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Bioscience

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Displaying 876 - 900 of 1261

Analysis of potential cancer biomarkers in mitochondrial DNA

December 1, 2006
Author(s)
J P. Jakupciak, G. D. Dakubo, Samantha D. Maragh, R. L. Parr
Understanding mitochondrial biology is a fundamental research goal in human genetics and medicine. The use of mitochondria to serve as a biomarker is rapidly expanding in disciplines ranging from cancer, rare metabolic diseases, aging, the tracing of human

NMR Analysis of Rhodopsin-Transducin Interactions

December 1, 2006
Author(s)
Kevin Ridge, John Marino, T Ngo, Eva Ramon, D M. Brabazon, N G. Abdulaev
Heterotrimeric G-protein activation by an agonist-stimulated G-protein coupled receptor (R*) requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide-binding pocket. Employing high-resolution NMR

Determination of Lipid Phase Transition Temperatures in Hybrid Bilayer Membranes

September 9, 2006
Author(s)
Neil A. Anderson, Lee J. Richter, John C. Stephenson, Kimberly A. Briggman
The main gel to liquid crystal (LC) phase transition temperature, Tm, of the lipid monolayers in hybrid bilayer membranes (HBMs) was investigated using vibrational sum frequency spectroscopy (VSFS). The unique sensitivity of VSFS to probe order/disorder

HLPR Chair* - A Service Robot for the Healthcare Industry

September 1, 2006
Author(s)
Roger V. Bostelman, James S. Albus
The National Institute of Standards and Technology (NIST) Intelligent Systems Division (ISD) has been working on a healthcare mobility system capable of mobilizing wheelchair dependents, providing patient lift and even rehabilitation. Targeted at the aging

Automated Generation of AnIML Documents by Analytical Instruments

August 1, 2006
Author(s)
Alexander Roth, Ronny Jopp, R Schaefer, Gary W. Kramer
The scope of this project covers the storing of result data produced by generic laboratory devices during processing of analytical experiments, together with the data describing the examination methods and the audit trail using the AnIML (Analytical

Standards in Gene Expression Microarray Experiments

August 1, 2006
Author(s)
Marc L. Salit
The use of standards in gene expression measurements with DNA microarrays is ubiquitous—they just are not yet the kind of standards that have yielded microarray gene expression profiles that can be readily compared across different studies and different

The Pseudo-mitochondrial Genome Influences Mistakes in Heteroplasmy Interpretation

July 21, 2006
Author(s)
Ryan L. Parr, Jennifer Maki, Brian Reguly, Gabriel D. Dakubo, A A. Aguirre, Roy Wittock, Kerry Robinson, J P. Jakupciak, Robert E. Thayer
Nuclear mitochondrial pseudogenes (numts) are a potential source of contamination during mitochondrial DNA PCR amplification. This paper is the first to fully sequence 29 paralogous nuclear DNA fragments that represent the entire mitochondrial genome. This
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