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Physics

Biological Physics

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Displaying 151 - 175 of 197

Immobilization of Proteins on Carboxylic Acid-Functionalized Nanopatterns

November 28, 2012
Author(s)
John Peter Ngunjiri, Daniel J. Stark, Tian Tian, Kimberly Briggman, Jayne C. Garno
The immobilization of proteins on nanopatterned surfaces was investigated using in situ atomic force microscopy (AFM) and ex situ infrared reflectance-absorption spectroscopy (IRAS). The AFM-based lithography technique of nanografting provided control of

PEG-Labeled Nucleotides and Nanopore Detection for Single Molecule DNA Sequencing by Synthesis

September 21, 2012
Author(s)
Shiv Kumar, Tao Chuanjuan, Chien Minchen, Hellner Brittney, Joseph W. Robertson, Arvind Balijepalli, Li Zengmin, James J. Russo, Joseph E. Reiner, John J. Kasianowicz, Jingyue Ju
There is a significant need to accurately sequence single DNA and RNA molecules for personalized medicine. We describe a novel nanopore-based sequencing by synthesis (SBS) strategy that will accurately differentiate at single molecule level four different

Out-of-plane Stokes imaging polarimeter for early skin cancer diagnosis

July 1, 2012
Author(s)
P. Ghassemi, Paul Lemaillet, Thomas Germer, J. W. Shupp, S. Venna, M. E. Boisvert, K. E. Flanagan, M. H. Jordan, J. C. Ramella-Roman
Optimal treatment of skin cancer before it metastasizes depends critically on early diagnosis and treatment. Imaging spectroscopy and polarized remittance have been utilized in the past for diagnostic purposes, but valuable information can be also obtained

Pronounced micro-segregation in a sorbitol water mixture observed through variable temperature neutron scattering

May 16, 2012
Author(s)
Shin G. Chou, Sheila Khodadadi, Joseph E. Curtis, Susan Krueger, Evgenyi Shalaev, Alan Soper, Andy Fitch, T Narayanan, Michael Szutucki, Marcus T. Cicerone
In this study, we use small and wide angle X-ray and neutron scattering measurements, to study the structure of concentrated sorbitol solutions and glasses at different temperatures. The analysis of the data suggests the water forms clusters with a

Relationship between Length and Surface-Enhanced Raman Spectroscopy signal Strength in Metal Nanoparticle Chains: Idea Models versus Nanofabrication

January 18, 2012
Author(s)
Angela R. Hight Walker, K. Stec, Shunpig Zhang, Hongxing Xu, Rene Lopez
We have employed capillary force deposition on ion beam patterned substrates to fabricate chains of 60nm gold nanospheres ranging in length from 1 to 9 nanoparticles. Measurements of the surface-averaged SERS enhancement factor strength for these chains

DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT

October 3, 2011
Author(s)
Samuel Stavis, Jon Geist, Michael Gaitan, Laurie E. Locascio, Elizabeth Strychalski
Entropophoresis - motion caused by an entropy gradient - is a novel nanofluidic method to direct the self-transport of biopolymers that established a new paradigm of nanofluidic functionality with broad relevance to lab-on-a-chip technol-ogy. Here, the

SEM Induced Shrinking of Solid State Nanopores for Single Molecule Detection

September 22, 2011
Author(s)
Anmiv Prahbu, Kevin J. Freedman, Joseph W. Robertson, Zhorro Nikolov, John J. Kasianowicz, MinJun Kim
We have investigated the shrinkage of solid state nanopores by a scanning electron microscope and find the process to be reproducible and dependant beam parameters such as the accelerating voltage and electron flux. The shrinking phenomenon does not

The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): A Completed Reference Database of Lung Nodules on CT Scans

January 28, 2011
Author(s)
Charles D. Fenimore, Samuel Armato, Denise Aberle, Matthew Brown, Claudia Henschke, Michael McNitt-Gray, Heber MacMahon, Geoffrey McLennan, Charles R. Meyer, Anthony P. Reeves, David F. Yankelevitz
The development of computer-aided diagnostic (CAD) methods for lung nodule detection, classification, and quantitative assessment can be facilitated through a well-characterized repository of computed tomography scans. The Lung Image Database Consortium

Time-resolved radiation beam profiles in water obtained by ultrasonic tomography

December 31, 2010
Author(s)
Eugene Malyarenko, Joseph Heyman, Heather H. Chen-Mayer, Ronald Tosh
This paper presents a practical ultrasonic system for near real-time imaging of spatial temperature distributions in water caused by absorption of radiation. Initial testing with radiation from a highly attenuated infrared lamp demonstrates that the system
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