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Office of the Director

Projects/Programs

Displaying 876 - 900 of 1598
Nanomaterial-containing Drug Classes graphic

Metrology for Nanomaterials in Medicine

Ongoing
Drug products that incorporate nanomaterials are defined by FDA as non-biological complex drugs (NBCDs). NBCDs are a class of medical products that cannot be defined nor fully identified as traditional small-molecule drugs. NBCDs consist of different components that form a complex hybrid structure
QHARS

Metrology of the Ohm

Ongoing
The Metrology of the Ohm Project has been a leader in providing internationally consistent resistance standards that are readily available to support the scientific and industrial foundations of the U.S. economy. Through this very broad customer base, the activities of the project enable cost

Metrology for Printing and Graphic Arts Substrates

Ongoing
Paper is a complex, heterogeneous, multi-phased material. While there is a significant body of work related to the dielectric properties of cellulose, comparatively fewer studies have been done on printing and writing grades of paper. In our previous work, we have been able to differentiate between
Metrology is the foundation of the entire semiconductor enterprise. Standards provide the highest “value added” of all processes.

Metrology of Purity and Contaminants in Solid Materials

Ongoing
Purity evaluations of high-purity bulk materials used in chips manufacturing are calibrated against reference materials that are often not matrix-matched to the materials under test. In other words, differences in the compositions of the calibrants and the samples being analyzed can result in large

Metrology for Real-Time Monitoring of Additive Manufacturing

Completed
Objective To develop and disseminate metrology methods, tools, data, and standards applied to in-situ monitoring of AM processes, such that manufacturers and their customers can accurately and precisely determine the quality of the fabrication process and resulting parts. What is the Technical Idea

metRology Software Project

Ongoing
DESCRIPTION: The current version of the metRology package focuses on statistical functions for uncertainty analysis and for the analysis of interlaboratory studies and key comparisons. A number of the functions focus on uncertainty analysis using the methods outlined in the JCGM Guide to the
Photograph of a dog sniffing luggage.

Metrology and Standards for Canine Olfactory Detection of Explosives

Completed
Effective and accepted by the public, trained dogs are the most frequently deployed detection systems for identification of explosives threats in mobile applications. In addition to being highly sensitive, dogs can rapidly discriminate the unique profile of an explosive in a presence of a large
A micromechanical bulk acoustic resonator that uses phononic crystal tethers to achieve a quality factor approaching the fundamental dissipation limit (fxQ can be as large as 1.2 x 1013 Hz)

Micro- and Nanoelectromechanical Systems

Completed
MEMS/NEMS are enabling technologies that bring new functionalities with the potential to radically transform markets ranging from consumer products to national defense. The meteoric rise of the smartphone is an excellent example, in which MEMS accelerometers, gyroscopes, microphones, displays, and

Micro- and nano-optomechanical systems

Ongoing
Our primary current research direction involves the use of fabricated devices with sub-wavelength periodicity (photonic crystals) as optomechanical elements. Such structures enable a rich variety of devices, including mirrors, polarizers, and filters, in a configuration that couples naturally to

Microbial Genomic Measurements

Completed
The RM 8375 is a stable and homogeneous material whose intended use is whole genome sequencing quality control and proficiency testing. The genomic DNA is intended to be analyzed in the same way as any other sample a laboratory would analyze extracted DNA, such as through the use of genome assembly
Figure showing four components of metabolomics with samples and processing

Microbial Metabolomics

Ongoing
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy are widely used and complementary analytical platforms for the characterization, identification, and quantification of a metabolome. MS techniques, typically coupled to chromatography, provide a chemical fingerprint of complex
scanning electron microscope

Microcalorimeter Spectrometers for X-ray and Gamma-ray Spectroscopy

Ongoing
The Quantum Calorimeters Project in the Quantum Sensors Group develops and applies sensors that detect the energy of single photons or particles. For example, Transition-Edge Sensors (TESs) are able to measure the energy of single x-ray and gamma-ray photons with a precision better than one part per

Microcryocooler for Terahertz Detectors

Ongoing
DARPA has been interested in the development of cooled detector systems (infrared and terahertz) that require less than 1 W of input power (battery operated) and have a total volume less than about 4 cm 3. Such systems could be used for detection of enemy missile launches (infrared), chemical
Fiber magnetometer

Microfabricated Atomic Sensors

Ongoing
Our program aims to develop sensors that can simultaneously achieve high absolute scalar accuracy and vector magnetic field measurement without the need for calibrations. An atomic magnetometer relies on the fundamental constants of nature to translate magnetic fields into a measurable Larmor

Microfluidic Synthesis of Nanoparticles

Ongoing
Liposomes have found many applications, including targeted drug delivery, immunoassay amplification, and medical imaging. For targeted drug delivery and medical imaging applications, the microfluidic-synthesis method could allow the synthesis of liposomes at the point of care, so that problems with
MMQAP figure

Micronutrients Measurement Quality Assurance Program (MMQAP)

Completed
The MMQAP supported the long-term (months to years) reliability of selected fat- or water-soluble vitamin measurements in human serum and plasma. Results from the comparison studies helped participants to make accurate clinical and health-care decisions as well as to maintain and improve their

Microplastic and Nanoplastic Metrology

Ongoing
The Micro and Nanoplastic (MNP) Metrology Project aims to develop a toolbox of methods for size-based separations from complex matrices, chemical characterization protocols, and test materials necessary to enable quantification of micro- and nano-sized plastic particles, a need articulated by our
Microcombs2

Microresonator Device Research

Ongoing
In the last few years a revolutionary paradigm for optical frequency combs and ultrastable continuous-wave lasers has emerged based on nonlinear optics in optical microresonators. Such microresonator devices can now be realized using millimeter-scale, chip-based photonic integrated circuits
microcombs

Microresonator frequency combs for the NIST-on-a-Chip Program

Ongoing
The invention of optical-frequency combs opened many new applications in photonics from precision timing and ranging to generation of entangled states. They are composed of hundreds to millions of optical modes whose frequencies conform to a simple relationship, ν n = n × f rep +f 0, where n is the

Micro-rheometry

Completed
One way to develop small-volume rheology methods that we have used successfully is to start with existing concepts and geometries of rheometry and to then "think small." This approach ensures that we are measuring fundamental materials properties rather than quantities that are experiment and

Microscopy Methods

Completed
Due to projection effects, analytical transmission electron microscopy (AEM) of thinned or sectioned samples has traditionally been limited to essentially two-dimensional imaging and analysis. Current nanometer scale devices are too small and complex for current sectioning capabilities and two

Microstructure-Property Tools for Structure-Property Design

Ongoing
Materials Digital Twins for AM Current methodologies for designing digital twins in additive manufacturing (AM) exhibit two main approaches: one involves AI models. that establish a direct correlation between input and output properties, overlooking materials structure and characterization, while
A stainless steel micro tensile specimen in a silicon frame.

Microsystems for Harsh Environment Testing

Completed
Classically, measurement of the mechanical properties and reliability of bulk-scale materials is performed with macroscopic specimens and methods. Specimen preparation limitations, miniaturized load-frame tooling problems, and inadequate understanding of the roles of specimen size and constraint on
NIST Calibration Target

Miniaturized Microwave Absolute Calibration

Ongoing
The small-satellite development has seen significant growth in recent years. Due to the size limitation, the conventional calibration device can no longer be equipped on the small-satellite platform. Consequently, new technology is called for to provide a precise and traceable calibration solution
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