Projects/Programs

Displaying 1 - 25 of 176

RM 8376 Microbial Pathogen DNA Standards for Detection and Identification

Ongoing

Metagenomic Next Generation Sequencing (mNGS) promises to revolutionize infectious disease diagnostics. However, the analytical performance of this technology

AAPS Interlaboratory Study: Protein Aggregation and Immunogenicity

Ongoing

The National Institute of Standards and Technology, in collaboration with the American Association of Pharmaceutical Scientists (AAPS), is coordinating an

Advanced electron paramagnetic resonance spectroscopy for structural characterization of bionanomaterials for bioscience and biotechnology

Ongoing

Recent advances in nanofabrication and nanobiotechnology rely on biomacromolecules. In biotechnology, biomacromolecules at nanometer length scales are either

Advanced Magnetic Imaging

Ongoing

The scope of MRI is expanding with the development of both ultra-high field (14 T) and ultra-low field (0.1 mT) scanners not only for biomedical applications

Advanced Materials Metrology

Ongoing

In this project we measure the fundamental electrical properties of materials from bulk to nanoscale from 1 MHz to 0.3 THz. Understanding the interaction of

Advanced Spectral Analysis: Two-Dimensional Correlation Spectroscopy (2DCOS)

Ongoing

We have advanced a spectral analysis method to characterize overlapping spectral data based on two-dimensional correlation spectroscopy (2DCOS). Using advanced

Automated Live Cell Imaging for Quantification of Catalytic Rates in Individual Cells

Ongoing

To accurately interpret the data from fluorescent proteins as reporters of gene activation within living cells, it is important to understand the kinetics of

Bioelectronic Sensors for Tissue/Organ-on-a-Chip Systems

Ongoing

The use of tissue/organ-on-a-chip systems is limited to endpoint and destructive measurements. Integration of electronic elements in these systems have proven

Bioimaging

Ongoing

Our goal is to develop methods and materials for imaging-based characterization of molecular signatures that occur during cellular proliferation

Biomanufacturing Initiative

Ongoing

Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The

Biomaterials for Oral Health

Ongoing

Our goal is to enable the development and manufacturing of biomaterials for oral health moving forward in 21st century by providing critical measurement methods

Bioprocessing Laboratory

Ongoing

The new bioprocessing laboratory adds capability to model industrialized processes used for expanding cellular materials. Staff can leverage this state-of-the

Broadband Coherent Anti-Stokes Raman Scattering (BCARS) Microscopy

Ongoing

Broadband coherent anti-Stokes scattering (BCARS) microscopy is an imaging modality that probes the chemical content and abundance of samples without the

Building Measurement Confidence for Cell Characterization

Ongoing

Cells are being used in drug discovery, therapeutics development, biomedical research, and biotechnological and medical applications. However, the measurement

Cancer Biomarker Measurements and Collaborations

Ongoing

NIST develops cancer measurements by working with our stakeholders to deliver improved measurement methods, data, test materials, interlaboratory testing

Cardiac Device Reliability

Ongoing

The growing sophistication of electronic medical devices results in two broad benefits for both individuals and society: improved survivability in the face of

Cell Counting for Cell Therapies

Ongoing

Cell counting (or cell enumeration) is one of the most fundamental measurements in biotechnology, from biomanufacturing to medical diagnosis to advanced therapy

Cell Line Authentication

Ongoing

Cells derived from different organisms and tissues have been established and are used in bioresearch and for the production of complex biological products. The

Cell-based Assay for Mechanistically-based Prediction of Cytoxicity

Ongoing

The most commonly used cell-based assays for measuring cytotoxicity often show poor reproducibility, require 24 h to complete, and rely on a nonspecific

Certification of a Standard Reference Material for Cytomegalovirus (CMV)

Ongoing

**Update** As of September 1, 2015, SRM 2366a Cytomegalovirus DNA (TowneΔ147 BAC) for DNA Measurements was made available. The new material is a single

Certification of Standard Reference Material 2393 for the CAG repeats of Huntington Disease

Ongoing

Huntington disease is a neurodegenerative disease of midlife onset that produces choreic movements and cognitive decline, often accompanied by psychiatric

Characterization of Dolphin Lung Endothelial Cells Through Quantitative Imaging

Completed

A collaboration between the Medical University of South Carolina (MUSC), Hollings Marine Laboratory, and NIST is examining the relationship between cell

Chinese hamster ovary (CHO) cell line authentication

Ongoing

The misidentification of cell lines has been a problem in the scientific community for the past 50 years. Methods are now in place to genotype human cell lines

Combating Antibiotic Resistance

Ongoing

A Paradigm Shift in Addressing Antimicrobial Resistance: Measuring the Transition Between Antibiotic Susceptibility and Resistance With the exception of our own

Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program

Ongoing

NIST is developing a portal to enable researchers to mine high-quality proteomic data from phylogenetically diverse species, to identify advantageous biological

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