Projects/Programs

Displaying 1 - 25 of 203

RM 8376 Microbial Pathogen DNA Standards for Detection and Identification

Ongoing

RM 8376 consists of 20 individual gDNA components from 19 bacterial strains and 1 human reference genome. Its purpose is to enable developers and regulators to evaluate the analytical performance of metagenomic next generation sequencing (mNGS) tools. The material is certified for chromosomal copy

AC-DC Difference

Ongoing

The use of thermal converters for ac voltage metrology was introduced by Frank Hermach at NIST in 1952. The basic thermal converter is a thermoelement, consisting of a thermocouple positioned at the midpoint of a heater wire, enclosed in an evacuated bulb. The thermoelement senses the heat generated

Photograph of a labeled amber bottle containing SRM 2429.

Activated Carbon and FGD Gypsum Standard Reference Materials

Completed

The role of mercury in the environment is now receiving close scrutiny because ultimately it can bioaccumulate as alkyl mercury in seafood with subsequent risk to human health through trophic transfer. Many industrial sources of mercury have been effectively reduced in recent years, but atmospheric

Additive Manufacturing Part Qualification

Completed

Objective To develop and deploy test methods and protocols, standard test artifacts, exemplar data, data processing tools, and automation tools that create robust post-process measurements and non-destructive testing to enable qualification of AM parts by manufacturers. What is the Problem? To

ANSI/NIST-ITL Standard

Ongoing

Recent Announcements Update - Save the Date: NIST welcomes your participation in the ANSI/NIST-ITL virtual workshop on August 25-29, 2025 to update the ANSI/NIST-ITL standard. Registration is required, participant logistics and additional information is available here. Historical Information

ASTM Committee F45 on Driverless Automatic Guided Industrial Vehicles

Ongoing

This website has moved.

Augmented Intelligence for Manufacturing Systems (AIMS)

Ongoing

Objective To overcome existing measurement challenges via augmented intelligence, the fusion of integrated metrology, physics-based models, and artificial intelligence, to enable monitoring, diagnostics, and prognostics of manufacturing systems and their processes. Technical Idea One research

Operating Envelope Specification supports automated driving safety measurement, key to testing and public acceptance of automated vehicles

Automated Vehicles and AV Communications

Ongoing

Automated vehicles (AVs), or Automated Driving Systems-equipped (ADS-equipped) vehicles, have great potential to improve our lives by freeing us from the stress of driving and reducing accidents caused by distractions or poor judgement. Connected, reliable, and safe AVs will spark significant

Basic Metrology (Archive): New Standardization of Ra-228

Completed

Radium-228 has a half-life of (5.75 years) and decays by emitting a beta particle. It is a radioactive decay product in the thorium-232 decay series, a very difficult and complex decay chain: 232Th→ 228Ra → 228Ac → 228Th → 224Ra → 220Rn → 216Po → 212Pb → 212Bi → 208Tl → 208Pb(stable); with a sub

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Basic Metrology: Design and Construction of a New Cs-137 Gamma-ray Calibration Facility

Completed

The new facility was built from the ground up, starting with an empty room, based on original design specifications developed by the Dosimetry Group at NIST. It is divided into two areas (control and irradiation) that are isolated from each other. The irradiation area contains a new 137Cs gamma-beam

Basic Metrology: Remote Sensing Methods for Imaging Dose to Water

Ongoing

Ultrasound and laser interferometry, widely used for nondestructive testing and remote sensing applications, are being used here to measure dose distributions in irradiated water phantoms by taking advantage of temperature dependence in the speed of sound and optical index of refraction of water

Biofabrication of Tissue Engineered Constructs

Ongoing

OCT imaging was assessed using a model scaffold-cell system consisting of a polysaccharide-based hydrogel seeded with human Jurkat cells. Four test systems were used: hydrogel seeded with live cells, hydrogel seeded with heat-shocked or fixed dead cells and hydrogel without any cells. Time series

Bioprocessing Laboratory

Ongoing

Current Capabilities Computer controlled liquid nitrogen biostorage system Two culture areas including 4 monitored CO2 incubators 2 Six-foot BSLII biosafety cabinets Measurements- cell count and concentration, STR typing, flow cytometry, cell volume size distribution, conventional transmission and

Calibration Service: Absorbed Dose to Water and Air Kerma Calibration in Co60 Therapy Level Gamma Ray Beams

Ongoing

Measurements provided by these accredited dosimetry calibration laboratories (ADCLs) are directly traceable to the national standard for absorbed dose to water and air kerma from 60Co therapy level gamma ray beams held at NIST. This is achieved by the use of high quality ionization chambers that are

Calibration Services: Low-Energy Photon Brachytherapy Sources

Ongoing

Since 1999, over 1,500 seeds of more than 40 different designs from 18 manufacturers have been calibrated using the WAFAC. On-site characterization at seed manufacturing plants for quality control, as well as at therapy clinics for treatment planning, relies on well-ionization chamber measurements

Cancer Biomarker Measurements and Collaborations

Ongoing

Collaborations and Cooperative Research Agreements We welcome collaborations and can help with assay validation and development of reference materials. Below are some examples of our collaborations and ways we can develop test materials. Early Detection Research Network (EDRN): Interagency agreement

Carbon Capture, Use, and Storage

Ongoing

Carbon Capture, Use, and Storage (CCUS) requires a suite of technologies to capture carbon dioxide from industrial point sources, the atmosphere, and the ocean; convert carbon dioxide into products such as fuels, chemical feedstocks, and building materials; and sequester carbon dioxide deep

Image showing a variety of gas tanks with carbon dioxide

Carbon Dioxide Measurements and Reference Materials

Ongoing

CO 2 Reference Materials The Gas Sensing Metrology Group at NIST has a long history of providing reference materials to industry, monitoring communities, and academia. The program began in the 1970’s by developing an initial suite of CO2 primary standard mixtures (PSMs) to support the US Department

Carbon Nanotube Reference Materials

Completed

Carbon nanomaterials are expected to play an important role in future technological developments of transistors, photovoltaics, transparent thin film conductors, sensors, and fuel cell electrodes among many potential applications. However, the potential of these materials has been hindered by a lack

Cell Counting for Cell Therapies

Ongoing

Recent Publications and Resources for Cell Counting and Related Measurements Tools NOW AVAILABLE : COMET (Counting Method Evaluation Tool) , A Shiny Application that executes the statistical analysis and reporting outlined in ISO 20391-2:2019 https://cell-counting.shinyapps.io/COMET/ Standards ISO

Certification of Three Soil SRMs for Inorganic Environmental Measurements

Completed

The three NIST soil SRMs, 2709, 2710 and 2711, have been used worldwide by hundreds of laboratories; combined sales typically exceed 800 units per year. Use of these SRMs provides our customers with tools that are essential for achieving quality assurance in the analysis of contaminant elements in

Charpy Machine Verification Program

Ongoing

Impact testing is required for many critical applications in the construction, machinery and equipment, defense, and energy markets. Charpy testing provides data needed to ensure the quality and reliability of structural steel products. Approximately 1,300 machines per year are evaluated for

Photograph of titanium metal crystal with cubic symmetry.

Chemical Metrology for Metals, Ores, and Related Materials

Ongoing

In the arena of industrial commodities, the primary challenges are to provide measurement tools and reference materials that allow U.S. industry to establish comparability of measurement results to results obtained by customers, competitors, and regulators for the basic chemical properties of

Chemical Metrology for Polymers Manufacturing

Ongoing

This project is designed to strengthen the analytical capabilities of polymers manufacturers by introducing reference materials, critically evaluating standard test methods, and educating those industry representatives who participate in standards development organizations. Certified reference

Circular Economy Closed Loop Recovery

Ongoing

Objective To define critical material and information pathways to support the development of closed-loop systems to establish reliable sources of secondary material feedstocks that divert critical resources away from landfills using material recovery strategies - recycling, remanufacturing, and

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