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Rapid DNA melting analyses using a microfabricated electrochemical platform



Zuliang Shen, Stephen Semancik, Herman O. Sintim


A new microscale platform is reported which is based on microfabrication methods that integrate thermal control and multi-electrode components to enable rapid temperature-dependent electrochemical measurements on small volume fluid samples. We demonstrate the device's capabilities by performing melting curve analyses for single-nucleotide polymorphism (SNP) detection.
Analytica Chimica ACTA


DNA melting temperature: electrochemical melting, microfabrication, electrochemical platform, micro heater, single-nucleaotide polymorphism, methylene blue, square wave volammetry


Shen, Z. , Semancik, S. and Sintim, H. (2015), Rapid DNA melting analyses using a microfabricated electrochemical platform, Analytica Chimica ACTA, [online], (Accessed July 21, 2024)


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Created December 31, 2014, Updated October 12, 2021