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Material Measurement Laboratory

Projects/Programs

Displaying 301 - 325 of 568
Photo of the magnetic moment and susceptibility SRMs - platinum cylinder, YIG sphere, Ni sphere, and Ni disk.

Metrology of Magnetic Materials

Ongoing
Currently, the bulk of this project is focused on three main pieces: Thermal MagIC: An SI-Traceable Method for 3D Thermal Magnetic Imaging and Control Magnetic Refrigeration Magnetic Standard Reference Materials (SRMs) Thermal MagIC (MAGnetic Imaging and Control) is focused on developing new

Metrology for Nanoimprint Lithography

Completed
Nanoimprint Lithography (NIL) was originally perceived as a versatile, low-cost, and high-resolution patterning alternative for optical lithography in CMOS fabrication. However, it is becoming apparent that NIL has great potential for nanotechnology in general. It is capable of patterning sub-10 nm
CDSAXS instrument

Metrology for Nanolithography

Ongoing
Small Angle Scattering techniques are employed to measure, with sub-nm precision, pattern shape, dimensions, and orientation for structures created in periodic arrays. Critical-Dimension Small Angle X-ray Scattering (CD-SAXS) utilizes the variable-angle transmission scattering from a small beam size
Nanomaterial-containing Drug Classes graphic

Metrology for Nanomaterials in Medicine

Ongoing
Drug products that incorporate nanomaterials are defined by FDA as non-biological complex drugs (NBCDs). NBCDs are a class of medical products that cannot be defined nor fully identified as traditional small-molecule drugs. NBCDs consist of different components that form a complex hybrid structure
Metrology is the foundation of the entire semiconductor enterprise. Standards provide the highest “value added” of all processes.

Metrology of Purity and Contaminants in Solid Materials

Ongoing
Purity evaluations of high-purity bulk materials used in chips manufacturing are calibrated against reference materials that are often not matrix-matched to the materials under test. In other words, differences in the compositions of the calibrants and the samples being analyzed can result in large
Photograph of a dog sniffing luggage.

Metrology and Standards for Canine Olfactory Detection of Explosives

Completed
Effective and accepted by the public, trained dogs are the most frequently deployed detection systems for identification of explosives threats in mobile applications. In addition to being highly sensitive, dogs can rapidly discriminate the unique profile of an explosive in a presence of a large

Microbial Genomic Measurements

Completed
The RM 8375 is a stable and homogeneous material whose intended use is whole genome sequencing quality control and proficiency testing. The genomic DNA is intended to be analyzed in the same way as any other sample a laboratory would analyze extracted DNA, such as through the use of genome assembly
Figure showing four components of metabolomics with samples and processing

Microbial Metabolomics

Ongoing
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy are widely used and complementary analytical platforms for the characterization, identification, and quantification of a metabolome. MS techniques, typically coupled to chromatography, provide a chemical fingerprint of complex

Microcryocooler for Terahertz Detectors

Ongoing
DARPA has been interested in the development of cooled detector systems (infrared and terahertz) that require less than 1 W of input power (battery operated) and have a total volume less than about 4 cm 3. Such systems could be used for detection of enemy missile launches (infrared), chemical
MMQAP figure

Micronutrients Measurement Quality Assurance Program (MMQAP)

Completed
The MMQAP supported the long-term (months to years) reliability of selected fat- or water-soluble vitamin measurements in human serum and plasma. Results from the comparison studies helped participants to make accurate clinical and health-care decisions as well as to maintain and improve their

Microplastic and Nanoplastic Metrology

Ongoing
The Micro and Nanoplastic (MNP) Metrology Project aims to develop a toolbox of methods for size-based separations from complex matrices, chemical characterization protocols, and test materials necessary to enable quantification of micro- and nano-sized plastic particles, a need articulated by our

Micro-rheometry

Completed
One way to develop small-volume rheology methods that we have used successfully is to start with existing concepts and geometries of rheometry and to then "think small." This approach ensures that we are measuring fundamental materials properties rather than quantities that are experiment and

Microscopy Methods

Completed
Due to projection effects, analytical transmission electron microscopy (AEM) of thinned or sectioned samples has traditionally been limited to essentially two-dimensional imaging and analysis. Current nanometer scale devices are too small and complex for current sectioning capabilities and two

Microstructure-Property Tools for Structure-Property Design

Materials Digital Twins for AM Current methodologies for designing digital twins in additive manufacturing (AM) exhibit two main approaches: one involves AI models. that establish a direct correlation between input and output properties, overlooking materials structure and characterization, while
A stainless steel micro tensile specimen in a silicon frame.

Microsystems for Harsh Environment Testing

Completed
Classically, measurement of the mechanical properties and reliability of bulk-scale materials is performed with macroscopic specimens and methods. Specimen preparation limitations, miniaturized load-frame tooling problems, and inadequate understanding of the roles of specimen size and constraint on
MGI-Logo

Modeling Dispersion Rheology for Non-Spherical Particles

Completed
The goal of this MGI project is to establish an interactive database, generated by sophisticated modeling, such as dissipative particle dynamics and smooth particle hydrodynamics, to compute the rheological properties of polymer composites, where interaction among inclusions, inclusion particle

Modeling Photon Absorption in Composite Resin Systems

Ongoing
In this work, we establish a method to calculate the spatial absorption and scattering parameters for composite resins during photopolymerization. The inputs to this model are based on the characteristics of the resin system (e.g., monomer and filler structure and composition, filler size and
Graphic of a erlenmeyer flask containing tilled soil, a green leaf, and yellow wheat.

Molecular Innovation in Agriculture

Ongoing
Plant science and breeding aim to develop new plant phenotypes with desired qualities, increased production, disease resistance, and traits that reduce water usage. At the federal level, plant research is conducted by the USDA's Animal and Plant Health Inspection Service (APHIS) and Agricultural
Chain orientation of polyethylene by polarization BCARS

3D Molecular Orientation Imaging

Ongoing
We have developed 3D orientation measurement techniques by analyzing polarization-dependent molecular vibrational signals based on infrared (IR) absorption [1,2] and coherent anti-Stokes Raman scattering (CARS) [3]. The two imaging modalities are complementary to each other: IR imaging broadly
NIST MS Search 2

Monoclonal Antibody Mass Spectral Libraries

Ongoing
Intended Impact Modern mass spectrometers used in the field of proteomics and glycomics are capable of profiling hundreds, and even thousands of molecules in a single experiment. Each of these compounds is isolated and fragmented to form a mass spectrum. Therefore, interpretation of these mass

Mouse Allelic Ladder

Ongoing
What is an allelic ladder? An allelic ladder is a mixture of highly characterized alleles (known size and sequence) that are generated using the same primers as the test samples and are used during capillary electrophoresis for accurate allele call determination. Why is an allelic ladder important
MPXV RGTM wrapped linear insert

Mpox (MPXV) Synthetic DNA PCR Standards

Ongoing
A new material from NIST can aid in the evaluation and development of selected qPCR assays for the mpox virus. We are offering a unit free of charge in exchange for your feedback, which will help us improve and further develop the material. Questions? Contact MPXV-RGTM [at] nist.gov (MPXV-RGTM[at]nist[dot]gov) . NIST supports the
Two-dimensional chromatogram showing the separation of four compounds as shaded elliptical areas

Multidimensional Chromatography

Ongoing
The development of robust analytical methods remains one of the most important (and costly) parts of chemical metrology. The separation of targeted constituents from other components in a sample matrix is necessary for accurate and precise measurements. Multidimensional chromatography is an
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