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Material Measurement Laboratory

Projects/Programs

Displaying 376 - 400 of 569
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NIST Ocean Carbon Measurements

Ongoing
NIST is committed to sustaining the quality of ocean carbon measurements by developing capabilities to provide certified reference materials for the ocean carbonate system measurements and by conducting research to understand fundamental elements of the ocean carbon thermodynamic system. NIST Ocean
Map of the Hawaiian islands showing outlines and major cities of the islands.

NIST U.S. Pacific Islands Program

Completed
To help address environmental research and resource management in the Pacific Islands region, the 111th U.S. Congress directed NIST to "expand its capabilities and resources into the Pacific region through a Pacific Islands component of NIST" and included funding to "expand its biodiversity storage
NIST PS1

NIST PS1 Primary Standard for quantitative NMR (Benzoic Acid)

Completed
With explicit SI linkage, the overall impact of this apical reference material is profound—this primary standard, as well as forthcoming members of its class, provides technology transfer of chemical purity realization to the commercial sector for characterization of many thousands of organic

NIST Rapid Microbial Testing Methods Consortium

Ongoing
The safety and quality of advanced therapies, including cell therapy, gene therapy, and tissue engineered products, must be maintained prior to patient administration. The culture-based compendial methods currently used to assess product purity (specifically to ensure absence of microbial
Photograph of the NIST Standard Reference Photometer showing the component modules consisting of optical bench with sample and reference tubes, ozone generator module with controls and tubing, and control module with numeric LED displays.

The NIST Standard Reference Photometer for Ozone Measurement Traceability

Ongoing
The concentration of ozone in the atmosphere continues to be an important global issue both scientifically and politically. Stratospheric ozone protects the Earth from harmful UV radiation, while tropospheric ozoneis a major health concern and contributes to global climate change as a greenhouse gas
Evolution of Flat-histogram Monte Carlo Simulation

NIST Standard Reference Simulation Website

Ongoing
Molecular simulations, in particular Monte Carlo Molecular Simulation and Molecular Dynamics Simulation, are methods for computing the properties of some kind of system, for which the intermolecular interactions are specified via mathematical relationships derived from statistical mechanics. Since
Image of a fentanyl mass spectrum shown in a lab notebook

NIST and the SWGDRUG Mass Spectral Reference Library of Seized Drugs

Ongoing
Synthetic drugs such as fentanyl and its analogues are driving an unprecedented epidemic of overdose deaths in the United States. Clandestine labs create these new substances in part to evade law enforcement. This places a major burden on federal, state, and local law enforcement agencies to
Cannabis

NIST Tools for Cannabis Laboratory Quality Assurance

Ongoing
Since the 1970s, cannabis (marijuana and hemp) and its constituent, Δ 9-tetrahydrocannabinol or THC, have been classified as Schedule I controlled substances. Seized evidence is tested by forensic laboratories, which verify the identity of the plant through macro- and microscopic evaluation and the
Photograph of hundreds of gas cylinders in a gas storage facility.

NIST Traceable Reference Material Program for Gas Standards

Ongoing
The Gas Mixture SRM, NTRM, and EPA Protocol Programs provide a mechanism to produce needed calibration gas standards with a well-defined traceability. These mixtures are specified in the Code of Federal Regulations (CFR) to calibrate instruments to be used to monitor regulated emissions. The NTRM
Reference Measurement System for Urine Albumin

NIST Urine Albumin Standardization Program

Ongoing
Kidney disease is a major global economic and public health issue, with chronic kidney disease (CKD) representing one of the top 10 most prominent causes of death worldwide. The public health and economic impact of CKD and other kidney diseases has led to the need for the accurate detection of
Test tube illustrating NIST cell-free workshop topics

NIST Workshops on Cell-Free Expression Systems

Completed
NIST has co-hosted two cell-free workshops. NIST CELL-FREE (Comparable Engineered Living Lysates For Research Education and Entrepreneurship) Workshop (2019) The NIST CELL-FREE workshop took place in La Jolla, CA in February 2019, in collaboration with the J. Craig Venter Institute (JCVI). The
Box for NISTCHO in center, vial of NISTCHO to the right

NISTCHO

Ongoing
NISTCHO, a new mammalian cell line of interest to the biopharmaceutical and biomanufacturing communities, is now available from the National Institute of Standards and Technology. This Chinese hamster ovary (CHO) cell line has been engineered by MilliporeSigma to express a non-originator version of
NPS Data Hub

Novel Psychoactive Substance (NPS) Data Hub

Ongoing
A growing portion of forensic drug laboratory’s workload is the identification of novel psychoactive substances (NPSs), or emerging synthetic drugs (ESDs), presented as exhibit materials after seizure events. A pressing need exists for the rapid characterization of both the active ingredient(s) and
OOF3D Logo

Object Oriented Finite Elements (OOF)

Ongoing
The best and most current information about the OOF software, including current downloads, can be found at the main OOF site. The general workflow of the OOF software begins with a 2D or 3D image. OOF provides tools for maniupating the image to highlight scientifically important features, and to
Fish on a ruler to measure length, about 47 cm from head to tail.

Omics Technological Advances in Aquaculture

Ongoing
According to the NOAA Fisheries of the U.S. report, in 2020 U.S. seafood consumption was estimated at ~6B pounds (~2.7 x 109 kg). Of that, 85% is imported and U.S. exports have seen a significant decline. Globally, the U.S. ranked only 18th in aquaculture production (2020). NIST aims to enhance the

Ontologies and Interoperability in Evolutionary Comparative Analysis

Completed
Intended impact Nearly all scientists who regularly use online resources on genes, proteins and genomes make use of comparative data to advance biomedical research. For instance, researchers often make useful inferences by comparing human genes (as well as proteins, reactions, interactions, pathways

OOF

Ongoing
The OOF project is a software development project designed to make advanced computational modeling capabilities available to materials science researchers who are not themselves computational experts. Researchers bring domain expertise from materials science to assist in building high-quality finite
Open CALPHAD Logo

OpenCALPHAD

Ongoing
Thermodynamic data are essential for the understanding, developing, and processing of materials. The CALPHAD technique has made it possible to calculate properties of multicomponent systems using databases of thermodynamic descriptions with models that were assessed from experimental data. The OC
fentanyl

Opioid Detection and Identification

Ongoing
Safe Handling Fentanyl can be 100 times stronger than heroin. Even deadly street drugs contain very small amounts of fentanyl, so it can be difficult to detect with methods used for other common drugs. NIST researchers developed a method sensitive enough to detect fentanyl on the outside of drug
schematic

Optical/electrical particle measurement system

Ongoing
Intended Impact The results of this work should provide instrument manufacturers with data, methods, and algorithms for enhancing the clarity and accuracy of information their instruments provide to their customers. Users of these instruments (pharma companies) and regulators, will have better
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