Projects/Programs

Displaying 1 - 25 of 149

DARPA Friend or Foe (FoF) -- Independent Verification and Validation (IV&V)

The development of new platforms for characterization of complex microbial samples are hampered by lack of reproducibility and comparability across different

RM 8376 Microbial Pathogen DNA Standards for Detection and Identification

Metagenomic Next Generation Sequencing (mNGS) promises to revolutionize infectious disease diagnostics. However, the analytical performance of this technology

Advanced electron paramagnetic resonance spectroscopy for structural characterization of bionanomaterials for bioscience and biotechnology

Recent advances in nanofabrication and nanobiotechnology rely on biomacromolecules. In biotechnology, biomacromolecules at nanometer length scales are either

Advanced Magnetic Imaging Methods

The scope of MRI is expanding with the development of both ultra-high field (14 T) and ultra-low field (0.1 mT) scanners not only for biomedical applications

Advanced Materials Metrology

In this project we measure the fundamental electrical properties of materials from bulk to nanoscale from 1 MHz to 0.3 THz. Understanding the interaction of

Advanced Spectral Analysis: Two-Dimensional Correlation Spectroscopy

We have developed an approach to characterize overlapping spectral data based on two-dimensional correlation spectroscopy (2DCOS). Using advanced 2DCOS, we

Advanced Therapies Laboratory Programs

The NIST Advanced Therapy laboratory programs are focused on developing innovative measurement assurance solutions and technologies to accelerate translation

Automated Live Cell Imaging for Quantification of Catalytic Rates in Individual Cells

To accurately interpret the data from fluorescent proteins as reporters of gene activation within living cells, it is important to understand the kinetics of

Bioelectronic Sensors for Tissue/Organ-on-a-Chip Systems

The use of tissue/organ-on-a-chip systems is limited to endpoint and destructive measurements. Integration of electronic elements in these systems have proven

Bioimaging

Our goal is to develop methods and materials for imaging-based characterization of molecular signatures that occur during cellular proliferation

Biomanufacturing Initiative

Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The

Biomaterials for Oral Health

Our goal is to enable the development and manufacturing of biomaterials for oral health moving forward in 21st century by providing critical measurement methods

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Broadband Coherent Anti-Stokes Raman Scattering (BCARS) Microscopy

The traditional chemical labeling used in optical microscopy can alter cells and materials, thus impeding determination of their true structure, function and

Building Measurement Confidence for Cell Characterization

Cells are being used in drug discovery, therapeutics development, biomedical research, and biotechnological and medical applications. However, the measurement

Cancer Biomarker Reference Materials

NIST develops reference materials for cancer biomarkers that can be used to improve measurements of assays used in basic research and in clinical applications

Cardiac Device Reliability

The growing sophistication of electronic medical devices results in two broad benefits for both individuals and society: improved survivability in the face of

Cell Counting for Cell Therapies

Counting is a simple concept that we grasp at an early age, yet counting the number of cells accurately and reproducibly for cell-based biotechnology has been

Cell Line Authentication

Cells derived from different organisms and tissues have been established and are used in bioresearch and for the production of complex biological products. The

Cell-based Assay for Mechanistically-based Prediction of Cytoxicity

The most commonly used cell-based assays for measuring cytotoxicity often show poor reproducibility, require 24 h to complete, and rely on a nonspecific

Certification of Standard Reference Material 2393 for the CAG repeats of Huntington Disease

Huntington disease is a neurodegenerative disease of midlife onset that produces choreic movements and cognitive decline, often accompanied by psychiatric

Certification of a Standard Reference Material for Cytomegalovirus (CMV)

**Update**As of September 1, 2015 SRM 2366a Cytomegalovirus DNA (TowneΔ147 BAC) for DNA Measurements was made available. The new material is a single component

Characterization of Dolphin Lung Endothelial Cells Through Quantitative Imaging

A collaboration between the Medical University of South Carolina (MUSC), Hollings Marine Laboratory, and NIST is examining the relationship between cell

Chinese hamster ovary (CHO) cell line authentication

The misidentification of cell lines has been a problem in the scientific community for the past 50 years. Methods are now in place to genotype human cell lines

Combating Antibiotic Resistance

A Paradigm Shift in Addressing Antimicrobial Resistance: Measuring the Transition Between Antibiotic Susceptibility and Resistance With the exception of our own

Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program

NIST is developing a portal to enable researchers to mine high-quality proteomic data from phylogenetically diverse species, to identify advantageous biological

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