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Health / Clinical diagnostics

Medical imaging

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Displaying 76 - 100 of 128

An update on dose calibrator settings for nuclides used in nuclear medicine

June 1, 2018
Author(s)
Denis E. Bergeron, Jeffrey T. Cessna
Most clinical measurements of radioactivity, whether for therapeutic or imaging nuclides, rely on commercial reentrant ionization chambers (“dose calibrators”). The National Institute of Standards and Technology (NIST) maintains a battery of representative

Standardization of 64Cu activity

May 25, 2018
Author(s)
Denis E. Bergeron, Jeffrey T. Cessna, Ryan P. Fitzgerald, Leticia S. Pibida, Brian E. Zimmerman
The complex decay scheme that makes 64Cu promising as both an imaging and therapeutic agent in medicine also makes the absolute measurement of its activity challenging. The National Institute of Standards and Technology (NIST) has completed a primary

Magnetic Resonance Imaging Biomarker Calibration Service: Proton Spin Relaxation Times

May 3, 2018
Author(s)
Michael A. Boss, Andrew M. Dienstfrey, Zydrunas Gimbutas, Kathryn E. Keenan, Jolene D. Splett, Karl F. Stupic, Stephen E. Russek
This document describes the calibration service to measure proton spin relaxation times, T1 and T2, of materials used in phantoms (calibration artifacts) to verify the accuracy of MRI-based quantitative measurements. Proton spin relaxation times are used

Correction of an adding-doubling inversion algorithm for the measurement of the optical parameters of turbid media

January 1, 2018
Author(s)
Paul Lemaillet, Catherine C. Cooksey, Jeeseong Hwang, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, David W. Allen
We present broadband measurements of the optical properties of tissue-mimicking solid phantoms using a single integrating sphere to measure the hemispherical reflectance and transmittance under a direct illumination at the normal incident angle. These

Quantitative Magnetic Resonance Imaging Phantoms: A Review and the Need for a System Phantom

October 4, 2017
Author(s)
Kathryn E. Keenan, Maureen Ainslie, Alexander J. Barker, Michael A. Boss, Kim M. Cecil, Cecil Charles, Thomas L. Chenevert, Laurence Clarke, Jeffrey L. Evelhoch, Paul Finn, Guoying Liu, Stephen E. Russek, Karl F. Stupic, Joshua D. Trzasko, Chun Yuan, Jie Zheng
The MRI community is using quantitative mapping techniques to complement qualitative imaging. For quantitative imaging to reach its full potential, it is necessary to analyze measurements across systems and longitudinally. Clinical use of quantitative

Accuracy, repeatability and interplatform reproducibility measurements of T 1 quantification methods used for DCE-MRI: results from a multicenter phantom study.

August 16, 2017
Author(s)
Octavia Bane, Stefanie J. Hectors, Mathilde Wagner, Lori L. Arlinghaus, Madhava P. Aryal, Yue Cao, Thomas L. Chenevert, Fiona Fennessy, Wei Huang, Nola M. Hylton, Jayashree Kalpathy-Cramer, Katy Keenan, Dariya I. Malyarenko, Robert V. Mulkern, David C. Newitt, Stephen E. Russek, Karl Stupic, Michael A. Boss
Purpose: To determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T 1 quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3 T. Methods: A T 1 phantom with 14 samples was imaged at eight

Standardizing CT Lung Density Measure Across Scanner Manufacturers

March 1, 2017
Author(s)
Huaiyu H. Chen-Mayer, Matthew Fuld, Bernice Hoppel, Phillip Judy, Junfeng Guo, David Lynch, Antonio M. Possolo, Sean B. Fain
Computed Tomography imaging of the lung, reported in Hounsfield Units (HU), can be parameterized as a quantitative image biomarker for the diagnosis and monitoring of lung density changes due to emphysema, a type of chronic obstructive pulmonary disease

Multispectral MR imaging and sensing using shaped nanoparticles

November 26, 2016
Author(s)
Gary Zabow
The idea that size and shape can determine color is well known in optics-based quantum dot and plasmonic nanoparticle fields. But what about in the radio-frequency (RF) portion of the spectrum? This chapter reviews recent work on specially shaped magnetic

The Comet Assay: Methods for Quantitative Image Analysis and Reproducibility

September 1, 2016
Author(s)
Donald H. Atha, Signe Braafladt, Vytautas Reipa
The comet assay,or single cell gel electrophoresis,is a sensitive and efficient technique for analyzing DNA damage in the form of single and double strand breaks in single cells. DNA alteration,from strand breaks,can lead to cancer and other health risks

Wide-field quantitative imaging of tissue microstructure using high-frequency structured light

June 9, 2016
Author(s)
David McClatchy III, Elizabeth Rizzo, wendy wells, Jeeseong C. Hwang, keith paulson, Brian Pogue, Stephen Kanick
Sub-diffusive structured light imaging has been shown to accurately and quantitatively map the reduced scattering coefficient and the phase function backscatter parameter in a wide-field geometry. This study shows the first the experimental imaging of

3D Segmentation of Stem Cells from Thousands of Confocal Microscopy Images

March 1, 2016
Author(s)
Peter Bajcsy, Mylene H. Simon, Stephen J. Florczyk, Carl G. Simon Jr., Derek Juba, Mary C. Brady
We address the problem of estimating 3D segmentation performance when segmentation is applied to thousands of confocal microscopy images (z-stacks) of cells. With a very large number of z-stacks, manual inputs to validate each segmentation result are

Design of a breast phantom for quantitative MRI

January 1, 2016
Author(s)
Kathryn E. Keenan, Sheye O. Aliu, Lisa J. Wilmes, David C. Newitt, Ella F. Jones, Wen Li, Michael A. Boss, Nola M. Hylton
Purpose: We present a breast phantom designed to enable quantitative assessment of measurements of T 1 relaxation time, apparent diffusion coefficient (ADC), and other attributes of breast tissue, with long-term support from a national metrology institute

Beam-Scanning for Rapid Coherent Raman Hyperspectral Imaging

December 14, 2015
Author(s)
Seungwan Ryu, Charles Camp, Ying Jin, Marcus T. Cicerone, Young Jong Lee
Coherent Raman imaging requires high peak power laser pulses to maximize the nonlinear multiphoton signal generation, but accompanying photo-induced sample damage often poses a challenge to microscopic imaging studies. We demonstrate that a beam-scanning

Quantitative scheme for full-field polarization rotating fluorescence microscopy (PROM) using a liquid crystal variable retarder

May 14, 2015
Author(s)
John F. Lesoine, Ji Y. Lee, Hyeong G. Kang, Matthew L. Clarke, Robert C. Chang, Ralph Nossal, Jeeseong C. Hwang
We introduce real-time, full-field, polarization rotating fluorescence microscopy (PROM) to monitor the absorption dipole orientations of fluorescent molecules. A quarter-wave plate, in combination with a liquid crystal variable retarder (LCVR), provides a

Evaluation of Low-Contrast Detectability of Iterative Reconstruction across Multiple Institutions, CT Scanner Manufacturers, and Radiation Exposure Levels

February 19, 2015
Author(s)
Adele P. Peskin, Ganesh Saiprasad, James J. Filliben, Alden A. Dima
Purpose: To evaluate the impact of Iterative Reconstruction (IR) compared with Filtered Back Projection (FBP) using low-contrast objects in phantom images across vendors and exposure levels. Materials and Methods: Randomized repeat scans of the Gammex 464

Automated Ranking of Stem Cell Colonies by Translating Biological Rules to Computational Models

September 20, 2014
Author(s)
Adele P. Peskin, Steven P. Lund, YaShian Li-Baboud, Michael W. Halter, Anne L. Plant, Peter Bajcsy
This paper addresses the problem of automating an image ranking process for stem cell colonies. We automate the manual process in a novel way: instead of fitting off-the-shelf image features and colony ranks to prediction models, we define a new feature

Performance Benchmarking and Intensity Calibration of a Widefield Fluorescence Microscope Using Fluorescent Glass

August 11, 2014
Author(s)
Michael W. Halter, Elianna Bier, Paul C. DeRose, Gregory A. Cooksey, Steven J. Choquette, Anne L. Plant, John T. Elliott
Widefield fluorescence microscopy is a highly used tool for visually assessing biological samples and for quantifying cell responses. Despite its widespread use in high content analysis and other screening applications, few published methods exist for

High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues

July 20, 2014
Author(s)
Charles H. Camp, Young J. Lee, John M. Heddleston, Christopher M. Hartshorn, Angela R. Hight Walker, Jeremy N. Rich, Justin D. Lathia, Marcus T. Cicerone
We have developed a coherent Raman imaging platform using broadband coherent anti-Stokes Raman scattering (BCARS) that provides an unprecedented combination of speed, sensitivity, and spectral breadth. The system utilizes a unique configuration of laser
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