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Bioscience

Engineering / synthetic biology

Projects/Programs

Keyword

Organizational Unit

NIST Workshops on Cell-Free Expression Systems

Ongoing

NIST has co-hosted two cell-free workshops. NIST CELL-FREE (Comparable Engineered Living Lysates For Research Education and Entrepreneurship) Workshop (2019) The NIST CELL-FREE workshop took place in La Jolla, CA in February 2019, in collaboration with the J. Craig Venter Institute (JCVI). The

TOP: Image of fluorescent reference material on microscope. BOTTOM: Charting of microscope control parameters.

Performance Benchmarking and Intensity Calibration of a Widefield Fluorescence Microscope

Ongoing

Widefield fluorescence microscopy is a highly used tool for visually assessing biological samples and for quantifying cell responses. Despite its widespread use in high content analysis and other imaging applications, few published methods exist for evaluating and benchmarking the analytical

Protocols, datasets, and software for engineering biology

Ongoing

Published protocols, datasets, and software for engineering biology from the Cellular Engineering Group. Protocols Romantseva J, Ross D, Alperovich A, Strychalski E, Automated DNA template preparation and quantitation methods, https://www.protocols.io, March 23, 2022, https://dx.doi.org/10.17504

Prototype Cell Assay Measurement Platform (P-CAMP)

Ongoing

A systematic approach to the development of robust biological assay includes identifying and ranking the sources of variability in an assay protocol. With a focus on mammalian cellular assays, the Prototype Cell Assay Measurement Platform ( P-CAMP) laboratory was designed and built to take advantage

RNA Computation and Metrology for Engineering Biology

Ongoing

RNA computation RNA computation, i.e., programmed interactions between RNA molecules that process information, is an increasingly useful synthetic biology tool with applications spanning in vitro biosensing, synthetic cells, and cellular control. We have developed cotranscriptionally encoded RNA

Serology and Neutralization Assays for COVID-19

Ongoing

Multiplexed bead-based SARS-CoV-2 serological assay We have developed a validated multiplexed bead-based SARS-CoV-2 serological assay that measures different antibodies produced by a patient (IgG, IgM, IgA). In collaboration with the NIST Applied and Computational Mathematics Division, we have

Single-Cell Manipulation and Measurement

Ongoing

Mammalian cells are an important source material for applications in regenerative medicine, gene therapy, engineering biology, and genome editing. Traditional tools for manipulating mammalian cells operate at a bulk cell population level without precision manipulation of individual cells

Synthetic Biology

Ongoing

New measurement methods and tools are required for biology to emerge fully as an enabling, practical platform for engineering. The Cellular Engineering Group works to provide a foundation of measurement assurance to support the control and rational design of biological function. Through state of the

Synthetic Biology Standards Consortium (SBSC)

Completed

The SBSC is an open and voluntary consortium consisting of private companies, academic researchers, and public entities convened and hosted by NIST. The objective of the SBSC is to collectively build the metrology infrastructure to support a fully integrated, global synthetic biology enterprise. A

Thermodynamic Principles Describe and Predict Cell Populations

Ongoing

Heterogeneity of cell populations indicates the many ways cells can process information. We study heterogeneity in gene expression by inserting a gene for a fluorescent protein downstream of the gene we are interested in, and we examine large numbers of cells by imaging or flow cytometry. We think

Validating A.I. Pipelines for Analysis of Live Cell Image Data

Ongoing

We are exploring methods for very high-speed cell image data collection, which is enabling the repeated sampling of thousands of cells every 2 minutes. Rapid sampling allow us to observe dynamic processes in cells (such as cell division) on a relevant time scale. Such rates of sampling allows us to

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