and to evaluate their associated uncertainties, which are described in ISO 6143, and that were variously improved by Guenther and Possolo (Anal Bioanal Chem 399:489–500, 2011. 10.1007

Metabolomics 2023 Workshop Report: Moving Toward Consensus on Best QA/QC Practices in LC-MS-Based Untargeted Metabolomics

July 9, 2024
Author(s)
Tracey Schock, Jonathan Mosley, Warwick Dunn, Julia Kuligowski, Matthew Lewis, Maria Monge, Candice Ulmer Holland, Dajana Vuckovic, Krista Zanetti
Introduction: During the Metabolomics 2023 conference, the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) presented a workshop focusing on key quality assurance and quality control (QA/QC) topic categories for LC-MS-based untargeted

Certification of Standard Reference Material(R) 1955a Homocysteine in Frozen Human Serum

June 21, 2024
Author(s)
Carolyn Burdette, Elena Wood, Jerome Mulloor, Michael Nelson, Blaza Toman, Aaron Urbas
Standard Reference Material (SRM) 1955a Homocysteine in Frozen Human Serum is intended for use in validating homocysteine measurement procedures used by in vitro diagnostics manufacturers, reference laboratories, and clinical laboratories in the United

Characterization of Reference Material 8210: Hemp Plant

June 20, 2024
Author(s)
Colleen E. Bryan Sallee, Walter Brent Wilson, Charles Barber, Monique Johnson, Jenna Klingsick, Jerome Mulloor, Blaza Toman, Elena Wood, Laura Wood, Andrea Yarberry
The National Institute of Standards and Technology (NIST) Reference Material (RM) 8210 Hemp Plant delivers non certified values for cannabinoids and toxic elements in a dried ground hemp plant material to help cannabis and forensic laboratories for use as

Homogenization of Large Batch Frozen Materials Using the Palla-VM-KT Vibrating Mill

May 21, 2024
Author(s)
Debra Ellisor, Amanda Moors, Jennifer Hoguet, Jennifer Ness, Amanda Capuano, Olivia Franco
The Biospecimen Science Group at the National Institute of Standards and Technology (NIST) Biorepository has been responsible for the curation, maintenance, and preparation of biological specimens at cryogenic temperatures since 2002. The team's expertise

Traceable localization enables accurate integration of quantum emitters and photonic structures with high yield

March 18, 2024
Author(s)
Craig R. Copeland, Adam L. Pintar, Ronald G. Dixson, Ashish Chanana, Kartik Srinivasan, Daron Westly, Robert Ilic, Marcelo Davanco, Samuel M. Stavis
In a popular integration process for quantum information technologies, localization microscopy of quantum emitters guides lithographic placement of photonic structures. However, a complex coupling of microscopy and lithography errors degrades registration

Differential scanning calorimetry (DSC): An important tool for polymer identification and characterization of plastic marine debris

February 19, 2024
Author(s)
Jennifer Lynch, Raquel Corniuk, Kayla C. Brignac, Melissa Jung, Joelle Marchiani, Wanda Weatherford
Differential scanning calorimetry (DSC), a routine thermoanalytical method in material science, is gaining utility in plastic pollution research to improve polymer identification. We optimized a DSC method, experimentally testing pan types, temperature

Measurement of 100 nm Monodisperse Particles by Four Accurate Methods: Uncertainty and Traceability

February 12, 2024
Author(s)
George Mulholland, Kaleb Duelge, Vincent A. Hackley, Natalia Farkas, John A. Kramar, Keiji Takahata, Michael Zachariah, Hiromu Sakurai, Kensei Ehara
Accurate measurements of particle diameter are necessary for quantitative characterization of key aerosol properties including the Cunningham slip correction, charging probability, the diffusion coefficient, the coagulation coefficient, and optical

Certification of Standard Reference Material(R) 2983 Inorganics in Geoduck Clam Tissue (Panopea generosa)

January 29, 2024
Author(s)
Colleen E. Bryan Sallee, Melannie Bachman, Steven J. Christopher, Debra Ellisor, Michael Ellisor, Jennifer Hoguet, Samuel Huntington, Caleb Luvonga, Amanda Moors, Dhayaalini Nadarajan, Tomohiro Narukawa, Jennifer Ness, Rebecca Pugh, James H. Yen, Lee L. Yu
Standard Reference Material (SRM) 2983 Inorganics in Geoduck Clam Tissue (Panopea generosa) is intended to be used for the evaluation of methods for the determination of elements, arsenic species, and proximates in this and similar matrices. A unit of SRM

Dietary Supplement Laboratory Quality Assurance Program: Exercise 1 Final Report

November 1, 2023
Author(s)
Carolyn Burdette, Hugh Hayes, Jenna Klingsick, Colleen E. Bryan Sallee, Charles Barber, Steven J. Christopher, Lee L. Yu
The DSQAP was launched, in collaboration with the NIH ODS, in 2007. The program was established to enable laboratories to improve the accuracy of measurements in samples for nutrients, marker compounds, toxic elements, and/or contaminants in dietary