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Bioscience

Metabolomics

Projects/Programs

Displaying 1 - 18 of 18
diagram of lab information management system

Advanced Fluid Characterization - Laboratory Information Management System

Ongoing
Breath sampling of cannabis users. In July 2019, the National Institute of Justice awarded our team funding for a three-year project to provide the chemical foundation for industry to develop a cannabis breathalyzer. We are developing new experimental methods to enhance the clinical, thermodynamic
Hexagon containing words “environmental metabolomics” with arrows pointing from the hexagon to each of the following images: coral, shrimp, mussel, microbe, horseshoe crab, plant. The circle figure has waves and a tree faded in the background.

Applications in Metabolomics

Ongoing
The application of metabolomics techniques to systems biology reveals insights into model and non-model organism biology. The natural world contains undiscovered chemicals and mechanisms that can be harnessed by industry to create new biomanufacturing processes and products. Each biological system
Cannabis Buds

Chemical Foundations for a Cannabis Breathalyzer

Ongoing
NIST's initial work in cannabis science was a series of measurements of the vapor pressure of two important cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Our current effort is funded in part by interagency agreements with the National Institute of Justice and by the NIST

Combating Antibiotic Resistance

Ongoing
We are developing in vitro systems to generate controlled chemical and community environments that mimic the features of real-world that are important determinants for evolutionary rate and resistance potential. In addition, we are developing tools to isolate and analyze single bacteria along the
component 1

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing
‘Omics is increasingly moving out of the laboratory and towards use in industrial and commercial applications. For instance, in biomanufacturing, there is a need for quality control when developing biotherapeutics, which will almost certainly require a machine-learning classifier to separate
GutMicrobiome

Gut Microbiome Metabolomics Interlaboratory Program

Ongoing
On behalf of the Biosystems and Biomaterials and Chemical Sciences Divisions at the National Institute of Standards and Technology (NIST), we would like to thank you for your interest in our new Gut Microbiome Metabolomics Program. As part of the larger NIST Microbiome Program, this metabolomics
A white box labeled "8048 Human Fecal Material" lies open, with a tray of four plastic vials pulled out.

Human Gut Microbiome Reference Material

Ongoing
The most common measurements currently being used to describe these complex microbial communities are: NGS-based metagenomics Mass spectrometry-based metabolomics In either case, no fit-for-purpose standards exist that enable researchers to compare results generated across different laboratories and
MANTA Logo

Method Assessment for Non-Targeted Analyses (MANTA) Program

Ongoing
Typical targeted analysis aims to detect and/or quantify a set of known chemical compounds using specific instrumental techniques (such as liquid chromatography with triple quadrupole mass spectrometry). In contrast, non-targeted analysis is an analytical technique that detects, identifies, and/or
Figure showing four components of metabolomics with samples and processing

Microbial Metabolomics

Ongoing
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy are widely used and complementary analytical platforms for the characterization, identification, and quantification of a metabolome. MS techniques, typically coupled to chromatography, provide a chemical fingerprint of complex
Graphic of a erlenmeyer flask containing tilled soil, a green leaf, and yellow wheat.

Molecular Innovation in Agriculture

Ongoing
Plant science and breeding aim to develop new plant phenotypes with desired qualities, increased production, disease resistance, and traits that reduce water usage. At the federal level, plant research is conducted by the USDA's Animal and Plant Health Inspection Service (APHIS) and Agricultural
NIST Biorepository Freezers

The NIST Biorepository

Ongoing
The NBSB was established in 1979 at NIST in Gaithersburg, MD with a pilot project archiving human liver samples associated with collections through the Environmental Protection Agency (EPA). New collaborations and banking projects were established including the National Oceanic and Atmospheric
Microbial Strain

NIST Microbial Strain Collection

Ongoing
Microorganisms of interest include but are not limited to those relevant to: biomanufacturing of advanced therapy products; rapid microbial testing; microbial therapeutics (e.g., live biotherapeutic products, probiotics, and fecal microbiota transplantations (FMTs)); infectious disease
Fish on a ruler to measure length, about 47 cm from head to tail.

Omics Technological Advances in Aquaculture

Ongoing
According to the NOAA Fisheries of the U.S. report, in 2020 U.S. seafood consumption was estimated at ~6B pounds (~2.7 x 109 kg). Of that, 85% is imported and U.S. exports have seen a significant decline. Globally, the U.S. ranked only 18th in aquaculture production (2020). NIST aims to enhance the
Breathalyzer

Standards Development to Ensure Reliable Breath Analysis in the Field

Ongoing
Numerous volatile organic compounds (VOCs) have been identified in human breath. These compounds can be produced by the body or by organisms in the body (e.g., bacteria or viruses) and provide a non-invasive window into human health. Inexpensive point-of-care devices are being developed to diagnose
Steroid Hormone Pathway Mapping

Steroid Hormone Suite Analysis

Ongoing
Steroid hormones are signaling molecules that are major regulators of development, reproduction, stress, and growth. Steroids are synthesized from cholesterol through a series of enzymes, resulting in hormones with distinct biological activities. Although hormones are similar in structure, and
Research Grade Testing Material (RGTM 10212), Synthetic Fecal Metabolite Calibrant (Credit: NIST)

Synthetic Fecal Metabolite Calibrant Solution (RGTM 10212)

Ongoing
Metabolomics is an exciting and dynamic field in life sciences that harnesses cutting-edge technologies to identify and characterize small molecules, or metabolites, within cells, tissues, or organisms, collectively known as the metabolome. The wealth of evidence in the literature underscores the
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