NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.

Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.

U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PUBLICATIONS

Certification of Standard Reference Material® 956e Electrolytes in Frozen Human Serum

Published

Author(s)

Lee Yu, Steven Christopher, Regina Easley, Monique Johnson, Dennis Leber, Thomas Vetter, Jason Waters, Charles Barber, Karen Murphy, Laura Wood, Stephen Chin, Murli Narayan, Alexander Rhodes, Michael Nash

Abstract

The National Institute of Standards and Technology (NIST) Standard Reference Material® (SRM®) 956e Electrolytes in Frozen Human Serum is intended for use in the calibration and validation of procedures and methods employed in clinical analysis for the determination of electrolytes in either diluted or undiluted human serum or plasma. This SRM can be used for calibrating direct-reading ion-selective electrode (ISE) analyzers, and for validating methods used to measure electrolytes in similar matrices. The material was produced commercially in accordance with the protocol described in Clinical Laboratory Standards Institute (CLSI) Standard C29-A2, Standardization of Sodium and Potassium Ion-Selective Electrode Systems to the Flame Photometric Reference Method. This publication documents the production, analytical measurements, and statistical evaluations leading to the certification of the SRM.
Citation
Special Publication (NIST SP) - 260-254
Report Number
260-254
NIST Pub Series
Special Publication (NIST SP)
Pub Type
NIST Pubs

Download Paper

https://doi.org/10.6028/NIST.SP.260-254
Local Download

Keywords

Electrolyte, Human serum, Standard Reference Material (SRM), Calcium (Ca), Ionized calcium (iCa), Chloride (Cl-), Lithium (Li), Magnesium (Mg), Phosphorus (P), Potassium (K), Sodium (Na), Ion selective electrode.
Reference materials, Quality assurance, Analytical chemistry and Amount of substance

Citation

Yu, L. , Christopher, S. , Easley, R. , Johnson, M. , Leber, D. , Vetter, T. , Waters, J. , Barber, C. , Murphy, K. , Wood, L. , Chin, S. , Narayan, M. , Rhodes, A. and Nash, M. (2025), Certification of Standard Reference Material® 956e Electrolytes in Frozen Human Serum, Special Publication (NIST SP), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://doi.org/10.6028/NIST.SP.260-254, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=959702 (Accessed October 3, 2025)

Issues

If you have any questions about this publication or are having problems accessing it, please contact [email protected].

Created April 2, 2025
Was this page helpful?