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Health / Clinical diagnostics

Medical imaging

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Displaying 101 - 125 of 128

Prototype Phantoms for Characterization of Ultra-Low Field Magnetic Resonance Imaging

November 26, 2013
Author(s)
Michael A. Boss, John A. Mates, Sarah E. Busch, Paul SanGiorgio, Stephen E. Russek, Kai Buckenmaier, Kent D. Irwin, Hsiao-Mei Cho, Gene C. Hilton, John Clarke
Purpose: Prototype phantoms were designed, constructed, and characterized for the purpose of calibrating ultralow field magnetic resonance imaging (ULF MRI) systems. The phantoms were designed to measure spatial resolution and to quantify sensitivity to

ToF-SIMS 3D Imaging of Native and Non-Native Species within HeLa Cells

November 26, 2013
Author(s)
Jeremy Brison, Michael A. Robinson, Danielle S. Benoit, Shinichiro Muramoto, Patrick S. Stayton, David G. Castner
In this study, a non-native chemical species, bromodeoxyuridine (BrdU), was imaged within single HeLa cells using time-of-flight secondary ion mass spectrometry (ToF-SIMS). The z-axis corrected 3D images were reconstructed that accurately portray the

Statistical Analysis of Reader Measurement Variability in Nodule Sizing with CT Phantom Imaging Data

November 23, 2012
Author(s)
John Lu, Charles D. Fenimore, Nicholas Petrick, Rongping Zeng, Marios A. Gavrielides, David Clunie, Kristin Borradaile, Robert Ford, Hyun J. Kim, Michael McNitt-Gray, Binsheng Zhao, Andrew Buckler
RSNA has conducted a phantom quantitative imaging biomarker (QIBA) study to assess reader measurement variability of both spherical and non-spherical nodules using CT imaging. Statistical analysis of intra-reader and inter-reader variability of volume

Review: Biological Imaging Software Tools

August 29, 2012
Author(s)
Anne L. Plant, Kevin Eliceiri, Anne Carpenter
Few technologies are more widespread in modern biological laboratories than imaging by microscopy. Advancements in optical technologies and instrumentation over the past twenty years have led to massive improvements in the resolution, specificity

Out-of-plane Stokes imaging polarimeter for early skin cancer diagnosis

July 1, 2012
Author(s)
P. Ghassemi, Paul Lemaillet, Thomas Germer, J. W. Shupp, S. Venna, M. E. Boisvert, K. E. Flanagan, M. H. Jordan, J. C. Ramella-Roman
Optimal treatment of skin cancer before it metastasizes depends critically on early diagnosis and treatment. Imaging spectroscopy and polarized remittance have been utilized in the past for diagnostic purposes, but valuable information can be also obtained

Hyperspectral Imaging of Ischemic Wounds

February 1, 2012
Author(s)
David W. Allen
Optical imaging has the potential to achieve high spatial resolution and high functional sensitivity in wound assessment. However, clinical acceptance of many optical imaging devices is hampered by poor reproducibility, low accuracy, and lack of biological

Controlled transport of superparamagnetic beads with spin-valves

October 7, 2011
Author(s)
Wendy R. Altman, John M. Moreland, Stephen E. Russek, Bruce W. Han, Victor M. Bright
Trapping, release, and transport of individual or ensembles of 2.8 υm superparamagnetic beads functionalized with streptavidin were demonstrated using an addressable and non-volatile array of spin-valve (SV) traps integrated into a microfluidic channel

Tumor volume measurement errors RECIST studied with realistic tumor models

May 16, 2011
Author(s)
Benjamin R. Galloway, Adele Peskin, Zachary H. Levine
RECIST (Response Evaluation Criteria in Solid Tumors) is a linear measure intended to predict tumor volume in medical computed tomography (CT). In this work, using purely geometrical considerations, we estimate how well RECIST can predict the volume of

Reproducibility and Robustness of a Real-Time Microfluidic Cell Toxicity Assay

May 15, 2011
Author(s)
Gregory A. Cooksey, John T. Elliott, Anne L. Plant
Numerous opportunities exist to apply microfluidic technology to high-throughput and high-content cell-based assays. However, maximizing the value of these assays for drug discovery, screening or toxicity evaluation, for example, will require validation of

Data Sets for the Qualification of Volumetric CT as a Quantitative Imaging Biomarker in Lung Cancer

October 20, 2010
Author(s)
Charles D. Fenimore, Andrew Buckler, Lawrence H. Schwartz, Nicholas Petrick, Michael McNitt-Gray, Binsheng Zhao, Anthony P. Reeves, P. David Mozeley, Ricardo S. Avila
The drug development industry is faced with increasing costs and decreasing success rates. New ways to understand biology as well as the increasing interest in personalized treatments for smaller patient segments requires new capabilities for the rapid

Monitoring Photothermally Excited Nanoparticles via Multimodal Microscopy

May 19, 2010
Author(s)
Matthew L. Clarke, Shin G. Chou, Jeeseong Hwang
Generation of heat using optically excited nanoparticles can be beneficial or detrimental depending on the application. Therefore, clinically applicable studies are being pursued in an effort to achieve safe practices of nanoparticle-induced hyperthermia

Fluorinated Copolymer Nanoparticles for Multimodal Imaging Applications

February 18, 2010
Author(s)
Mark M. Bailey, Christine M. Mahoney, Elodie Dempah, Jeffrey M. Davis, Matthew Becker, Supang Khondee, Eric J. Munson, Cory J. Berkland
Nanomaterials have emerged as valuable tools in biomedical imaging techniques, such as magnetic resonance imaging (MRI), fluorescence, positron emission tomography (PET), and others. Some have been designed to serve as multimodal imaging agents, combining

Low-Cost, High-Throughput, Automated Counting of Bacterial Colonies

January 5, 2010
Author(s)
Matthew L. Clarke, Robert L. Burton, A. N. Hill, Maritoni A. Litorja, Moon H. Nahm, Jeeseong Hwang
Research involving bacterial pathogens often requires enumeration of bacteria colonies. Here we present a low-cost, high-throughput colony counting system consisting of colony counting software and a consumer-grade digital camera or document scanner. We

A Quality Pre-Processor for Biological Cell Images

November 30, 2009
Author(s)
Adele P. Peskin, Karen Kafadar, Alden A. Dima
We have developed a method to rapidly test the quality of a biological image, to identify appropriate segmentation methods, if any, that will render high quality segmentations for the cells within that image. The key contribution is the development of a

Robust Volume Calculations of Tumors of Various Sizes

July 13, 2009
Author(s)
Adele P. Peskin, Karen Kafadar, A.M. Santos, Gillian Haemer
Many advances in medicine today require the accurate reading of computerized tomographic (CT) images of the body. Tumors in the lung, for example, are classified according to their detected growth, i.e. change in volume, over a period of time. CT data are

Synthetic Lung Tumor Data Sets for Comparison of Volumetric Algorithms

July 13, 2009
Author(s)
Adele P. Peskin, Alden A. Dima, Javier Bernal, David E. Gilsinn, Karen Kafadar
The change in pulmonary nodules over time is an important indicator of malignant tumors. It is therefore important to be able to measure change in the size of tumors from computed tomography (CT) data taken at different times and on potentially different

Pulse shaping for background free broadband CARS

March 16, 2009
Author(s)
Young Jong Lee, Marcus T. Cicerone
We demonstrate that pulse shaping of a probe pulse can suppress the nonresonant background (NRB) contribution and retrieve resonant Raman signal efficiently in broadband coherent anti-Stokes Raman scattering (CARS) spectrum. A pulse shaper prepares a probe

Surface plasmon resonance imaging of cells and surface-associated fibronectin

February 26, 2009
Author(s)
Alexander W. Peterson, Michael W. Halter, Alessandro Tona, Kiran Bhadriraju, Anne L. Plant
Background A critical challenge in cell biology is quantifying the interactions of cells with their extracellular matrix (ECM) environment and the active remodeling by cells of their ECM. Fluorescence microscopy is a commonly employed technique for
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