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Material Measurement Laboratory

Projects/Programs

Displaying 26 - 50 of 568
Hexagon containing words “environmental metabolomics” with arrows pointing from the hexagon to each of the following images: coral, shrimp, mussel, microbe, horseshoe crab, plant. The circle figure has waves and a tree faded in the background.

Applications in Metabolomics

Ongoing
The application of metabolomics techniques to systems biology reveals insights into model and non-model organism biology. The natural world contains undiscovered chemicals and mechanisms that can be harnessed by industry to create new biomanufacturing processes and products. Each biological system
Gears with the word "manufacturing"

Artificial Intelligence for Chemical Manufacturing

Ongoing
The chemical manufacturing design process relies heavily on the recommended values that engineers and researchers usually obtain from handbooks and databases. Those sources often lack easy ways to judge the reliability of information, either in the sense of where the data come from or what the
nanoparticle model

Assessing the Environmental, Health and Safety Impact of Nanoparticles

Completed
Impact Nanomaterials have already been incorporated into a large range of commercial products including pharmaceuticals, sunscreens, automobile additives, personal care products, detergents and plastics. Although nanotechnology is changing the way we live, the accidental release of nanomaterials

Assessment of Uncertainty in CALPHAD Descriptions

Ongoing
Knowledge of phase equilibria and phase transformations is absolutely essential for the development of new materials and processing methods. The CALPHAD (CALculation of PHAse Diagrams) method is a proven, indispensable tool in this endeavor. It combines thermodynamic descriptions of binary and

Atomistic Potentials and the Future of Nanomaterials Metrology

Ongoing
Atomistic simulations are increasingly being used as a tool to understand and predict properties of materials in systems, such as nanomaterials, where direct measurement is time-consuming or extremely difficult. The success of atomistic simulations depends critically on the fidelity of a specific

Atomistic tools for structure-property investigations

Ongoing
Interatomic Potential Repository The Interatomic Potentials Repository (IPR) provides a source for interatomic potentials (force fields), related files, and evaluation tools to help researchers obtain interatomic models and judge their quality and applicability. The files provided are of known
Photograph of gas cylinders

Audit of EPA Protocol Gas Suppliers

Ongoing
Protocol gas standards are employed in measurements made for compliance purposes; one of the major uses is for measurements of regulated gaseous species from stationary source emitters, i.e., stack gases. Many of these stationary sources are regulated through the Cap and Trade program; therefore

Automation for Atomistic Simulation

Ongoing
In computational materials science, many problems require the execution of numerous parallel simulation tasks on High Performance Computing (HPC) resources. Often a single published data point is the result of several parallel tasks executed in a specific sequence. Despite the continual improvement

Automotive Lightweighting

Ongoing
The US auto industry spends $600M per year fixing and tweaking forming dies that do not make correct parts. The primary reason that the dies are inaccurate is that the computer models of the dies utilize materials models that are inaccurate. Upon surveying our industrial partners, we determined that
schematic of the scanning droplet cell apparatus

Autonomous Scanning Droplet Cell

Ongoing
Corrosion impacts a broad spectrum of application areas including infrastructure, transportation, and the military. The annual price tag for corrosion mitigation and remediation is 3.4 % of the US GDP. The team is particularly interested in discovering new metallic glasses (metals without long range
Schematic image of automated MOF synthesis platform under construction.

Autonomous Synthesis of Metal-Organic Frameworks

Ongoing
Metal-organic frameworks (MOFs) show great promise for a variety of applications, from industrial gas separation, to catalysis, to PFAS absorption. One challenge to the adoption of these technologies is determining and optimizing the synthesis of these materials. There are large computational
infographic explaining how a battery passport works

EV Battery Passport

Completed
End-of-life issues associated with EV batteries (EVBs) are estimated to have a steep rise in the coming decades. Given the finite nature of material resources worldwide, developing a circular EV batteries (EVB) infrastructure is needed to keep high value battery materials in the economy, therefore
Streptococcus mutans

Biofilm Models to Evaluate Structure-Function Relationships

Ongoing
Biofilms are complex 3D microbial structures that exist throughout nature including on our skin and gut mucosa, in waterways, and in soil. They are typically composed of multiple microbial species surrounded by proteins, polysaccharides, and extracellular DNA woven together into a hydrated matrix

Bioimaging

Completed
Imaging and image analysis are used ubiquitously in biological and biomedical research. One of the great advantages of imaging is its intuitive information content; much can be learned from just a glance at the data. On the other hand, these data generally contain a very large amount of untapped
Bioman lifecycle

Biomanufacturing Initiative

Ongoing
The objective of the NIST biomanufacturing program is to support US biopharmaceutical industry delivery of high quality and low cost protein drugs around the world. The mission is fulfilled through the development of standards, measurement science, and state of the art tools that support advances in

Biomaterials for Oral Health

Completed
NIST along with its partners has a long commitment to scientific excellence with demonstrated impact in improving the oral health of the public. NIST researchers are leaders in this field and create a community by engaging other researchers, industry, and regulatory agencies to address urgent needs

Bioprocess Modeling for Expansion of Cell Culture

Ongoing
One of the most critical steps in bioprocessing is the controlled expansion of frozen cell cultures to generate sufficient cell quantities for manufacturing cell-based products or assay systems. This project focuses on building a scalable model for cell expansion processes that can support the

Bioprocessing Laboratory

Ongoing
Current Capabilities Computer controlled liquid nitrogen biostorage system Two culture areas including 4 monitored CO2 incubators 2 Six-foot BSLII biosafety cabinets Measurements- cell count and concentration, STR typing, flow cytometry, cell volume size distribution, conventional transmission and
Genetic codes

Biosecurity for Synthetic Nucleic Acid Sequences

Ongoing
Synthetic nucleic acid technologies are fundamental to U.S. biotechnology and biomanufacturing innovation. However, like other transformative technologies, they carry dual-use potential: while they can drive significant progress, they pose risks of unintentional or deliberate misuse to engineer
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