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Physics

Biological Physics

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Displaying 151 - 175 of 378

High-speed alignment optimization of digital optical phase conjugation systems based on autocovariance analysis in conjunction with orthonormal rectangular polynomials

August 28, 2018
Author(s)
Ashton S. Hemphill, Yuecheng Shen, Jeeseong C. Hwang, Lihong V. Wang
Digital optical phase conjugation (DOPC) enables many optical applications by permitting focusing of light through scattering media. However, DOPC systems require precise alignment of all optical components, particularly of the spatial light modulator (SLM

PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer

August 2, 2018
Author(s)
Alexander Grishaev, Xingcheng Lin, Mohit Jolly, Federico Bocci, Nicholas Schafer, Min-Yeh Tsai, Yihong Chen, Yanan He, Keith Weninger, John Orban, Prakash Kulkarni, Govindan Rangarajan, Herbert Levine, Jose Onuchic
Prostate-Associated Gene 4 (PAGE4) is a disordered protein implicated in the progression of prostate cancer. PAGE4 can be phosphorylated at two residue sites by Homeodomain-Interacting Protein Kinase 1 (HIPK1) to facilitate its binding to the Activator

A Spin-1 Representation for Dual-Funnel Energy Landscapes

July 20, 2018
Author(s)
Justin E. Elenewski, Kirill Velizhanin, Michael P. Zwolak
The interconversion between left- and right-handed helical folds of a polypeptide defines a dual-funneled free energy landscape. In this context, the funnel minima are connected through a continuum of unfolded conformations, evocative of the classical

Polyelectrolyte association and solvation

July 10, 2018
Author(s)
Alexandros Chremos, Jack F. Douglas
There has been significant interest in the tendency of highly charged particles having the same charge to form dynamic clusters in solution, but an accepted theoretical framework that can account for this ubiquitous phenomenon has been slow to develop. The

Golden aspect ratio for ion transport simulation in nanopores

July 5, 2018
Author(s)
Subin Sahu, Michael P. Zwolak
Access resistance indicates how well current carriers from the bulk medium can converge to a pore or opening, and is important in many fields, such as cell biology, electronics, electrochemical engineering, thermal transport, among others. In simplified

A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity

May 24, 2018
Author(s)
Subrata Debnath, Dalibor Kosek, Harichandra Tagad, Stewart R. Durell, Daniel Appella, Roderico Acevedo, Alexander Grishaev, Fred Dyda, Ettore Appella, Sharlyn Mazur
Metal-dependent protein phosphatases (PPM) are evolutionarily unrelated to other serine/threonine protein phosphatases and are characterized by their requirement for supplementation with millimolar concentrations of Mg2+ or Mn2+ ions for activity in vitro

Determining the physical properties of molecules with nanometer-scale pores

January 30, 2018
Author(s)
Haiyan Wang, Jessica Ettedgui, Jacob Fortater, Joseph W. Robertson, Joseph Reiner, Huisheng Zhang, Siping Chen, John J. Kasianowicz
Nanometer-scale pores have recently been developed for the detection, characterization, and quantitation of a wide range of analytes (e.g., ions, polymers, proteins, anthrax toxins, neurotransmitters, and synthetic nanoparticles), and for DNA sequencing

Maxwell-Hall access resistance in graphene nanopores

January 24, 2018
Author(s)
Subin Sahu, Michael P. Zwolak
The resistance due to the convergence from bulk to a constriction -- e.g., a nanopore -- is a mainstay of transport phenomena. In classical electrical conduction, Maxwell -- and later Hall for ionic conduction -- predicted this access or convergence

Zinc Doped Copper Ferrite Particles as Temperature Sensors for Magnetic Resonance Imaging

December 27, 2017
Author(s)
Karl Stupic, Janusz H. Hankiewicz, Zbigniew Celinski, Robert E. Camley, Marek Przybylski, Jan Zukrowski, Nick Anderson, Noweir Alghamdi, Nicholas Hammelev
We investigate the use of Cu0.35Zn0.65Fe2O4 particles as temperature-dependent sensors in magnetic resonance imaging (MRI). This material has a Curie temperature near 290 K, but in the large magnetic fields found in MRI scanners there is a significant

Hybrid Applications of Solution Scattering to Aid Structural Biology

November 19, 2017
Author(s)
Alexander Grishaev
Biomolecular applications of solution X-ray and neutron scattering (SAXS and SANS, respectively) started in late 1960s – early 1970s but were relatively limited in their ability to provide a detailed structural picture and lagged behind what became the two
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