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Determining the physical properties of molecules with nanometer-scale pores



Haiyan Wang, Jessica Ettedgui, Jacob Fortater, Joseph W. Robertson, Joseph Reiner, Huisheng Zhang, Siping Chen, John J. Kasianowicz


Nanometer-scale pores have recently been developed for the detection, characterization, and quantitation of a wide range of analytes (e.g., ions, polymers, proteins, anthrax toxins, neurotransmitters, and synthetic nanoparticles), and for DNA sequencing. We describe the key requirements that made this method possible and how the technique evolved. Finally, we show that, despite sound theoretical work, which advanced both the conceptual framework and quantitative capability of the method, there are still unresolved questions that need to be addressed to further improve the technique.
ACS Sensors


Nanopores, ion channels, sensors, analyte detection, DNA sequencing, microRNA, protein-DNA interactions, chemically modified nanopore, gold nanoclusters, metallonanoclusters
Created January 30, 2018, Updated November 10, 2018