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Health

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Displaying 351 - 375 of 1608

Conformational Changes in Active and Inactive States of Human PP2C? characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry

May 8, 2017
Author(s)
Sharlyn Mazur, Elyssia S. Gallagher, Subrata Debnath, Stewart R. Durell, Kyle Anderson, Lisa M. Jenkins, Ettore Appella, Jeffrey W. Hudgens
PPM serine/threonine protein phosphatases function in signaling pathways and require millimolar concentrations of Mn2+ or Mg2+ ions for activity. Whereas the crystal structure of human PP2Cα displayed two tightly bound Mn2+ ions in the active site, recent

Biofilm Over Teeth and Restorations, What Do We Need to Know?

March 31, 2017
Author(s)
Nancy Lin
Objectives The goal of this paper is to provide an overview of biofilms and biofilm measurements in the context of studying biofilms on tooth and dental material surfaces to improve oral health. Methods A historical perspective and terminology is presented

Life Time Dosimetric Assessment for Mice and Rats Exposed to Cell Phone Radiation in Reverberation Chambers

March 17, 2017
Author(s)
Perry F. Wilson, John M. Ladbury, Galen H. Koepke, Yijian Gong, Myles Capstick, Keven Kuhn, David L. McCormick, Ronald L. Melnick, Niels Kuster
In this paper, we present a detailed life time dosimetry analysis for individually housed rodents exposed to radio frequency (RF) signals. The unrestrained rodents were exposed in reverberation chambers for 2 years at three whole-body averaged specific

Neuroelectronic Device Process Development and Challenge

March 16, 2017
Author(s)
Jessie Zhang, Gymama Slaughter, Matthew Robinson, Joel Tyson
One of the major challenges of brain activity monitoring is to obtain high quality signals from the brain using metal electrodes. The probes consisting of metal electrodes have to be thin enough without damaging the tissue while maintaining good contact to

NIST Micronutrients Measurement Quality Assurance Program Winter and Summer 2016 Comparability Studies: Results for Round Robin LXXIX and LXXX Fat-Soluble Vitamins and Carotenoids in Human Serum

March 16, 2017
Author(s)
Jeanice M. Brown Thomas, David L. Duewer
The National Institute of Standards and Technology coordinates the Micronutrients Measurement Quality Assurance Program (MMQAP) for laboratories that measure fat-soluble vitamins and carotenoids in human serum and plasma. This report describes the design

Enhancing the Efficacy of Cancer Therapy: Use of Small Molecule Inhibitors of DNA Glycosylases as Potential Drugs

March 12, 2017
Author(s)
Erdem Coskun, Aaron C. Jacobs, Nathan Donley, Marcus J. Calkins, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Amanda K. McCullough, M Miral Dizdar, R. S. Lloyd
Chemotherapy aims to destroy cancer cells by damaging their DNA. However, the overexpression of DNA repair proteins in cancer cells causes the removal of DNA lesions before they become toxic and thus leads to an increased DNA repair capacity resulting in

Experimental and statistical methods to evaluate antibacterial activity of a quaternary pyridinium salt on planktonic, biofilm-forming, and biofilm states

March 3, 2017
Author(s)
Daneli Lopez-Perez, Paula J. Baker, Adam L. Pintar, Jirun Sun, Nancy Lin, Sheng Lin-Gibson
Robust evaluation and comparison of antimicrobial technologies are critical to improving biofilm prevention and treatment. Herein, a multi-pronged experimental framework and statistical models were applied to determine the effects of quaternary pyridinium

Standardizing CT Lung Density Measure Across Scanner Manufacturers

March 1, 2017
Author(s)
Huaiyu H. Chen-Mayer, Matthew Fuld, Bernice Hoppel, Phillip Judy, Junfeng Guo, David Lynch, Antonio M. Possolo, Sean B. Fain
Computed Tomography imaging of the lung, reported in Hounsfield Units (HU), can be parameterized as a quantitative image biomarker for the diagnosis and monitoring of lung density changes due to emphysema, a type of chronic obstructive pulmonary disease