Projects/Programs

Displaying 1 - 25 of 156

AAPS Interlaboratory Study: Protein Aggregation and Immunogenicity

Ongoing

To ensure the safety and efficacy of protein-based biotherapeutics, manufacturers strive to avoid unwanted immune responses caused by the biotherapeutic. Protein immunogenicity is a complex topic and depends on multiple factors related to the product, patient profile, and treatment. 1 , 2

Accelerated Weathering Laboratory: Metrology and Technology Transfer

Ongoing

Objective By 2027, validate and implement the NIST Accelerated Weathering Laboratory (AWL) technology for conducting accurate and traceable aging experiments. By 2028, transfer the SPHERE technology to industrial stakeholders. Technical Idea A NIST Accelerated Weathering Laboratory (AWL) has been

EBSD grain orientation map for additively manufactured Ti-6Al-4V showing elongated prior-Beta grain morphology in the build direction (vertical in this image)"

Additive Manufacturing Fatigue and Fracture

Ongoing

RESEARCH HIGHLIGHTS FACILITIES and CAPABILITIES PUBLICATIONS - see individual staff webpages on right POST-DOCTORAL OPPORTUNITIES - jump to section below Metal additive manufacturing (AM) is not used in fatigue and fracture critical applications despite industrial need. The goal of this project is

Advanced Cements and Concretes Consortium

Concrete, the predominant construction material, is used globally due to its properties such as strength, workability, elasticity, and durability and materials availability. To reduce costs, increase local sourcing, and ensure supply chain security, new strategies are being developed including the

Advanced Composites Pilot for the Materials Genome Initiative

Completed

Many computational programs exist that are being used by industry for predicting properties of polymer composites but their general predictive power is limited by how faithfully the microstructure is represented and how realistically the interfaces are handled. The computations are limited by the

Advanced Materials: Elemental and Chemical Analysis of Microstructured Materials

Ongoing

Projects: DTSA-II – Pushing the Limits of Energy Dispersive X-ray Spectrometry Multimodal Superresolution Microscopy Forensic Trace Evidence

Advanced Materials Metrology

Ongoing

Electromagnetic devices cannot operate without the interaction of electromagnetic waves with materials, and the characterization of the interface between fields and materials will be a critical task for any device or metrology development from nanoscale to larger scales. Areas of impact over the

Advanced Materials: X-ray Science for Standards and Analysis

Ongoing

Projects: Theoretical Calculations of Near-Edge X-ray Spectra Microcalorimeter X-ray Detector X-ray Spectroscopy and Electronic Structure of Solids X-ray Methods for Chemical Imaging at Micro to Mesoscales

Advanced Microscopy for Trace and Bulk Particle Characterization

Ongoing

The goal of this project is to help develop innovative metrologies and measurement protocols for micro/nano-scale analysis of particles. In this project, state-of-the-art optical and electron-based microscopy are used to conduct research for quantitative and qualitative analysis of chemical

Aerodynamic Flow Visualization

Ongoing

Other videos: How Well Do Masks Work? (Schlieren Imaging In Slow Motion!) 3 Ways Of Seeing Invisible Air Flow (Veritasium) The Air You Share | All in This Together Publications "Filter Inserts Impact Cloth Mask Performance against Nano- to Micro-Sized Particles" James G. Radney, Jamie L. Weaver

Micrographs of kinetic inductance-based parametric amplifier

Amplifiers

Ongoing

We have developed parametric amplifiers based on two different technologies: Josephson Junctions and superconductors with high kinetic inductance, a representation of the kinetic energy of superconducting Cooper-pair charge carriers. Junction-based parametric amplifiers (JPAs) are well suited for

$Four examples of Transmission electron diffraction patterns obtained in a scanning electron microscope.$

Analytical Scanning Transmission Electron Microscopy in a Scanning Electron Microscope (STEM-in-SEM)

Ongoing

Conventional transmission electron imaging does not necessarily show both strong contrast and high spatial resolution for nanomaterials or soft matter. This is particularly the case for isolated nanostructures or low- Z materials like polymers or biomaterials. For example, consider structures in the

Annual Machine Learning for Materials Research Bootcamp

Ongoing

Four days of lectures and hands-on exercises covering a range of data analysis topics from introduction to python and data pre-processing to advanced machine learning analysis techniques. Example topics include: Identifying important features in complex/high dimensional data Visualizing high

Assessing Pyrrhotite in Concrete

Ongoing

Objective Develop a standard test method and a set of calibration reference materials to quantify pyrrhotite in concrete; document pyrrhotite/aggregate/concrete reactions and rates so that the most deleterious reactions can be efficiently reduced or eliminated; and evaluate proposed mitigation

Assessment of High-Temperature and Innovative Insulation Thermal Performance

Ongoing

Objective To improve residential and industrial building energy efficiency by decreasing measurement uncertainties of the thermal resistance of insulating materials and develop measurement techniques for innovative insulation materials and systems using PCMs. Technical Idea One of the most cost

Atom Probe Tomography: Nanostructured Semiconductor Materials, Interfaces, and Devices

Ongoing

Atom probe tomography (APT) is a unique analytical tool capable of providing 3D atomic maps of any element in the periodic table with sub-nm spatial resolution and high analytical sensitivity (in the ppm range, in some cases). APT is currently employed by many of the largest semiconductor

Atomistic Potentials and the Future of Nanomaterials Metrology

Ongoing

Atomistic simulations are increasingly being used as a tool to understand and predict properties of materials in systems, such as nanomaterials, where direct measurement is time-consuming or extremely difficult. The success of atomistic simulations depends critically on the fidelity of a specific

Automotive Lightweighting

Ongoing

The US auto industry spends $600M per year fixing and tweaking forming dies that do not make correct parts. The primary reason that the dies are inaccurate is that the computer models of the dies utilize materials models that are inaccurate. Upon surveying our industrial partners, we determined that

Autonomous Scanning Droplet Cell

Ongoing

Corrosion impacts a broad spectrum of application areas including infrastructure, transportation, and the military. The annual price tag for corrosion mitigation and remediation is 3.4 % of the US GDP. The team is particularly interested in discovering new metallic glasses (metals without long range

Autonomous Synthesis of Metal-Organic Frameworks

Ongoing

Metal-organic frameworks (MOFs) show great promise for a variety of applications, from industrial gas separation, to catalysis, to PFAS absorption. One challenge to the adoption of these technologies is determining and optimizing the synthesis of these materials. There are large computational

$Autonomous materials metrology diffraction measurement performed at SLAC$

Autonomous Systems for Materials Research and Metrology: Accelerating Discovery and Democratizing Science

Ongoing

Materials scientists often need to search high dimensional spaces for knowledge. For example, a scientist may be interested in learning how a material property (e.g. hardness) changes over many (for example, 10) values of a synthesis or processing parameter (e.g., annealing temperature). Such an

EV Battery Passport

Completed

End-of-life issues associated with EV batteries (EVBs) are estimated to have a steep rise in the coming decades. Given the finite nature of material resources worldwide, developing a circular EV batteries (EVB) infrastructure is needed to keep high value battery materials in the economy, therefore

Biofabrication of Tissue Engineered Constructs

Ongoing

OCT imaging was assessed using a model scaffold-cell system consisting of a polysaccharide-based hydrogel seeded with human Jurkat cells. Four test systems were used: hydrogel seeded with live cells, hydrogel seeded with heat-shocked or fixed dead cells and hydrogel without any cells. Time series

Bioimaging

Completed

Imaging and image analysis are used ubiquitously in biological and biomedical research. One of the great advantages of imaging is its intuitive information content; much can be learned from just a glance at the data. On the other hand, these data generally contain a very large amount of untapped

Biomaterials for Oral Health

Completed

NIST along with its partners has a long commitment to scientific excellence with demonstrated impact in improving the oral health of the public. NIST researchers are leaders in this field and create a community by engaging other researchers, industry, and regulatory agencies to address urgent needs

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