Projects/Programs

Displaying 1 - 13 of 13

Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program

Ongoing

Comparative proteomics strives to gain insight into key underlying molecular changes that result in unique phenotypes across related taxa. Proteomic analysis complements comparative genomics by providing evidence of protein abundance, orthogonal to gene copy number and amount of transcript. To...

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing

‘Omics is increasingly moving out of the laboratory and towards use in industrial and commercial applications. For instance, in biomanufacturing, there is a need for quality control when developing biotherapeutics, which will almost certainly require a machine-learning classifier to separate...

Figure contains text “Omics Data Quality” and human outline with arrows pointing from the human to the following specimen types: liver, serum, stool, plasma, urine. On either side of the human are analytical spectra and everything is surrounded by a decorative molecule structure circular border.

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

There is a significant need for tools to increase harmonization, comparability, and reproducibility between laboratories and/or studies, and to provide quality control of sample preparation and data analysis protocols utilized in untargeted omics analysis. Reference materials are being developed to...

Mixed nuts in wooden bowls on black stone table.

Harmonization of Allergen Detection and Quantification with NIST Reference Materials

Ongoing

NIST provides food allergen Reference Materials (RMs) for the global food industry. Our work centers on validating the performance of these materials across diverse analytical platforms, specifically liquid chromatography-tandem mass spectrometry (LC-MS/MS) and enzyme-linked immunosorbent assays...

HDX-MS for Biopharmaceutical Analysis

Ongoing

This project is designed to improve, test, and validate hydrogen/deuterium exchange mass spectrometry (HDX-MS) metrology for the determination of dynamical properties of therapeutic proteins and glycoproteins. The research project uses HDX-MS to measure the D-for-H exchange rates of the amide groups...

Human Gut Microbiome Reference Material

Ongoing

The most common measurements currently being used to describe these complex microbial communities are: NGS-based metagenomics Mass spectrometry-based metabolomics In either case, no fit-for-purpose standards exist that enable researchers to compare results generated across different laboratories and...

Metrologies for Protein Structure, Dynamics and Function

Ongoing

Based on its established expertise, infrastructure, and resources for structure/function studies of biological macromolecules, the program aims to impact advances in physics, chemistry, and engineering relevant to biological problems. NIST researchers also develop new technologies for application to...

Monoclonal Antibody Mass Spectral Libraries

Ongoing

Intended Impact Modern mass spectrometers used in the field of proteomics and glycomics are capable of profiling hundreds, and even thousands of molecules in a single experiment. Each of these compounds is isolated and fragmented to form a mass spectrum. Therefore, interpretation of these mass...

NIST Urine Albumin Standardization Program

Ongoing

Kidney Disease – A Global Concern Kidney disease is a significant global public health and economic issue, with Chronic Kidney Disease (CKD) ranking among the top 10 worldwide causes of death. The critical need for early and accurate diagnosis, effective treatment management, and ongoing patient...

NIST26: Updates to the NIST Electron Ionization and Tandem Mass Spectral Libraries

Ongoing

NIST/EPA/NIH EI-MS Library, 2026 release 431,277 electron ionization (EI) spectra 382,180 compounds, 49,097 replicate spectra 35,080 more compounds than the 2023 release 527,993 retention index (RI) values 216,093 compounds measured under a variety of conditions 188,198 compounds with both RI & MS...

Performance Metrics for Proteomics

Completed

Intended Impact Proteomics experiments designed to identify protein markers specific to a particular disease or disease state rely on repeatable identification of proteins within a control set. Repeatability provides statistical assurance that clear differences between two sets (e.g. sick vs...

Standards for Immuno-histochemical Imaging: A Biomarker Protein Expression Chip

Completed

Intended Impact The lack of quantitative imaging methods and reagents impedes the validation of image-based biomarkers. Improved methods for biomarker quantification and an established traceable value assignment would be useful to customers in a wide range of areas that include clinical diagnostics...

Trusted AI framework for a new class of Standard Reference Materials and Data with exquisitely characterized uncertainty for billions of properties

Ongoing

The measurement of diverse molecular classes in biospecimens containing millions of molecules, known as omics, is increasingly important in the life sciences and medicine, and used to find novel cancer therapeutics, discover COVID-19 infection pathways, and diagnose diseases. NIST RMs and SRDs for...

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----Materials and Physical Services Group
---Material Data Division
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----Theory, Modeling, and Simulation Group
----Data Center and Business Group
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---Biosystems and Biomaterials Division
----Biomarker and Genomic Sciences Group
----Cellular Engineering Group
----Biomaterials Group
----Complex Microbial Systems Group
----Cell Systems Science Group
----Biosystems and Biomaterials Division - HQ
---Chemical Sciences Division
----Biochemical and Exposure Science Group
----Optical Measurements Group
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----Gas Sensing Metrology Group
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----Chemical Sciences Division - HQ
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---Biomolecular Measurement Division
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----Thermodynamics Research Center Group
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----Polymers Processing Group
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---Quantum Measurement Division
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----Device Fabrication Group
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