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Bioscience

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Displaying 926 - 950 of 1250

Oxidative DNA Damage: Induction, Repair and Significance

September 1, 2004
Author(s)
M D. Evans, Miral M. Dizdar, M S. Cooke
The generation of reactive oxygen species may be both beneficial to cells, performing a function in inter- and intra-cellular signaling, and detrimental, modifying cellular bimolecules, accumulation of which has been associated with numerous diseases. Of

Reversible Proton Transfer Dynamics in Bacteriorhodopsin

August 20, 2004
Author(s)
Y. S. Lee, Morris Krauss
Proton transfer in bacteriorhodopsin from the cytoplasm to the extracellular side is initiated from protonated asp96 in the cytoplasmic region towards the deprotonated Schiff base. This occurs in the transition from the photocycle late M state to the N

Analytical Validation of Telomerase Activity for Cancer Early Detection: TRAP/PCR-CE and hTERT mRNA Quantification Assay for High-Throughput Screening of Tumor Cells

August 1, 2004
Author(s)
J P. Jakupciak, Wenhua Wang, Peter E. Barker, S Srivastava, Donald H. Atha
Activation of telomerase plays a critical role in unlimited proliferation and immortalization of cells. Telomerase activity has been shown to correlate with tumor progression, indicating that tumors expressing this enzyme posses aggressive clinical

Epidemiology of Cancer: An Overview

July 26, 2004
Author(s)
H Rodriguez, D Case
Epidemiology is the study of how often diseases occur in different groups of people and why. Epidemiological information is used to plan and evaluate strategies to prevent illness and as a guide to the management of patients in whom disease has already

Local and Global Control Mechanisms in Allosteric Threonine Deaminase

June 1, 2004
Author(s)
David T. Gallagher, D Chinchilla, Herbert Lau, Edward Eisenstein
Allosteric and cooperative control signals were investigated in the tetrameric enzyme threonine deaminase. The tetramer consists of two dimers that associate at the x dyad. The structure pointed the way to use the Q175E mutation to create hybrid tetramers

Data Standards for Proteomics: Mitochondrial Two-Dimensional Polyacrylamide Gel Electrophoresis Data as a Model System

May 1, 2004
Author(s)
Veerasamy Ravichandran, G B. Vasquez, S Srivastava, M Verma, E Petricoin, Joshua Lubell, Ram D. Sriram, Peter E. Barker, G L. Gilliland
The advent of human proteomics as a major discipline has led to a reexamination of the need for consensus and a nationally sanctioned set of proteomics technology standards. Such standards for databases and data reporting may be applied to Two-Dimensional

Structure and Reaction in the Active Site of Mammalian Adenylyl Cyclase

April 8, 2004
Author(s)
Y. S. Lee, Morris Krauss
The reaction path for the catalytic conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) by the enzyme mammalian adenylyl cyclase has been calculated theoretically using the Hartree-Fock method. The crystal structure of a

Multiplexed Assays for Evaluation of Y-SNP Markers in U.S. Populations

April 1, 2004
Author(s)
Peter Vallone, John Butler
Genetic markers located on the Y chromosome are of increasing importance in human identity testing. In an effort to evaluate the forensic utility of Y chromosome single nucleotide polymorphism (SNP) markers, we constructed several novel multiplex allele

Crystal Structure of the Complex Between Thrombin and the Central "E" Region of Fibrin

March 2, 2004
Author(s)
I Pechik, J Madrazo, M W. Mosesson, I Hernandez, G L. Gilliland, L Medved
Non-substrate interactions of thrombin with fibrin play an important role in modulating its procoagulant activity. To establish the structural basis for these interactions, we crystallized PPACK-inhibited thrombin in complex with a fragment, Eht

Dynamics of Proton Transfer in Bacteriorhodopsin

February 25, 2004
Author(s)
Y. S. Lee, Morris Krauss
Proton transfer from the cyctoplasm to the extracellular side is initiated from protonated asp96 in the cytoplasmic region towards the deprotonated Schiff base. This occurs in the transition from the late M photocycle state to the N state. A quantum
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