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Bioscience

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Displaying 901 - 925 of 1242

Standards and Standardization of Molecular Diagnostics

August 15, 2005
Author(s)
J P. Jakupciak, C D. O'Connell
DNA has become a major target for clinical laboratory testing over the past 5 years, and RNA testing is emerging for infectious disease and gene expression (1). To normalize laboratory results across different technology platforms as well as between

Mitochondrial DNA as a cancer biomarker

May 1, 2005
Author(s)
J P. Jakupciak, W. Wang, Maura E. Markowitz, D Ally, Michael D. Coble, Sudhir Srivastava, A Maitra, Peter E. Barker, David Sidransky, Catherine D. O'Connell

Standards for Validation of Cancer Biomarkers

April 2, 2005
Author(s)
Catherine D. O'Connell, Donald H. Atha, J P. Jakupciak
Over the past 10 years, DNA testing to identify disease associated mutations and specific organisms, which represent public health and safety concerns, have become major targets for laboratory testing. RNA testing is also emerging for gene expression, both

Infrared and Raman Spectroscopy Characterization of Biological Products

January 1, 2005
Author(s)
Vytautas Reipa
Both infrared and Raman are increasingly applied in biomolecular structure characterization, thus getting acceptance alongside traditional bioanalytical techniques. Physical principles and biological sampling requirements are reviewed. Advanced

Oxidative DNA Damage: Induction, Repair and Significance

September 1, 2004
Author(s)
M D. Evans, Miral M. Dizdar, M S. Cooke
The generation of reactive oxygen species may be both beneficial to cells, performing a function in inter- and intra-cellular signaling, and detrimental, modifying cellular bimolecules, accumulation of which has been associated with numerous diseases. Of

Reversible Proton Transfer Dynamics in Bacteriorhodopsin

August 20, 2004
Author(s)
Y. S. Lee, Morris Krauss
Proton transfer in bacteriorhodopsin from the cytoplasm to the extracellular side is initiated from protonated asp96 in the cytoplasmic region towards the deprotonated Schiff base. This occurs in the transition from the photocycle late M state to the N

Analytical Validation of Telomerase Activity for Cancer Early Detection: TRAP/PCR-CE and hTERT mRNA Quantification Assay for High-Throughput Screening of Tumor Cells

August 1, 2004
Author(s)
J P. Jakupciak, Wenhua Wang, Peter E. Barker, S Srivastava, Donald H. Atha
Activation of telomerase plays a critical role in unlimited proliferation and immortalization of cells. Telomerase activity has been shown to correlate with tumor progression, indicating that tumors expressing this enzyme posses aggressive clinical

Epidemiology of Cancer: An Overview

July 26, 2004
Author(s)
H Rodriguez, D Case
Epidemiology is the study of how often diseases occur in different groups of people and why. Epidemiological information is used to plan and evaluate strategies to prevent illness and as a guide to the management of patients in whom disease has already
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